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IMPDH inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	IMPDH (11) Antibiotic (7) Apoptosis (7) Arenavirus (1) Bacterial (8) Bcl-2 Family (1) Caspase (1) Dengue Virus (5) DNA/RNA Synthesis (1) Drug Metabolite (3) Endogenous Metabolite (6) Flavivirus (7) Fungal (5) HBV (1) HCV (3) HDAC (1) Isotope-Labeled Compounds (2) MDM-2/p53 (1) Nucleoside Antimetabolite/Analog (1) Orthopoxvirus (1) Parasite (4) Reference Standards (3) SARS-CoV (2) Sirtuin (1)
By Research Areas:	Cancer (16) Infection (12) Inflammation/Immunology (9) Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: IMPDH

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0199

Mycophenolate Mofetil 10+ Cited Publications RS 61443; TM-MMF	Drug Metabolite Apoptosis Endogenous Metabolite Bacterial	Cancer
Mycophenolate mofetil (RS 61443) is the morpholinoethylester proagent of Mycophenolic acid. Mycophenolate mofetil inhibits de novo purine synthesis via the inhibition of inosine monophosphate dehydrogenase (IMPDH). Mycophenolate mofetil shows selective lymphocyte antiproliferative effects involve both T and B cells, preventing antibody formation .

HY-B0421

Mycophenolic acid Maximum Cited Publications 14 Publications Verification Mycophenolate	Dengue Virus Apoptosis Bacterial Fungal Endogenous Metabolite Antibiotic Flavivirus	Infection Inflammation/Immunology Cancer
Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC₅₀ of 0.24 µM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects .

HY-13560

AVN-944 5 Publications Verification VX-944	Arenavirus DNA/RNA Synthesis Apoptosis Caspase Bcl-2 Family	Infection Cancer
AVN-944 (VX-944) is an orally active, potent, selective, noncompetitive and specific inhibitor of *IMPDH* (inosine monophosphate dehydrogenase). AVN-944 is an essential rate-limiting enzyme in de novo guanine nucleotide synthesis. AVN-944 is also an inhibitor of arenavirus RNA synthesis, and blocks arenavirus infection. AVN-944 has broad anti-cancer activities, and can be used for multiple myeloma (MM) and acute myeloid leukemia (AML) research .

HY-17470

Mizoribine 5 Publications Verification NSC 289637; HE 69	HCV SARS-CoV Antibiotic Parasite	Inflammation/Immunology
Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC₅₀ of approximately 100 μM for anti-HCV activity. Immunosuppressant . Mizoribine, an *IMPDH* inhibitor, inhibits replication of SARS-CoV with IC₅₀s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively .

HY-13986

Merimepodib 2 Publications Verification VX-497; MMPD	Flavivirus Dengue Virus HBV HCV	Infection Cancer
Merimepodib (VX-497) is a noncompetitive and oral inhibitor of inosine monophosphate dehydrogenase (IMPDH) with broad spectrum antiviral activities.

HY-B0421S

Mycophenolic acid-d3 Mycophenolate-d₃	Bacterial Apoptosis Fungal Antibiotic Endogenous Metabolite Isotope-Labeled Compounds Flavivirus	Others
Mycophenolic acid-d₃ (Mycophenolate-d₃) is deuterium labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC₅₀ of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.

HY-15869

Inauhzin 3 Publications Verification INZ	Sirtuin MDM-2/p53	Cancer
Inauhzin is a dual *SirT1/IMPDH2* inhibitor, and acts as an activator p53, used in the research of cancer.

HY-110217

BMS-566419	IMPDH	Inflammation/Immunology
BMS-566419 is an orally active *IMPDH* inhibitor with an IC₅₀ of 91 nM against human IMPDH I and 68 nM against human IMPDH II. BMS-566419 exerts anti-heart transplant rejection and anti-renal fibrosis effects, and inhibits the expression of MCP-1, TGF-β1 as well as antibody production. BMS-566419 can be used in research on renal fibrosis and organ transplantation .

HY-145286

IMPDH2-IN-2	Bacterial	Infection Cancer
IMPDH2-IN-2 is a potent inhibitor of inosine 5’-monophosphate dehydrogenase (IMPDH) with a K_i,app value of 14 μM, respectively. IMPDH2-IN-2 displays moderate antibacterial activity (MIC = 6.3 and 11 μM in minimal GAST/Fe and rich 7H9/ADC/Tween media, respectively). IMPDH2-IN-2 is a potential anti-tuberculosis agent .

HY-13986A

(R)-Merimepodib (R)-VX-497; (R)-MMPD	IMPDH	Infection
(R)-Merimepodib is the isomer of Merimepodib (HY-13986), and can be used as an experimental control. Merimepodib (VX-497) is a noncompetitive and oral inhibitor of inosine monophosphate dehydrogenase (IMPDH) with broad spectrum antiviral activities.

HY-B0421A

Mycophenolic acid sodium Maximum Cited Publications 14 Publications Verification Mycophenolate sodium	Dengue Virus Apoptosis Bacterial Fungal Antibiotic Endogenous Metabolite Flavivirus	Infection Inflammation/Immunology Cancer
Mycophenolic acid sodium is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC₅₀ of 0.24 µM. Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid sodium is an immunosuppressive agent. Antiangiogenic and antitumor effects .

HY-W700392

IMPDH-IN-2	IMPDH	Cancer
IMPDH-IN-2 (compound 2) is an inhibitor of inosine monophosphate dehydrogenase (IMPDH) with *IC₅₀IMPDH I and IMPDH* II >*Values are 0.15 and 0.17 μM, respectively. IMPDH*-IN-2 has antitumor activity .

HY-114570

Tiazofurin 1 Publications Verification NSC 286193; Riboxamide	Nucleoside Antimetabolite/Analog Orthopoxvirus	Infection Neurological Disease Cancer
Tiazofurin (NSC 286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH). Tiazofurin enhances the autosecretion of IL-6 in K562 cells. Tiazofurin also has anti-orthopoxvirus and anti-variola activities. Tiazofurin can be used for the study of leukemia and lung cancer .

HY-117124

BMS-337197	IMPDH	Others
BMS-337197 is an inosine monophosphate dehydrogenase (IMPDH) inhibitor .

HY-B0421R

Mycophenolic acid (Standard) Mycophenolate (Standard)	Dengue Virus Reference Standards Apoptosis Bacterial Fungal Endogenous Metabolite Antibiotic Flavivirus	Infection Inflammation/Immunology Cancer
Mycophenolic acid (Standard) is the analytical standard of Mycophenolic acid. This product is intended for research and analytical applications. Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM.?Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects .

HY-147342

β-Benzamide adenine dinucleotide	Drug Metabolite IMPDH	Cancer
β-Benzamide adenine dinucleotide is a biologically active metabolite of benzamide riboside. β-Benzamide adenine dinucleotide is a competitive inhibitor of human NAD kinase with a K_i value of 90 μM, and inhibits human *IMPDH* with IC₅₀ values of 0.787 μM and 0.884 μM for type I and type II, respectively. β-Benzamide adenine dinucleotide exhibits inhibitory activities against lactate dehydrogenase, glutamate dehydrogenase, and malate dehydrogenase. β-Benzamide adenine dinucleotide can be used for the study of chronic myelogenous leukemia .

HY-168509

IMPDH-IN-1	Bacterial	Infection
IMPDH-IN-1 (compound 44) is a bacterial inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitor. IMPDH-IN-1 specifically binds to the catalytic domain of IMPDH. IMPDH-IN-1 potently inhibits the IMPDH of Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli .

HY-169296

IMPDH2-IN-4	IMPDH	Cancer
IMPDH2-IN-4 (Compound 2d) is a selective *IMPDH2* inhibitor with a K_i,app value of 1.8 μM. IMPDH2-IN-4 exhibits anti-cancer activity against osteosarcoma. IMPDH2-IN-4 can be used in research related to osteosarcoma .

HY-161712

IMPDH-IN-4	IMPDH	Cancer
IMPDH-IN-4 is a derivative of N-pyridinylthiophene carboxamid that exhibits activity against peripheral nerve sheath carcinoma cells. IMPDH-IN-4 is metabolized by NAMPT and NMNAT1 to an adenine dinucleotide (AD) derivative, which is an NAD analog and can inhibit inosine monophosphate dehydrogenase (IMPDH), leading to the accumulation of inosine monophosphate (IMP) in cells. IMPDH-IN-4 has good blood-brain barrier permeability and can be used in the study of central and peripheral nervous system cancers .

HY-17470R

Mizoribine (Standard) NSC 289637 (Standard); HE 69 (Standard)	Reference Standards HCV SARS-CoV Antibiotic Parasite	Inflammation/Immunology
Mizoribine (Standard) is the analytical standard of Mizoribine. This product is intended for research and analytical applications. Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC₅₀ of approximately 100 μM for anti-HCV activity. Immunosuppressant . Mizoribine, an *IMPDH* inhibitor, inhibits replication of SARS-CoV with IC₅₀s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively .

HY-128214

IMPDH-IN-3	IMPDH Parasite	Infection
IMPDH-IN-3 (Compound C67) is an inhibitor of C. parvum IMPDH (CpIMPDH) with an IC₅₀ of 35 nM. IMPDH-IN-3 can be used in the research of anti-Cryptosporidium drugs .

HY-174221

IMPDH II/HDAC1-IN-1	IMPDH HDAC	Cancer
IMPDH II/HDAC1-IN-1 (Compound C12) is an orally active, selective dual IMPDH II/HDAC1 inhibitor, with an IC₅₀ of 84.69 nM against hIMPDH II and an IC₅₀ of 81.75 nM against HDAC1. IMPDH II/HDAC1-IN-1 inhibits the proliferation of chronic myeloid leukemia cells. IMPDH II/HDAC1-IN-1 can be used for the research of chronic myeloid leukemia .

HY-118917

VX-148	IMPDH	Inflammation/Immunology
VX-148 is an orally active immunosuppressant, which is a non-competitive inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor with K_i values for IMPDH Ⅱ and IMPDH Ⅰ of 6 and 14 nM respectively. VX-148 can significantly inhibit the proliferation of human peripheral blood mononuclear cells (PBMC) stimulated by T-cell mitogen (PHA) or B-cell mitogen (SPAS). VX-148 has high selectivity for lymphocytes (such as L1210, Jurkat T cells, and Raji B cells), but has no significant toxicity to non-lymphoid cells. VX-148 can inhibit antibody responses in mouse models and significantly prolong the survival time of transplanted skin in allogeneic skin transplantation models. VX-148 can be used in the research of autoimmune diseases (such as rheumatoid arthritis, psoriasis) and organ transplantation anti-rejection .

HY-B0421S2

Mycophenolic acid-13C17 Mycophenolate-¹³C₁₇	Isotope-Labeled Compounds Flavivirus	Cancer
Mycophenolic acid-13C17 (Mycophenolate-13C17) is the 13C labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.

HY-B0421AR

Mycophenolic acid sodium (Standard) Mycophenolate sodium (Standard)	Dengue Virus Reference Standards Apoptosis Bacterial Fungal Antibiotic Endogenous Metabolite Flavivirus	Infection Inflammation/Immunology Cancer
Mycophenolic acid (sodium) (Standard) is the analytical standard of Mycophenolic acid (sodium). This product is intended for research and analytical applications. Mycophenolic acid sodium is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid sodium is an immunosuppressive agent. Antiangiogenic and antitumor effects .

HY-W743767

Mizoribine 5'-monophosphate MZR-P	IMPDH Parasite Drug Metabolite	Infection Inflammation/Immunology
Mizoribine 5'-monophosphate (MZR-P) is the active metabolite of Mizoribine (HY-17470). Mizoribine 5'-monophosphate is an inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH), and its K_i values for IMPDH of Trypanosoma brucei, Bacillus subtilis and Oceanobacillus iheyensis are 3.3, 72 and 157 nM respectively. Mizoribine 5'-monophosphate can be used in anti-trypanosomiasis and immunosuppression research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0199

Mycophenolate Mofetil 10+ Cited Publications RS 61443; TM-MMF	Monophenols Classification of Application Fields Phenols Endogenous metabolite Disease Research Fields Source Classification Cancer	Drug Metabolite Apoptosis Endogenous Metabolite Bacterial
Mycophenolate mofetil (RS 61443) is the morpholinoethylester proagent of Mycophenolic acid. Mycophenolate mofetil inhibits de novo purine synthesis via the inhibition of inosine monophosphate dehydrogenase (IMPDH). Mycophenolate mofetil shows selective lymphocyte antiproliferative effects involve both T and B cells, preventing antibody formation .

HY-B0421

Mycophenolic acid Maximum Cited Publications 14 Publications Verification Mycophenolate	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Dengue Virus Apoptosis Bacterial Fungal Endogenous Metabolite Antibiotic Flavivirus
Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC₅₀ of 0.24 µM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects .

HY-17470

Mizoribine 5 Publications Verification NSC 289637; HE 69	Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Inflammation/Immunology Disease Research Fields Source Classification	HCV SARS-CoV Antibiotic Parasite
Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC₅₀ of approximately 100 μM for anti-HCV activity. Immunosuppressant . Mizoribine, an *IMPDH* inhibitor, inhibits replication of SARS-CoV with IC₅₀s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively .

HY-B0421A

Mycophenolic acid sodium Maximum Cited Publications 14 Publications Verification Mycophenolate sodium	Infection Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Phenols Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification Cancer	Dengue Virus Apoptosis Bacterial Fungal Antibiotic Endogenous Metabolite Flavivirus
Mycophenolic acid sodium is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC₅₀ of 0.24 µM. Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid sodium is an immunosuppressive agent. Antiangiogenic and antitumor effects .

HY-B0421R

Mycophenolic acid (Standard) Mycophenolate (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Dengue Virus Reference Standards Apoptosis Bacterial Fungal Endogenous Metabolite Antibiotic Flavivirus
Mycophenolic acid (Standard) is the analytical standard of Mycophenolic acid. This product is intended for research and analytical applications. Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM.?Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects .

HY-17470R

Mizoribine (Standard) NSC 289637 (Standard); HE 69 (Standard)	Alkaloids Structural Classification Microorganisms Other Alkaloids Source Classification	Reference Standards HCV SARS-CoV Antibiotic Parasite
Mizoribine (Standard) is the analytical standard of Mizoribine. This product is intended for research and analytical applications. Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC₅₀ of approximately 100 μM for anti-HCV activity. Immunosuppressant . Mizoribine, an *IMPDH* inhibitor, inhibits replication of SARS-CoV with IC₅₀s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively .

HY-B0421AR

Mycophenolic acid sodium (Standard) Mycophenolate sodium (Standard)	Structural Classification Monophenols Ketones, Aldehydes, Acids Phenols Endogenous metabolite Source Classification	Dengue Virus Reference Standards Apoptosis Bacterial Fungal Antibiotic Endogenous Metabolite Flavivirus
Mycophenolic acid (sodium) (Standard) is the analytical standard of Mycophenolic acid (sodium). This product is intended for research and analytical applications. Mycophenolic acid sodium is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid sodium is an immunosuppressive agent. Antiangiogenic and antitumor effects .

Cat. No.	Product Name	Chemical Structure

HY-B0421S

Mycophenolic acid-d3
Mycophenolic acid-d₃ (Mycophenolate-d₃) is deuterium labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC₅₀ of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.

Mycophenolic acid-d3

Mycophenolic acid-d₃ (Mycophenolate-d₃) is deuterium labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC₅₀ of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.

HY-B0421S2

Mycophenolic acid-13C17
Mycophenolic acid-13C17 (Mycophenolate-13C17) is the 13C labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.

Mycophenolic acid-13C17

Mycophenolic acid-13C17 (Mycophenolate-13C17) is the 13C labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.

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