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Cholinesterase+Inhibitors

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By Targets:	Apoptosis (1) Beta-secretase (1) Calcium Channel (2) Cholinesterase (ChE) (28) Drug Intermediate (1) Drug Metabolite (2) Histamine Receptor (1) Isotope-Labeled Compounds (3) mAChR (1) Potassium Channel (4) Reactive Oxygen Species (ROS) (2) Reference Standards (5) Sodium Channel (4) Topoisomerase (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (2) Endocrinology (1) Infection (2) Inflammation/Immunology (5) Metabolic Disease (7) Neurological Disease (22)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-134124

Glutathione ethyl ester	Reactive Oxygen Species (ROS)	Metabolic Disease
Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense .

HY-B0423

Neostigmine Bromide 1 Publications Verification Eustigmin bromide; Neoserine bromide	Cholinesterase (ChE)	Neurological Disease
Neostigmine (Eustigmin) Bromide is an orally active and reversible cholinesterase inhibitor that acts on myasthenia gravis to prolong and intensify the muscarinic and nicotinic effects of acetylcholine. Neostigmine Bromide can be used in anesthesia to reverse the neuromuscular blockade produced by competitive neuromuscular blockers .

HY-W027553

Ipidacrine NIK-247 free base; Amiridine free base	Cholinesterase (ChE) Potassium Channel Sodium Channel	Neurological Disease Metabolic Disease
Ipidacrine is orally active and brain-penetrant AChE and BuChE inhibitors with IC₅₀ values of 1 μM and 1.9 μM, respectively, which is also a partial agonist of M2-cholinergic receptors and a reversible *cholinesterase* inhibitor. Ipidacrine has a stimulating effect on neuromuscular transmission and excitation along the nerve fibres with a moderately anti-pain effect. Ipidacrine is an aminopyridines and is structurally similar to Tacrine (HY-111338). Ipidacrine is effective in various amnesia models, improves erectile function and inhibits K ⁺ and Na ⁺-channels in the neuronal membrane in diabetic rats. Ipidacrine is promising for research of Alzheimer’s disease, ischaemic stroke, idiopathic neuropathy of the facial nerve, diabetes mellitus-induced erectile dysfunction and other deficits in central or peripheral cholinergic deseases .

HY-B1626A

Demecarium Bromide BC-48	Cholinesterase (ChE)	Neurological Disease
Demecarium Bromide (BC-48) is a potent *cholinesterase* inhibitor, with an apparent affinity (K_iapp) of 0.15 μM . Demecarium Bromide (BC-48) is used as a glaucoma agent .

HY-B0207AS

Pyridostigmine-d6 bromide	Cholinesterase (ChE)	Others
Pyridostigmine-d₆ (bromide) is the deuterium labeled Pyridostigmine, which is a parasympathomimetic and a reversible cholinesterase inhibitor.

HY-W022759

9-Acridinecarboxylic acid	Cholinesterase (ChE)	Others
9-Acridinecarboxylic acid is a precursor of a *cholinesterase* inhibitor, and its derivatives have nanomolar inhibitory potency against AChE and BChE .

HY-N6865

Groenlandicine 2 Publications Verification	Cholinesterase (ChE) Topoisomerase Reactive Oxygen Species (ROS) Beta-secretase Apoptosis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Groenlandicine, a protoberberine alkaloid, is a *cholinesterase* inhibitor (AChE (IC₅₀ = 0.54 μM), BChE (IC₅₀ = 3.32 μM)). Groenlandicine non-competitively inhibits BACE1 (IC₅₀ = 19.68 μM, K_i = 21.2) and inhibits RLAR (IC₅₀ = 140.1 μM), HRAR (IC₅₀ = 154.2 μM), and total ROS generation (IC₅₀ = 51.78 μM) in vitro. Groenlandicine suppresses osteosarcoma cell proliferation while promoting apoptosis. Groenlandicine inhibits the tumor growth when combined with Cisplatin (HY-17394). Groenlandicine can be used for the study on osteosarcoma, Alzheimer's disease and diabetes mellitus .

HY-W011246

Velnacrine maleate HP 029; Hydroxytacrine maleate	Cholinesterase (ChE)	Neurological Disease
Velnacrine maleate (HP 029) is an orally active *cholinesterase* inhibitor that can be used for the research of Alzheimer's disease .

HY-N12581

Kuwanon U	Cholinesterase (ChE)	Neurological Disease
Kuwanon U is a potent *cholinesterase* inhibitor with IC₅₀s of 19.69, 10.11 µM and K_is of 6.48, 9.59 µM for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), respectively. Kuwanon U has the potential for the research of Alzheimer’s disease (AD) .

HY-N15710

Magnotriol B	Cholinesterase (ChE)	Neurological Disease Inflammation/Immunology
Magnotriol B is a *cholinesterase inhibitor* with IC₅₀ values of 12.63 nM and 14.5 nM against AChE and BChE, respectively. Magnotriol B also exhibits significant NO inhibitory activity with an IC₅₀ of 2.02 μM. Magnotriol B can be used in the research of neurodegenerative and inflammatory diseases .

HY-P2424

Cholecystokinin-J CCK-J	Calcium Channel	Others
Cholecystokinin-J (CCK-J), a cholecystokinin, stimulates Ca ²⁺ release .

HY-W272207

AChE/BChE-IN-31	Cholinesterase (ChE) Drug Intermediate	Neurological Disease Inflammation/Immunology
AChE/BChE-IN-31 (Compound 3c) is a *cholinesterase* inhibitor. AChE/BChE-IN-31 exhibits certain inhibitory activity against hAChE and eqBChE. AChE/BChE-IN-31 also possesses antioxidant properties with an IC₅₀ value of 105.04 μM against DPPH. AChE/BChE-IN-31 can be used in the research of diseases such as Alzheimer’s disease .

HY-W027553R

Ipidacrine (Standard) NIK-247 free base (Standard); Amiridine free base (Standard)	Reference Standards Cholinesterase (ChE) Potassium Channel Sodium Channel	Neurological Disease Metabolic Disease
Ipidacrine (Standard) is the analytical reference standard of Ipidacrine. This product is used for research and analytical applications. Ipidacrine is orally active and blood-brain-barrier-penetrant AChE and BuChE inhibitors with IC₅₀ values of 1 μM and 1.9 μM, respectively, which is also a partial agonist of M2-cholinergic receptors and a reversible *cholinesterase* inhibitor. Ipidacrine has a stimulating effect on neuromuscular transmission and excitation along the nerve fibres with a moderately anti-pain effect. Ipidacrine is an aminopyridines and is structurally similar to Tacrine (HY-111338). Ipidacrine is effective in various amnesia models, improves erectile function and inhibits K ⁺ and Na ⁺-channels in the neuronal membrane in diabetic rats. Ipidacrine is promising for research of Alzheimer’s disease, ischaemic stroke, idiopathic neuropathy of the facial nerve, diabetes mellitus-induced erectile dysfunction and other deficits in central or peripheral cholinergic deseases .

HY-119792A

Neostigmine hydroxide	Cholinesterase (ChE)	Metabolic Disease
Neostigmine hydroxide is a *cholinesterase* inhibitor and can be used for study of myasthenia gravis .

HY-11017AS

(S)-Rivastigmine-d6 tartrate	Cholinesterase (ChE)	Others
(S)-Rivastigmine-d₆ (tartrate) is the deuterium labeled (S)-Rivastigmine, which is an cholinesterase inhibitor.

HY-B0207AS1

Pyridostigmine-d3 bromide	Isotope-Labeled Compounds Cholinesterase (ChE)	Neurological Disease
Pyridostigmine-d₃ (bromide) is the deuterium labeled Pyridostigmine bromide. Pyridostigmine bromide is a parasympathomimetic and a reversible cholinesterase inhibitor.

HY-121745

Phosmet oxon Imidoxon; Oxoimidan	Drug Metabolite	Infection
Phosmet oxon (Imidoxon) is a main and toxic metabolite of phosmet. Phosmet is a cholinesterase inhibitor insecticide used on pome and stone fruits .

HY-B0207AR

Pyridostigmine bromide (Standard)	Cholinesterase (ChE) Reference Standards	Neurological Disease
Pyridostigmine (bromide) (Standard) is the analytical standard of Pyridostigmine (bromide). This product is intended for research and analytical applications. Pyridostigmine bromide is a reversible cholinesterase inhibitor.

HY-B0423R

Neostigmine Bromide (Standard) Eustigmin bromide (Standard); Neoserine bromide (Standard)	Reference Standards Cholinesterase (ChE)	Metabolic Disease Cancer
Neostigmine (Bromide) (Standard) is the analytical standard of Neostigmine (Bromide). This product is intended for research and analytical applications. Neostigmine Bromide is a cholinesterase inhibitor that acts on myasthenia gravis.

HY-121745R

Phosmet oxon (Standard) Imidoxon (Standard); Oxoimidan (Standard)	Reference Standards Drug Metabolite	Infection
Phosmet oxon (Standard) is the analytical standard of Phosmet oxon. This product is intended for research and analytical applications. Phosmet oxon (Imidoxon) is a main and toxic metabolite of phosmet. Phosmet is a cholinesterase inhibitor insecticide used on pome and stone fruits .

HY-124047

RX 67668	Cholinesterase (ChE)	Neurological Disease
RX 67668 is a potent *cholinesterase* inhibitor with an IC₅₀ of 5 μM for both acetylcholinesterase (AChE) and butyrylcholinesterase. RX 67668 can reverse the neuromuscular blockade induced by D-tubocurarine. RX 67668 is a muscle relaxant used to relieve skeletal muscle fatigue .

HY-B1626AR

Demecarium Bromide (Standard) BC-48 (Standard)	Reference Standards Cholinesterase (ChE)	Neurological Disease
Demecarium Bromide (Standard) is the analytical standard of Demecarium Bromide. This product is intended for research and analytical applications. Demecarium Bromide (BC-48) is a potent cholinesterase inhibitor, with an apparent affinity (Kiapp) of 0.15 μM . Demecarium Bromide (BC-48) is used as a glaucoma agent .

HY-146035

AChE-IN-14	Cholinesterase (ChE) Histamine Receptor	Neurological Disease
AChE-IN-14 (compound 5) is a potent cholinesterase inhibitor with IC₅₀s of 0.46 , 0.48, and 0.44 μM for electric eel acetylcholinesterase (eeAChE), human recombinant acetylcholinesterase (hAChE), and equine serum butyrylcholinesterase (eqBuChE), respectively. AChE-IN-14 exhibits high affinity toward human H₃ receptor (H₃R; K_i= 159.8 nM). AChE-IN-14 can be used for the research of Alzheimer’s disease .

HY-16183A

Echothiopate chloride Echothiophate chloride	Cholinesterase (ChE)	Cardiovascular Disease
Echothiophate (Echothiophate) chloride is a highly effective, long-lasting cholinesterase inhibitor employed as a miotic for managing glaucoma. Echothiopate chloride forms a covalent bond with the serine residue at the active site of cholinesterase through its phosphate group, rendering the enzyme permanently inactive and necessitating the synthesis of new enzymes by the cell. Given its irreversible binding to cholinesterase and the extremely slow rate of hydrolysis, the effects of echothiophate can persist for a week or longer. Echothiopate chloride is utilized as an ocular antihypertensive agent in the treatment of chronic glaucoma and, in certain cases, accommodative esotropia.

HY-W027553S1

Ipidacrine-d9 NIK-247-d9 free base	Isotope-Labeled Compounds Cholinesterase (ChE) Potassium Channel Sodium Channel	Metabolic Disease
Ipidacrine-d₉ (NIK-247-d₉ (free base)) is the deuterium labeled Ipidacrine (HY-W027553). Ipidacrine is orally active and brain-penetrant AChE and BuChE inhibitors with IC₅₀ values of 1 μM and 1.9 μM, respectively, which is also a partial agonist of M2-cholinergic receptors and a reversible cholinesterase inhibitor. Ipidacrine has a stimulating effect on neuromuscular transmission and excitation along the nerve fibres with a moderately anti-pain effect. Ipidacrine is an aminopyridines and is structurally similar to Tacrine (HY-111338). Ipidacrine is effective in various amnesia models, improves erectile function and inhibits K+ and Na+-channels in the neuronal membrane in diabetic rats. Ipidacrine is promising for research of Alzheimer’s disease, ischaemic stroke, idiopathic neuropathy of the facial nerve, diabetes mellitus-induced erectile dysfunction and other deficits in central or peripheral cholinergic deseases .

HY-179121

AChE-IN-97	Cholinesterase (ChE)	Neurological Disease
AChE-IN-97 (compound 7e) is a *cholinesterase* inhibitor. AChE-IN-97 exhibits AChE and BChE inhibitory activity through molecular docking. AChE-IN-97 can be used for research on neurological conditions .

HY-W011246S

Velnacrine-d3-1 maleate HP 029-d3-1; Hydroxytacrine-d3-1 maleate	Isotope-Labeled Compounds Cholinesterase (ChE)	Neurological Disease
Velnacrine-d₃-1 maleate (HP 029-d₃-1) is the deuterium labeled Velnacrine maleate (HY-W011246). Velnacrine maleate (HP 029) is an orally active cholinesterase inhibitor that can be used for the research of Alzheimer's disease .

HY-173152

AChE/BChE-IN-26	Cholinesterase (ChE)	Neurological Disease Inflammation/Immunology
AChE/BChE-IN-26 (Compound 20aa) is a *cholinesterase* inhibitor with IC₅₀ values of 0.75 μM and 4.11 μM against eeAChE and eqBChE, respectively. AChE/BChE-IN-26 has antioxidant activity and can be used in the research of diseases such as Alzheimer's disease .

HY-172219

CUR-IPA	Cholinesterase (ChE)	Neurological Disease Inflammation/Immunology
CUR-IPA is a *cholinesterase* inhibitor, with IC₅₀ of 5.99, 59.30, and 60.66 μM for eAChE (electric eel), hAChE (human), and hBChE (human), respectively. CUR-IPA can scavenge free radicals and has antioxidant activity. CUR-IPA can be used in the research of cognitive dysfunction .

HY-W754293

Deanol pidolate V0191; DMAE pidolate; DMAE PCA	mAChR	Neurological Disease
Deanol pidolate (V0191; DMAE pidolate) is an orally active pro-cholinergic agent that improves cognitive symptoms by increasing the release of acetylcholine (Ach) and avoids the typical side effects of cholinesterase inhibitors. Deanol pidolate can alleviate the harmful effects of scopolamine on long-term memory and restore to baseline levels more quickly. Deanol pidolate can be used in research on Alzheimer's disease .

HY-181851

AChE-IN-109	Cholinesterase (ChE)	Neurological Disease
AChE-IN-109 is a potent mixed-type cholinesterase inhibitor with significantly stronger inhibitory activity against AChE than BChE. AChE-IN-109 has IC₅₀ values of 0.55 μM and 12.45 μM against AChE and BChE, respectively. AChE-IN-109 inhibits cholinesterases through a mixed-type mechanism, binds to both the catalytic active site (CAS) and peripheral anionic site (PAS) of AChE. AChE-IN-109 can be used for the study of Alzheimer’s disease (AD) .

HY-180892

Multi-kinase-IN-10	Calcium Channel Cholinesterase (ChE)	Neurological Disease
Multi-kinase-IN-10 (Compound IIIk) is a multi-kinase inhibitor. Multi-kinase-IN-10 exhibits significant calcium channel blocking activity, with its IC₅₀ being 26.67 μM. Multi-kinase-IN-10 is a potent dual cholinesterase inhibitor, with its IC₅₀ values for hAChE and hBuChE being 0.304 μM and 1.033 μM respectively. Multi-kinase-IN-10 has antioxidant and neuroprotective activities, and shows significant anti-amnesia activity. Multi-kinase-IN-10 can be used for research on Alzheimer's disease .

HY-19689

Ipidacrine hydrochloride NIK-247; Amiridine	Cholinesterase (ChE) Potassium Channel Sodium Channel	Cardiovascular Disease Neurological Disease Endocrinology
Ipidacrine (NIK-247; Amiridine) hydrochloride is orally active and blood-brain-barrier-penetrant AChE and BuChE inhibitors with IC₅₀ values of 1 μM and 1.9 μM, respectively, which is also a partial agonist of M2-cholinergic receptors and a reversible *cholinesterase* inhibitor. Ipidacrine hydrochloride has a stimulating effect on neuromuscular transmission and excitation along the nerve fibres with a moderately anti-pain effect. Ipidacrine hydrochloride is an aminopyridines and is structurally similar to Tacrine (HY-111338). Ipidacrine hydrochloride is effective in various amnesia models, improves erectile function and inhibits K ⁺ and Na ⁺-channels in the neuronal membrane in diabetic rats. Ipidacrine hydrochloride is promising for research of Alzheimer’s disease, ischaemic stroke, idiopathic neuropathy of the facial nerve, diabetes mellitus-induced erectile dysfunction and other deficits in central or peripheral cholinergic deseases .

Glutathione ethyl ester	Reactive Oxygen Species (ROS)	Metabolic Disease
Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense .

Cholecystokinin-J CCK-J	Calcium Channel	Others
Cholecystokinin-J (CCK-J), a cholecystokinin, stimulates Ca ²⁺ release .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6865

Groenlandicine 2 Publications Verification	Structural Classification Classification of Application Fields Ranunculaceae Metabolic Disease Plants Alkaloids Piperidine Alkaloids Monophenols Coptis chinensis Franch. Phenols Isoquinoline Alkaloids Disease Research Fields Source Classification	Cholinesterase (ChE) Topoisomerase Reactive Oxygen Species (ROS) Beta-secretase Apoptosis
Groenlandicine, a protoberberine alkaloid, is a *cholinesterase* inhibitor (AChE (IC₅₀ = 0.54 μM), BChE (IC₅₀ = 3.32 μM)). Groenlandicine non-competitively inhibits BACE1 (IC₅₀ = 19.68 μM, K_i = 21.2) and inhibits RLAR (IC₅₀ = 140.1 μM), HRAR (IC₅₀ = 154.2 μM), and total ROS generation (IC₅₀ = 51.78 μM) in vitro. Groenlandicine suppresses osteosarcoma cell proliferation while promoting apoptosis. Groenlandicine inhibits the tumor growth when combined with Cisplatin (HY-17394). Groenlandicine can be used for the study on osteosarcoma, Alzheimer's disease and diabetes mellitus .

HY-N12581

Kuwanon U	Flavonoids Flavonones Morus alba L. Plants Moraceae Source Classification	Cholinesterase (ChE)
Kuwanon U is a potent *cholinesterase* inhibitor with IC₅₀s of 19.69, 10.11 µM and K_is of 6.48, 9.59 µM for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), respectively. Kuwanon U has the potential for the research of Alzheimer’s disease (AD) .

HY-N15710

Magnotriol B	Magnoliaceae Houpoea officinalis (Rehder & E. H. Wilson) N. H. Xia & C. Y. Wu Phenols Polyphenols Plants Source Classification	Cholinesterase (ChE)
Magnotriol B is a *cholinesterase inhibitor* with IC₅₀ values of 12.63 nM and 14.5 nM against AChE and BChE, respectively. Magnotriol B also exhibits significant NO inhibitory activity with an IC₅₀ of 2.02 μM. Magnotriol B can be used in the research of neurodegenerative and inflammatory diseases .

Cat. No.	Product Name	Chemical Structure

HY-B0207AS

Pyridostigmine-d6 bromide
Pyridostigmine-d₆ (bromide) is the deuterium labeled Pyridostigmine, which is a parasympathomimetic and a reversible cholinesterase inhibitor.

HY-11017AS

(S)-Rivastigmine-d6 tartrate
(S)-Rivastigmine-d₆ (tartrate) is the deuterium labeled (S)-Rivastigmine, which is an cholinesterase inhibitor.

HY-B0207AS1

Pyridostigmine-d3 bromide
Pyridostigmine-d₃ (bromide) is the deuterium labeled Pyridostigmine bromide. Pyridostigmine bromide is a parasympathomimetic and a reversible cholinesterase inhibitor.

HY-W027553S1

Ipidacrine-d9
Ipidacrine-d₉ (NIK-247-d₉ (free base)) is the deuterium labeled Ipidacrine (HY-W027553). Ipidacrine is orally active and brain-penetrant AChE and BuChE inhibitors with IC₅₀ values of 1 μM and 1.9 μM, respectively, which is also a partial agonist of M2-cholinergic receptors and a reversible cholinesterase inhibitor. Ipidacrine has a stimulating effect on neuromuscular transmission and excitation along the nerve fibres with a moderately anti-pain effect. Ipidacrine is an aminopyridines and is structurally similar to Tacrine (HY-111338). Ipidacrine is effective in various amnesia models, improves erectile function and inhibits K+ and Na+-channels in the neuronal membrane in diabetic rats. Ipidacrine is promising for research of Alzheimer’s disease, ischaemic stroke, idiopathic neuropathy of the facial nerve, diabetes mellitus-induced erectile dysfunction and other deficits in central or peripheral cholinergic deseases .

Ipidacrine-d9

Ipidacrine-d₉ (NIK-247-d₉ (free base)) is the deuterium labeled Ipidacrine (HY-W027553). Ipidacrine is orally active and brain-penetrant AChE and BuChE inhibitors with IC₅₀ values of 1 μM and 1.9 μM, respectively, which is also a partial agonist of M2-cholinergic receptors and a reversible cholinesterase inhibitor. Ipidacrine has a stimulating effect on neuromuscular transmission and excitation along the nerve fibres with a moderately anti-pain effect. Ipidacrine is an aminopyridines and is structurally similar to Tacrine (HY-111338). Ipidacrine is effective in various amnesia models, improves erectile function and inhibits K+ and Na+-channels in the neuronal membrane in diabetic rats. Ipidacrine is promising for research of Alzheimer’s disease, ischaemic stroke, idiopathic neuropathy of the facial nerve, diabetes mellitus-induced erectile dysfunction and other deficits in central or peripheral cholinergic deseases .

HY-W011246S

Velnacrine-d3-1 maleate
Velnacrine-d₃-1 maleate (HP 029-d₃-1) is the deuterium labeled Velnacrine maleate (HY-W011246). Velnacrine maleate (HP 029) is an orally active cholinesterase inhibitor that can be used for the research of Alzheimer's disease .

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Cholinesterase+Inhibitors

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products