56-94-0
56-94-0
Chemical Structure
Demecarium Bromide
Synonym(s): BC-48
- CAS No.: 56-94-0
- Formula:C32H52Br2N4O4
- Molecular Weight:716.59
IUPAC Name: 3,3'-(((decane-1,10-diylbis(methylazanediyl))bis(carbonyl))bis(oxy))bis(N,N,N-trimethylbenzenaminium) bromide
InChIKey: YHKBUDZECQDYBR-UHFFFAOYSA-L
SMILES: O=C(N(CCCCCCCCCCN(C(OC1=CC([N+](C)(C)C)=CC=C1)=O)C)C)OC2=CC([N+](C)(C)C)=CC=C2.[Br-].[Br-]
Biological Activity: Demecarium Bromide (BC-48) is a potent cholinesterase inhibitor, with an apparent affinity (Kiapp) of 0.15 μM[1]. Demecarium Bromide (BC-48) is used as a glaucoma agent[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Demecarium Bromide | 95.0% | Demecarium Bromide (BC-48) is a potent cholinesterase inhibitor, with an apparent affinity (Kiapp) of 0.15 μM. Demecarium Bromide (BC-48) is used as a glaucoma agent. | ||||||||||||||||||||
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Demecarium Bromide (Standard) | ≥98% | Demecarium Bromide (Standard) is the analytical standard of Demecarium Bromide. This product is intended for research and analytical applications. Demecarium Bromide (BC-48) is a potent cholinesterase inhibitor, with an apparent affinity (Kiapp) of 0.15 μM. Demecarium Bromide (BC-48) is used as a glaucoma agent. | ||||||||||||||||||||
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Symetine dihydrochloride | Symetine dihydrochloride (L 16726 dihydrochloride) is the dihydrochloride form of Symetine (HY-101590). Symetine dihydrochloride exhibits antiprotozoal activity aginst Entamoeba histolytica, and ameliorates the amebic liver abscess in guinea pig model. | |||||||||||||||||||||
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Ubretid | 98.80% | Ubretid is a potent inhibitor of plasma cholinesterase. Ubretid therefore delays the hydrolysis of suxamethonium and prolongs its action, similar to the effects shown by other anticholinesterase agents, such as pyridostigmine and donepezil. Ubretid has the potential for the research of urinary retention prolongs the effect of suxamethonium. Ubretid is commonly prescribed for the research of myasthenia gravis and for difficulty in emptying the bladder. | ||||||||||||||||||||
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Neostigmine hydroxide | Neostigmine hydroxide is a cholinesterase inhibitor and can be used for study of myasthenia gravis. | |||||||||||||||||||||
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JP104 | 99.67% | JP104, a aryl carbamate, is an irreversible FAAH inhibitor with a pIC50 of ~8. | ||||||||||||||||||||
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Neostigmine iodide | Neostigmine iodide is a reversible acetylcholinesterase inhibitor with muscle tone-enhancing activity. Neostigmine iodide is primarily used to improve muscle function in patients with myasthenia gravis. Neostigmine iodide is also used in routine anesthesia to reverse the effects of nondepolarizing muscle relaxants such as rocuronium. | |||||||||||||||||||||
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Neostigmine Bromide (Standard) | ≥98% | Neostigmine (Bromide) (Standard) is the analytical standard of Neostigmine (Bromide). This product is intended for research and analytical applications. Neostigmine Bromide is a cholinesterase inhibitor that acts on myasthenia gravis. | ||||||||||||||||||||
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Neostigmine (methyl sulfate) | 99.50% | Neostigmine methyl sulfate is an AchE inhibitor. Neostigmine methyl sulfate increases endogenous acetylcholine levels, mediates antinociceptive effects, and alleviates heat-induced pain. Neostigmine methyl sulfate can be used in studies related to postoperative pain and sepsis. | ||||||||||||||||||||
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2-Naphthyl laurate | 2-Naphthyl Laurate is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | |||||||||||||||||||||
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2-Naphthyl myristate | 2-Naphthyl Myristate is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | |||||||||||||||||||||
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Di(pyridin-3-yl) hexane-1,6-diylbis(methylcarbamate) | Di(pyridin-3-yl) hexane-1,6-diylbis(methylcarbamate) is a metal-organic framework (MOF). | |||||||||||||||||||||
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References
- [1]. Brown JH, et al. Activation and blockade of cardiac muscarinic receptors by endogenous acetylcholine and cholinesterase inhibitors. J Pharmacol Exp Ther. 1982 Oct;223(1):20-4. [Content Brief]
- [2]. Gum GG, et al. Effect of topically applied demecarium bromide and echothiophate iodide on intraocular pressure and pupil size in beagles with normotensive eyes and beagles with inherited glaucoma. Am J Vet Res. 1993 Feb;54(2):287-93. [Content Brief]
