Ubretid
Based on 1 Customer Validation
Ubretid is a potent inhibitor of plasma cholinesterase. Ubretid therefore delays the hydrolysis of suxamethonium and prolongs its action, similar to the effects shown by other anticholinesterase agents, such as pyridostigmine and donepezil. Ubretid has the potential for the research of urinary retention prolongs the effect of suxamethonium. Ubretid is commonly prescribed for the research of myasthenia gravis and for difficulty in emptying the bladder.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.80%
- CAS 番号: 15876-67-2
- 分子式: C22H32Br2N4O4
- 分子量:576.32
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
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AChE 0.25 μM (IC50) |
BChE 0.27 μM (IC50) |
体外実験
Ubretid inhibits AChE and BChE (IC50s are 0.25 μM and 0.27 μM), increases the level of acetylcholine, activates cholinergic neural pathways, thereby regulating neuronal excitability and synaptic transmission[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats models[2]
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Dosage:50-100 μg/kg
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Administration:ip, single dose
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Result:Increased the level of acetylcholine in the medial prefrontal cortex of rats.
Decreased the motor activity and induced cholinergic behaviors such as tremor, fasciculation, and tearing.
化学情報
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CAS 番号 15876-67-2
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性状 Solid
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分子量 576.32
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分子式 C22H32Br2N4O4
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Color White to light yellow
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SMILES
O=C(N(C)CCCCCCN(C)C(OC1=C[N+](C)=CC=C1)=O)OC2=C[N+](C)=CC=C2.[Br-].[Br-]
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別名
Distigmine dibromide
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (173.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (269 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Isono S, et al. Ubretid (distigmine bromide) taken to treat urinary retention prolongs the effect of suxamethonium. J Anesth. 2008;22(3):337. [Content Brief]
[2]. Nakayama K, et al., Effect of distigmine bromide on the central cholinergic system. J Psychopharmacol. 2009 Mar;23(2):190-3. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7351 mL | 8.6757 mL | 17.3515 mL | 43.3787 mL |
| 5 mM | 0.3470 mL | 1.7351 mL | 3.4703 mL | 8.6757 mL | |
| 10 mM | 0.1735 mL | 0.8676 mL | 1.7351 mL | 4.3379 mL | |
| 15 mM | 0.1157 mL | 0.5784 mL | 1.1568 mL | 2.8919 mL | |
| 20 mM | 0.0868 mL | 0.4338 mL | 0.8676 mL | 2.1689 mL | |
| 25 mM | 0.0694 mL | 0.3470 mL | 0.6941 mL | 1.7351 mL | |
| 30 mM | 0.0578 mL | 0.2892 mL | 0.5784 mL | 1.4460 mL | |
| 40 mM | 0.0434 mL | 0.2169 mL | 0.4338 mL | 1.0845 mL | |
| 50 mM | 0.0347 mL | 0.1735 mL | 0.3470 mL | 0.8676 mL | |
| 60 mM | 0.0289 mL | 0.1446 mL | 0.2892 mL | 0.7230 mL | |
| 80 mM | 0.0217 mL | 0.1084 mL | 0.2169 mL | 0.5422 mL | |
| 100 mM | 0.0174 mL | 0.0868 mL | 0.1735 mL | 0.4338 mL |
Ubretid 関連分類
HY-119577 関連分類
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