H-HoArg-OH-d4 dihydrochloride
H-HoArg-OH-d4 dihydrochloride (L-Homoarginine-d4 dihydrochloride) is the d4-labeled H-HoArg-OH dihydrochloride. H-HoArg-OH dihydrochloride (L-Homoarginine dihydrochloride) is an orally active endogenous non-protein amino acid. H-HoArg-OH dihydrochloride acts as a weak alternative substrate for NOS and interferes with NO production, selectively inhibits tissue-nonspecific alkaline phosphatase (TNAP), and suppresses the uptake of arginine by y+-type transporters (system y+). H-HoArg-OH dihydrochloride increases tissue hArg concentrations in vivo, regulates amino acid homeostasis, and improves renal function and pathological features of diabetic nephropathy. H-HoArg-OH dihydrochloride can be used in studies related to diabetes and cardiomyopathy.
For research use only. We do not sell to patients.
- Purity : 97.22%
- Formula: C7H14D4Cl2N4O2
- Molecular Weight:265.17
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
All Endogenous Metabolite Isoforms
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Biological Activity
Description
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Appearance Liquid
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Molecular Weight 265.17
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Formula C7H14D4Cl2N4O2
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Color Colorless to light yellow
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SMILES
OC([C@@H](N)CC([2H])([2H])C([2H])([2H])CNC(N)=N)=O.Cl.Cl
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Synonyms
L-Homoarginine-d4 dihydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Keywords
- H-HoArg-OH-d4
- L-Homoarginine-d4
- Isotope-Labeled Compounds
- Endogenous Metabolite
- Monocarboxylate Transporter
- Phosphatase
- AGAT
- diabetic nephropathy
- CCK receptor
- pancreatic beta cells
- serum alkaline phosphatase
- Sprague-Dawley rats
- lysine transporter
- takotsubo cardiomyopathy
- Ins2Akita mice
- nitric oxide synthase
- Inhibitor
- inhibitor
- inhibit