1. Neuronal Signaling
  2. AChE
  3. Demecarium Bromide

Demecarium Bromide (Synonyms: BC-48)

Cat. No.: HY-B1626A
Handling Instructions

Demecarium Bromide (BC-48) is a potent cholinesterase inhibitor, with an apparent affinity (Kiapp) of 0.15 μM. Demecarium Bromide (BC-48) is used as a glaucoma agent.

For research use only. We do not sell to patients.

Demecarium Bromide Chemical Structure

Demecarium Bromide Chemical Structure

CAS No. : 56-94-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 95 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
25 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

Demecarium Bromide (BC-48) is a potent cholinesterase inhibitor, with an apparent affinity (Kiapp) of 0.15 μM[1]. Demecarium Bromide (BC-48) is used as a glaucoma agent[2].

IC50 & Target

Kiapp: 0.15 μM (Cholinesterase)[1]

In Vivo

Demecarium Bromide (0.125 and 0.5%) causes long-term miosis and decreases intraocular pressure (IOP) in beagles with both normotensive eyes and inherited glaucoma[1].

Storage

4°C, protect from light

Solvent & Solubility
In Vitro: 

DMSO : 160 mg/mL (223.28 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3955 mL 6.9775 mL 13.9550 mL
5 mM 0.2791 mL 1.3955 mL 2.7910 mL
10 mM 0.1395 mL 0.6977 mL 1.3955 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.67 mg/mL (3.73 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.67 mg/mL (3.73 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.67 mg/mL (3.73 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

716.59

Formula

C₃₂H₅₂Br₂N₄O₄

CAS No.

56-94-0

SMILES

O=C(N(CCCCCCCCCCN(C(OC1=CC([N+](C)(C)C)=CC=C1)=O)C)C)OC2=CC([N+](C)(C)C)=CC=C2.[Br-].[Br-]

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Demecarium Bromide
Cat. No.:
HY-B1626A
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Demecarium Bromide

Cat. No.: HY-B1626A