Cat. No.: HY-B0421A

Mycophenolic acid sodium

(Synonyms: Mycophenolate sodium)

14 Cited Publications

Customer Review

Based on 14 publication(s) in Google Scholar

Mycophenolic acid sodium is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC₅₀ of 0.24 µM. Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid sodium is an immunosuppressive agent. Antiangiogenic and antitumor effects.

For research use only. We do not sell to patients.

Purity: 99.98%
CAS No.: 37415-62-6
Formula: C₁₇H₁₉NaO₆
Molecular Weight:342.32

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Mycophenolic acid sodium Chemical Structure

CAS No.: 37415-62-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (14)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Human Endogenous Metabolite

All Antibiotic Isoforms :

All Endogenous Metabolite Isoforms :

In Vitro

Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza, dengue virus, Zika virus, rotavirus, CCHFV, and hantavirus^[1].
IMPDH is the rate-limiting enzyme in the de novo synthesis of guanosine nucleotides^[2].
Mycophenolic acid (0.01-1 μM; 72 hours) sodium exhibits preferential antiproliferative activity against the endothelial cells and fibroblasts. Endothelial cells are most sensitive cells to Mycophenolic acid treatment with an IC₅₀ <500 nM for antimitotic effects^[2].
Fibroblasts are also prone to Mycophenolic acid-induced cell cycle inhibition but exhibit a higher IC₅₀ (<1 μM) compared with endothelial cells. The two human tumor cell lines A549 non-small cell lung cancer cells and PC3 prostate cancer cells show intermediate sensitivity with an IC₅₀ >1 μM. U87 glioblastoma cells are resistant against Mycophenolic acid sodium treatment up to 1 μM^[2].
Mycophenolic acid (0.05-2 μM; 18 hours) sodium exhibits a dose-dependent down-regulation of HDAC2 and MYC, whereas up-regulates NDRG1^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:

Primary isolated human dermal microvascular endothelial cells (HDMVEC) , fibroblasts, U87 glioblastoma cells, PC3 prostate cancer cells, A549 non-small cell lung cancer cells.
Concentration:

0.01, 0.1, 1 μM
Incubation Time:

72 hours
Result:

Exhibited preferential antiproliferative activity against HDMVEC and fibroblasts. Whereas U87 glioblastoma cells were resistant to treatment, A549 non-small cell lung cancer and PC3 prostate cancer cells showed intermediate sensitivity.

Western Blot Analysis^[2]

Cell Line:

HDMVEC
Concentration:

0, 0.05, 0.1, 0.5, 1, and 2 μM
Incubation Time:

18 hours
Result:

Showed a dose-dependent regulation of HDAC2, MYC, and NDRG1.

In Vivo

Mycophenolic acid (120 mg/kg; oral gavage; b.i.d.) sodium exerts its antitumor effects via modulation of the tumor microenvironment, U87 tumor growth is markedly inhibited in vivo in BALB/c nude mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Athymic 8-week-old, 20 g BALB/c nu/nu mice bearing Mycophenolic acid-resistant human U87 tumor model^[2]
Dosage:

120 mg/kg MMF (the morpholinoethyl ester prodrug of Mycophenolic acid)
Administration:

Oral gavage; b.i.d.
Result:

MMF (the morpholinoethyl ester prodrug of Mycophenolic acid) significantly inhibited tumor growth (∼70% after day 14 after tumor implantation) in MMF-treated versus control mice.
Microvessel density (CD31 staining) and pericyte coverage determined by α-smooth muscle actin staining were markedly reduced in MMF-treated versus control tumors (44% and 78%, respectively).

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 37415-62-6
Appearance Solid
Molecular Weight 342.32
Formula C₁₇H₁₉NaO₆
Color White to off-white
SMILES

O=C(O[Na])CC/C(C)=C/CC1=C(O)C2=C(COC2=O)C(C)=C1OC
Synonyms

Mycophenolate sodium
Structure Classification
- Phenols
- Monophenols
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (14)

All WBFlow CytometryCell Proliferation/Viability AssayIF

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Journal Impact Factor

Nat Immunol

A method for predicting drugs that can boost the efficacy of immune checkpoint blockade. [Abstract]

2024 Apr;25(4):659-670. PMID: 38499799
Nat Commun

Nuclear IMPDH2 controls the DNA damage response by modulating PARP1 activity. [Abstract]

2024 Nov 12;15(1):9515. PMID: 39532854

Mycophenolic acid sodium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Nov 12;15(1):9515. [Abstract]

Mycophenolic acid (MPA) (0, 2.5, 7.5, 15 μM) treatment caused a dose-dependent increase of IMPDH2 protein levels.

Mycophenolic acid sodium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Nov 12;15(1):9515. [Abstract]

Mycophenolic acid (MPA) (0, 2.5, 7.5, 15 μM) treatment reduced viability at the highest concentration used (15 μM).

Mycophenolic acid sodium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Nov 12;15(1):9515. [Abstract]

HT-IF showed that there was a significant increase in ɣH2AX signal in Mycophenolic acid (MPA) treated cells already at 7.5 μM.
Sci Adv

12R-HETE acts as an endogenous ligand for Nur77 in the intestines and regulates NKp46+ ILC3 development. [Abstract]

2026 Feb 20;12(8):eadz8405. PMID: 41719391
J Transl Med

Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer. [Abstract]

2024 Feb 3;22(1):133. PMID: 38310229

Mycophenolic acid sodium purchased from MedChemExpress. Usage Cited in: J Transl Med. 2024 Feb 3;22(1):133. [Abstract]

The apoptotic rate was analysed after Mycophenolic acid (MPA) and/or oxaliplatin treatment compared with that of untreated cells for 24 h by flow cytosmetry analysis in HCT8/L-OHP cells.
Sci Signal

Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer. [Abstract]

2024 Nov 26;17(864):eadp1375. PMID: 39591412
J Agric Food Chem

Mechanism of Intestinal Epithelial Absorption and Electrophysiological Regulation of the Shrimp Peptide QMDDQ. [Abstract]

2024 Jan 10;72(1):326-338. PMID: 38155399
ACS Omega

Infectious cDNA Clone of Chikungunya Virus 181/25 for Antiviral Assay Development. [Abstract]

2025 Dec 8;10(50):62145-62156. PMID: 41476561

Mycophenolic acid sodium purchased from MedChemExpress. Usage Cited in: ACS Omega. 2025 Dec 8;10(50):62145-62156. [Abstract]

Dose response curves and % cell viability of mycophenolic acid (MPA) (10-100 μM) by MTT assay.
BMC Cancer

The integration of transcriptomics and metabolomics elucidates the antitumor mechanisms of mycophenolic acid in bladder cancer cells. [Abstract]

2025 Sep 30;25(1):1463. PMID: 41029501
Bone

HIF-1α mediates osteoclast-induced disuse osteoporosis via cytoophidia in the femur of mice. [Abstract]

2023 Mar:168:116648. PMID: 36563716
Viruses

Screening and Identification of Lujo Virus Inhibitors Using a Recombinant Reporter Virus Platform. [Abstract]

2021 Jun 28;13(7):1255. PMID: 34203149
PLoS Negl Trop Dis

Identification of anti-flaviviral drugs with mosquitocidal and anti-Zika virus activity in Aedes aegypti. [Abstract]

2019 Aug 20;13(8):e0007681. PMID: 31430351
J Viral Hepat

The Differential Effects of Immunosuppressants on Hepatitis E Virus Replication and the Triggered Inflammatory Responses in Macrophages. [Abstract]

2026 Jan;33(1):e70118. PMID: 41400072
SSRN

2025 Jul 9.
Curr Res Virol Sci

Identification of broad anti-coronavirus chemical agents for repurposing against SARS-CoV-2 and variants of concern. [Abstract]

2022;3:100019. PMID: 35072124

Solvent & Solubility

In Vitro:

DMSO : 175 mg/mL (511.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (292.12 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.9212 mL

14.6062 mL

29.2124 mL

5 mM

0.5842 mL

2.9212 mL

5.8425 mL

10 mM

0.2921 mL

1.4606 mL

2.9212 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (701 KB)
- English - EN (701 KB)
- Français - FR (701 KB)
- Deutsch - DE (701 KB)
- Norwegian - NO (701 KB)
- Español - ES (701 KB)
- Swedish - SV (701 KB)
- Italian - IT (701 KB)
- Korean - KR (701 KB)
- Portuguese - PT (701 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Stephen R Welch, et al. Screening and Identification of Lujo Virus Inhibitors Using a Recombinant Reporter Virus Platform. Viruses. 2021 Jun 28;13(7):1255. [Content Brief]

[2]. Sophie Domhan, et al. Molecular mechanisms of the antiangiogenic and antitumor effects of mycophenolic acid. Mol Cancer Ther. 2008 Jun;7(6):1656-68. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	2.9212 mL	14.6062 mL	29.2124 mL	73.0311 mL
	5 mM	0.5842 mL	2.9212 mL	5.8425 mL	14.6062 mL
	10 mM	0.2921 mL	1.4606 mL	2.9212 mL	7.3031 mL
	15 mM	0.1947 mL	0.9737 mL	1.9475 mL	4.8687 mL
	20 mM	0.1461 mL	0.7303 mL	1.4606 mL	3.6516 mL
	25 mM	0.1168 mL	0.5842 mL	1.1685 mL	2.9212 mL
	30 mM	0.0974 mL	0.4869 mL	0.9737 mL	2.4344 mL
	40 mM	0.0730 mL	0.3652 mL	0.7303 mL	1.8258 mL
	50 mM	0.0584 mL	0.2921 mL	0.5842 mL	1.4606 mL
	60 mM	0.0487 mL	0.2434 mL	0.4869 mL	1.2172 mL
	80 mM	0.0365 mL	0.1826 mL	0.3652 mL	0.9129 mL
	100 mM	0.0292 mL	0.1461 mL	0.2921 mL	0.7303 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Mycophenolic acid sodium

14 Cited Publications

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Mycophenolic acid sodium

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Publications Citing Use of MedChemExpress (MCE) Mycophenolic acid sodium

All Antibiotic Isoforms

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (14)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Mycophenolic acid sodium Related Classifications

HY-B0421A Related Classifications