IMPDH2-IN-4
IMPDH2-IN-4 (Compound 2d) is a selective IMPDH2 inhibitor with a Ki,app value of 1.8 μM. IMPDH2-IN-4 exhibits anti-cancer activity against osteosarcoma. IMPDH2-IN-4 can be used in research related to osteosarcoma.
For research use only. We do not sell to patients.
- Formula: C35H34O6Si
- Molecular Weight:578.73
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IMPDH2 1.8 μM (Ki app) |
IMPDH2-IN-4 (0.1-100.0 μM for hFOB; 72 h) potently inhibits the viability of 143B, MNNG/HOS, U2OS and SaOS-2 osteosarcoma cells, with IC50 values ranging from 0.64 to 2.27 μM, while exhibiting low cytotoxicity toward normal osteoblastic hFOB 1.19 cells[1].
IMPDH2-IN-4 inhibits recombinant IMPDH2 with a Ki,app of 1.8 μM, and does not inhibit IMPDH1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:143B, MNNG/HOS, U2OS, SaOS-2, hFOB 1.19
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Concentration:0.1 μM, 1.0 μM, 10.0 μM, 100.0 μM for hFOB 1.19
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Incubation Time:72 h
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Result:Inhibited viability of 143B cells with an IC50 of 1.65 μM.
Inhibited viability of MNNG/HOS cells with an IC50 of 0.64 μM.
Inhibited viability of U2OS cells with an IC50 of 1.01 μM.
Inhibited viability of SaOS-2 cells with an IC50 of 2.27 μM.
Reduced hFOB 1.19 cell viability to 93.91% at 0.1 μM, 91.95% at 1.0 μM, 84.5% at 10.0 μM, and 73.34% at 100.0 μM.
Chemical Information
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Molecular Weight 578.73
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Formula C35H34O6Si
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SMILES
O=C(O[Si](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)CC/C(C)=C/CC4=C(O)C5=C(COC5=O)C(C)=C4OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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