2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel Cholinesterase (ChE)
  4. Multi-kinase-IN-10

Multi-kinase-IN-10 (Compound IIIk) is a multi-kinase inhibitor. Multi-kinase-IN-10 exhibits significant calcium channel blocking activity, with its IC50 being 26.67 μM. Multi-kinase-IN-10 is a potent dual cholinesterase inhibitor, with its IC50 values for hAChE and hBuChE being 0.304 μM and 1.033 μM respectively. Multi-kinase-IN-10 has antioxidant and neuroprotective activities, and shows significant anti-amnesia activity. Multi-kinase-IN-10 can be used for research on Alzheimer's disease.

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Multi-kinase-IN-10

Multi-kinase-IN-10 Chemical Structure

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Multi-kinase-IN-10 Related Antibodies

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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AChE BChE

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Description

Multi-kinase-IN-10 (Compound IIIk) is a multi-kinase inhibitor. Multi-kinase-IN-10 exhibits significant calcium channel blocking activity, with its IC50 being 26.67 μM. Multi-kinase-IN-10 is a potent dual cholinesterase inhibitor, with its IC50 values for hAChE and hBuChE being 0.304 μM and 1.033 μM respectively. Multi-kinase-IN-10 has antioxidant and neuroprotective activities, and shows significant anti-amnesia activity. Multi-kinase-IN-10 can be used for research on Alzheimer's disease[1].

IC50 & Target[1]

CaV1.1

26.67 μM (IC50)

hAChE

0.304 μM (IC50)

hBCHE

1.033 μM (IC50)

Molecular Weight

750.08

Formula

C36H38BrClN6O5
SMILES

O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=C(OCC3=CN(CCCNC4=C(CCCC5)C5=NC6=CC=C(Cl)C=C64)N=N3)C(Br)=C2)OC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Multi-kinase-IN-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Multi-kinase-IN-10Calcium ChannelCholinesterase (ChE)Ca2+ channelsCa channelsAlzheimer's diseaseMTDLmulticomponent reactionclick reactiongreen chemistryCholinesterase inhibitorsCalcium channel blockadeNeuroprotectionInhibitorinhibitorinhibit

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