156-86-5
Chemical Structure
H-HoArg-OH
Synonym(s): L-Homoarginine
- CAS No.: 156-86-5
- Formula:C7H16N4O2
- Molecular Weight:188.23
IUPAC Name: N6-carbamimidoyl-L-lysine
InChIKey: QUOGESRFPZDMMT-YFKPBYRVSA-N
SMILES: [H][C@](N)(CCCCNC(N)=N)C(O)=O
Biological Activity: H-HomoArg-OH (L-Homoarginine) is an orally active endogenous non-protein amino acid. H-HomoArg-OH acts as a weak alternative substrate for NOS and interferes with NO production, selectively inhibits tissue-nonspecific alkaline phosphatase (TNAP), and suppresses the uptake of arginine by y+-type transporters (system y+). H-HomoArg-OH increases tissue hArg concentrations in vivo, regulates amino acid homeostasis, and improves renal function and pathological features of diabetic nephropathy. H-HomoArg-OH can be used in studies related to diabetes and cardiomyopathy[1][2][3][4][5].
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H-HoArg-OH | 98.0% | H-HomoArg-OH (L-Homoarginine) is an orally active endogenous non-protein amino acid. H-HomoArg-OH acts as a weak alternative substrate for NOS and interferes with NO production, selectively inhibits tissue-nonspecific alkaline phosphatase (TNAP), and suppresses the uptake of arginine by y+-type transporters (system y+). H-HomoArg-OH increases tissue hArg concentrations in vivo, regulates amino acid homeostasis, and improves renal function and pathological features of diabetic nephropathy. H-HomoArg-OH can be used in studies related to diabetes and cardiomyopathy. | ||||||||||||||||||||
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H-HoArg-OH (Standard) | 98.71% | H-HoArg-OH (Standard) (L-Homoarginine (Standard)) is the analytical standard of H-HoArg-OH (HY-W008385). This product is intended for research and analytical applications. H-HomoArg-OH (L-Homoarginine) is an orally active endogenous non-protein amino acid. H-HomoArg-OH acts as a weak alternative substrate for NOS and interferes with NO production, selectively inhibits tissue-nonspecific alkaline phosphatase (TNAP), and suppresses the uptake of arginine by y+-type transporters (system y+). H-HomoArg-OH increases tissue hArg concentrations in vivo, regulates amino acid homeostasis, and improves renal function and pathological features of diabetic nephropathy. H-HomoArg-OH can be used in studies related to diabetes and cardiomyopathy. | ||||||||||||||||||||
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Similarity Score 0.97
HY-W012340H-HomoArg-OH hydrochloride -
Similarity Score 0.97
HY-W012340SH-HomoArg-OH-13C7,15N4 hydrochloride -
Similarity Score 0.96
HY-N0454DL-Arginine -
Similarity Score 0.96
HY-N0455L-Arginine -
Similarity Score 0.96
HY-W016781D-Arginine -
Similarity Score 0.94
HY-N0455AS1L-Arginine-15N4 hydrochloride -
Similarity Score 0.94
HY-N0455AS3L-Arginine-1-13C hydrochloride -
Similarity Score 0.94
HY-N0455AS5L-Arginine-1,2-13C2 hydrochloride -
Similarity Score 0.94
HY-N0455AS6L-Arginine-13C6 hydrochloride -
Explore the MedChemAI to find more analogs
References
- [1]. Hira T, et al. L-homoarginine suppresses exocrine pancreas in rats. Amino acids. 2003 Jun;24(4):389-96.
- [2]. Wetzel MD, et al. l-Homoarginine supplementation prevents diabetic kidney damage. Physiological reports. 2019 Sep;7(18):e14235.
- [3]. Hou Y, et al. Whole-body synthesis of L-homoarginine in pigs and rats supplemented with L-arginine. Amino acids. 2016 Apr;48(4):993-1001.
- [4]. Fishman W, et al. L-homoarginine; an inhibitor of serum "bone and liver" alkaline phosphatase. Clin Chim Acta. 1970 Aug;29(2):339-41. [Content Brief]
- [5]. Tsikas D, et al. Pilot Study on Acute Effects of Pharmacological Intraperitoneal L-Homoarginine on Homeostasis of Lysine and Other Amino Acids in a Rat Model of Isoprenaline-Induced Takotsubo Cardiomyopathy. International journal of molecular sciences. 2022 Apr 25;23(9):4734.
