AChE-IN-109
AChE-IN-109 is a potent mixed-type cholinesterase inhibitor with significantly stronger inhibitory activity against AChE than BChE. AChE-IN-109 has IC50 values of 0.55 μM and 12.45 μM against AChE and BChE, respectively. AChE-IN-109 inhibits cholinesterases through a mixed-type mechanism, binds to both the catalytic active site (CAS) and peripheral anionic site (PAS) of AChE. AChE-IN-109 can be used for the study of Alzheimer’s disease (AD).
For research use only. We do not sell to patients.
- Formula: C28H31N7O2
- Molecular Weight:497.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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AChE 0.55 μM (IC50) |
BChE 12.45 μM (IC50) |
AChE-IN-109 (11n) (10 min pre-incubation; 10 min reaction) potently inhibits electric eel acetylcholinesterase with an IC50 of 0.55 μM and horse serum butyrylcholinesterase with an IC50 of 12.45 μM, exhibiting 22.43-fold selectivity over horse serum butyrylcholinesterase[1].
AChE-IN-109 functions as a mixed-type inhibitor that binds to both the catalytic active site (CAS) and peripheral anionic site (PAS) of AChE[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 497.59
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Formula C28H31N7O2
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SMILES
O=[N+](C1=CC=C(C2=NC(NCCCN3CCN(CC4=CC=CC=C4)CC3)=NN2C5=CC=CC=C5)C=C1)[O-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE-IN-109 Related Classifications
HY-181851 Related Classifications
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