ALP/Carbonic anhydrase-IN-1
Based on 1 Customer Validation
ALP/Carbonic anhydrase-IN-1 (Compound 1e) is a dual carbonic anhydrase (CA) and alkaline phosphatase (ALP) inhibitor. ALP/Carbonic anhydrase-IN-1 shows IC50 values of 0.44 µM, 1.61 µM, 0.51 µM, and 0.107 µM for CA-II, CA-IX, CA-XII, and ALP, respectively.
For research use only. We do not sell to patients.
- Purity : 99.90%
- CAS No.: 2091887-74-8
- Formula: C15H16N2
- Molecular Weight:224.30
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
CA Ⅱ 0.44 μM (IC50) |
CA IX 1.61 μM (IC50) |
CA XII 0.51 μM (IC50) |
Alkaline phosphatase 0.107 μM (IC50) |
Chemical Information
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CAS No. 2091887-74-8
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Appearance Solid
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Molecular Weight 224.30
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Formula C15H16N2
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Color Off-white to light yellow
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SMILES
CCCCC1=CC2=C(N=CC=C2)N3C=CC=C13
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (445.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 4.4583 mL | 22.2916 mL | 44.5831 mL | 111.4579 mL |
| 5 mM | 0.8917 mL | 4.4583 mL | 8.9166 mL | 22.2916 mL | |
| 10 mM | 0.4458 mL | 2.2292 mL | 4.4583 mL | 11.1458 mL | |
| 15 mM | 0.2972 mL | 1.4861 mL | 2.9722 mL | 7.4305 mL | |
| 20 mM | 0.2229 mL | 1.1146 mL | 2.2292 mL | 5.5729 mL | |
| 25 mM | 0.1783 mL | 0.8917 mL | 1.7833 mL | 4.4583 mL | |
| 30 mM | 0.1486 mL | 0.7431 mL | 1.4861 mL | 3.7153 mL | |
| 40 mM | 0.1115 mL | 0.5573 mL | 1.1146 mL | 2.7864 mL | |
| 50 mM | 0.0892 mL | 0.4458 mL | 0.8917 mL | 2.2292 mL | |
| 60 mM | 0.0743 mL | 0.3715 mL | 0.7431 mL | 1.8576 mL | |
| 80 mM | 0.0557 mL | 0.2786 mL | 0.5573 mL | 1.3932 mL | |
| 100 mM | 0.0446 mL | 0.2229 mL | 0.4458 mL | 1.1146 mL |
ALP/Carbonic anhydrase-IN-1 Related Classifications
HY-157139 Related Classifications
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