2. Metabolic Enzyme/Protease
  3. IMPDH
  4. IMPDH2-IN-4

IMPDH2-IN-4 (Compound 2d) is a selective IMPDH2 inhibitor with a Ki,app value of 1.8 μM. IMPDH2-IN-4 exhibits anti-cancer activity against osteosarcoma. IMPDH2-IN-4 can be used in research related to osteosarcoma.

For research use only. We do not sell to patients.

IMPDH2-IN-4

IMPDH2-IN-4 Chemical Structure

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IMPDH2-IN-4 Related Antibodies

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Description

IMPDH2-IN-4 (Compound 2d) is a selective IMPDH2 inhibitor with a Ki,app value of 1.8 μM. IMPDH2-IN-4 exhibits anti-cancer activity against osteosarcoma. IMPDH2-IN-4 can be used in research related to osteosarcoma[1].

IC50 & Target[1]

IMPDH2

1.8 μM (Ki app)

In Vitro

IMPDH2-IN-4 (0.1-100.0 μM for hFOB; 72 h) potently inhibits the viability of 143B, MNNG/HOS, U2OS and SaOS-2 osteosarcoma cells, with IC50 values ranging from 0.64 to 2.27 μM, while exhibiting low cytotoxicity toward normal osteoblastic hFOB 1.19 cells[1].
IMPDH2-IN-4 inhibits recombinant IMPDH2 with a Ki,app of 1.8 μM, and does not inhibit IMPDH1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IMPDH2-IN-4 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: 143B, MNNG/HOS, U2OS, SaOS-2, hFOB 1.19
Concentration: 0.1 μM, 1.0 μM, 10.0 μM, 100.0 μM for hFOB 1.19
Incubation Time: 72 h
Result: Inhibited viability of 143B cells with an IC50 of 1.65 μM.
Inhibited viability of MNNG/HOS cells with an IC50 of 0.64 μM.
Inhibited viability of U2OS cells with an IC50 of 1.01 μM.
Inhibited viability of SaOS-2 cells with an IC50 of 2.27 μM.
Reduced hFOB 1.19 cell viability to 93.91% at 0.1 μM, 91.95% at 1.0 μM, 84.5% at 10.0 μM, and 73.34% at 100.0 μM.
Molecular Weight

578.73

Formula

C35H34O6Si
SMILES

O=C(O[Si](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)CC/C(C)=C/CC4=C(O)C5=C(COC5=O)C(C)=C4OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IMPDH2-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IMPDH2-IN-4IMPDHInosine-5’-monophosphate dehydrogenaseIMPDH1human normal osteoblast cellsMNNG/HOShFOB 1.19U2OS143Bosteosarcoma cancer cellsSaOS-2IMPDH2osteosarcomaInhibitorinhibitorinhibit

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