ALP/Carbonic anhydrase-IN-1

Name: ALP/Carbonic anhydrase-IN-1
Brand: MedChemExpress
SKU: HY-157139
Rating: 4.5 (1 reviews)

製品番号: HY-157139 純度: 99.90%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

ALP/Carbonic anhydrase-IN-1 (Compound 1e) is a dual carbonic anhydrase (CA) and alkaline phosphatase (ALP) inhibitor. ALP/Carbonic anhydrase-IN-1 shows IC₅₀ values of 0.44 µM, 1.61 µM, 0.51 µM, and 0.107 µM for CA-II, CA-IX, CA-XII, and ALP, respectively.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

ALP/Carbonic anhydrase-IN-1 構造式

CAS 番号 : 2091887-74-8

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 242	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 242	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$220	在庫あり	Estimated Time of Arrival: December 31
10 mg	$350	在庫あり	Estimated Time of Arrival: December 31
25 mg	$685	在庫あり	Estimated Time of Arrival: December 31
50 mg	$1100	在庫あり	Estimated Time of Arrival: December 31
100 mg	$1650	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Carbonic Anhydrase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

CA CA I CA Ⅱ CA IX CA XII CA VII CA VI CA VA CA VB CA XIII CA XIV

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target^[1]

CA Ⅱ

0.44 μM (IC₅₀)

CA IX

1.61 μM (IC₅₀)

CA XII

0.51 μM (IC₅₀)

Alkaline phosphatase

0.107 μM (IC₅₀)

分子量

224.30

分子式

C₁₅H₁₆N₂

CAS 番号

2091887-74-8

Appearance

Solid

Color

Off-white to light yellow

SMILES

CCCCC1=CC2=C(N=CC=C2)N3C=CC=C13

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (445.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.4583 mL	22.2916 mL	44.5831 mL
5 mM	0.8917 mL	4.4583 mL	8.9166 mL
10 mM	0.4458 mL	2.2292 mL	4.4583 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (11.15 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.90%

Select Batch:

データシート (272 KB) SDS (251 KB)

COA (248 KB) HNMR (247 KB) LCMS (102 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Salman Alrokayan, et al. [1, 8]-Naphthyridine derivatives as dual inhibitor of alkaline phosphatase and carbonic anhydrase. BMC Chem. 2023 Oct 25;17(1):142. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.4583 mL	22.2916 mL	44.5831 mL	111.4579 mL
	5 mM	0.8917 mL	4.4583 mL	8.9166 mL	22.2916 mL
	10 mM	0.4458 mL	2.2292 mL	4.4583 mL	11.1458 mL
	15 mM	0.2972 mL	1.4861 mL	2.9722 mL	7.4305 mL
	20 mM	0.2229 mL	1.1146 mL	2.2292 mL	5.5729 mL
	25 mM	0.1783 mL	0.8917 mL	1.7833 mL	4.4583 mL
	30 mM	0.1486 mL	0.7431 mL	1.4861 mL	3.7153 mL
	40 mM	0.1115 mL	0.5573 mL	1.1146 mL	2.7864 mL
	50 mM	0.0892 mL	0.4458 mL	0.8917 mL	2.2292 mL
	60 mM	0.0743 mL	0.3715 mL	0.7431 mL	1.8576 mL
	80 mM	0.0557 mL	0.2786 mL	0.5573 mL	1.3932 mL
	100 mM	0.0446 mL	0.2229 mL	0.4458 mL	1.1146 mL