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Mycobacterium smegmatis

" in MedChemExpress (MCE) Product Catalog:

標的別:	Antibiotic (6) Apoptosis (1) Bacterial (34) Biochemical Assay Reagents (1) DNA/RNA Synthesis (1) Endogenous Metabolite (1) Fatty Acid Synthase (FASN) (1) Fluorescent Dye (2) Fungal (1) mRNA (1) Parasite (4) Reactive Oxygen Species (ROS) (1) Reference Standards (1)
研究分野別:	Cancer (3) Infection (36) Inflammation/Immunology (2) Neurological Disease (1)

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蛍光色素

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天然物

製品番号	製品名	Target	研究分野	構造式

HY-13579

BTZ043 4 Publications Verification	Bacterial Antibiotic	Infection
BTZ043 is an inhibitor of decaprenyl-phosphoribose-epimerase (DprE1), with MICs of of 2.3 nM and 9.2 nM for M. tuberculosis H37Rv and Mycobacterium smegmatis, respectively.

HY-D2919

DMN-Tre	Fluorescent Dye	Infection
DMN-Tre is a conjugate of a solvatochromic fluorescent dye and trehalose. DMN-Tre takes advantage of the substrate promiscuity of the endogenous antigen 85 protein complex in mycobacteria to be metabolically integrated into the hydrophobic mycobacterial membrane. Once entering this hydrophobic environment, the linked DMN dye fluorescence is "turned on", enabling specific labeling . DMN-Tre can be used to reflect bacterial metabolic activity and support physiological studies of Mycobacterium tuberculosis .

HY-108964

Carvone	Bacterial	Infection Neurological Disease Inflammation/Immunology Cancer
Carvone is a ketone monoterpene found in the essential oils from plants of the genus Mentha. Carvone has such effects as anticancer, antimicrobial, antioxidant, anti-inflammatory, antispasmodic, antinociceptive, anticonvulsant .

HY-125576

Griselimycin	Bacterial	Infection
Griselimycin is a cyclic lipopeptide produced by Streptomyces. Griselimycin specifically binds to the sliding clamp of bacterial DNA polymerase and does not interact with human PCNA. Griselimycin exhibits potent antibacterial activity against Mycobacterium tuberculosis (including drug-resistant strains) and a variety of Gram-negative bacteria .

HY-122394

Thiolactomycin	Antibiotic Bacterial Fatty Acid Synthase (FASN)	Infection
Thiolactomycin is an orally active bacterial type II fatty acid synthase (FAS-II) inhibitor with antibacterial and antimalarial activities. Thiolactomycin specifically targets KasA/KasB in mycobacteria and FabB/FabF in bacteria, thereby inhibiting the biosynthesis of fatty acids and mycolic acids. Thiolactomycin can be used in studies related to tuberculosis, systemic bacterial infections, and experimental pyelonephritis .

HY-151549

Mtb-cyt-bd oxidase-IN-2	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-2 is an inhibitor of Mycobacterium tuberculosis cytochrome bd oxidase (Mtb cyt-bd oxidase) with an IC₅₀ value of 0.67 μM. Mtb-cyt-bd oxidase-IN-2 inhibits the growth of Mycobacterium tuberculosis with a MIC value of 256 μM. Mtb-cyt-bd oxidase-IN-2 can be used for the research of infection .

HY-N2544

Dehydroglaucine	Bacterial	Infection
Dehydroglaucine is a potent antimicrobial alkaloid .

HY-W995025

Actinobolin (+)-Actinobolin	Antibiotic Bacterial	Infection
Actinobolin ((+)-Actinobolin) is an antibiotic, that inhibits protein synthesis by targeting bacterial and eukaryotic ribosomes. Actinobolin inhibits Mycobacterium smegmatis, Escherichia coli and rabbit reticulocyte lysate (RRL) with an IC₅₀ of 19.2, 27.9, and 288 μmol/L, respectively .

HY-W995025A

Actinobolin hemisulfate (+)-Actinobolin hemisulfate	Antibiotic Bacterial	Infection
Actinobolin hemisulfate ((+)-Actinobolin hemisulfate) is the hemisulfate form of Actinobolin (HY-W995025). Actinobolin hemisulfate is an antibiotic, that inhibits protein synthesis by targeting bacterial and eukaryotic ribosomes. Actinobolin hemisulfate inhibits Mycobacterium smegmatis, Escherichia coli and rabbit reticulocyte lysate (RRL) with an IC₅₀ of 19.2, 27.9, and 288 μmol/L, respectively .

HY-120733

Calpinactam FKI-4905	Bacterial Endogenous Metabolite	Infection Inflammation/Immunology
Calpinactam (FKI-4905), a fungal metabolite, is a new anti-mycobacterial agent.Calpinactam is active only against Mycobacteria among various microorganisms, including Gram-positive and Gram-negative bacteria, fungi and yeasts. Calpinactam inhibits the growth of Mycobacterium smegmatis and Mycobacterium tuberculosis with MIC values of 0.78 and 12.5 μg/ml, respectively .

HY-161148

FtsZ-IN-9	Bacterial	Infection
FtsZ-IN-9 (compound 11) is an antimicrobial agent. FtsZ-IN-9 inhibits the assembly of Mycobacterium smegmatis FtsZ (MsFtsZ)_[1].

HY-149998

Antimycobacterial agent-5	Bacterial Reactive Oxygen Species (ROS) Apoptosis	Infection
Antimycobacterial agent-5 (compound 27) is an imidazopyridine amide targeting mycobacterial electron transport chain (ETC) airway CIII₂CIV₂ supercomplexes. The IC₅₀ value of Antimycobacterial agent-5 against Mycobacterium smegmatisCIII₂CIV₂ is 441 nM .

HY-151548

Mtb-cyt-bd oxidase-IN-1	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-1 (compound 1x) is a Mycobacterium tuberculosis cytochrome bd oxidase (Mtb cyt-bd oxidase) inhibitor with an IC₅₀ value of 0.13 μM. Mtb-cyt-bd oxidase-IN-1 can be used in tuberculosis research .

HY-151550

Mtb-cyt-bd oxidase-IN-3	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-3 (compound 1u) is a Mycobacterium tuberculosis cytochrome bd oxidase (Mtb cyt-bd oxidase) inhibitor with an IC₅₀ value of 0.36 μM. Mtb-cyt-bd oxidase-IN-3 inhibits the growth of Mycobacterium tuberculosis (MIC=32 μM). Mtb-cyt-bd oxidase-IN-3 can be used in tuberculosis research .

HY-13579R

BTZ043 (Standard)	Reference Standards Bacterial Antibiotic	Infection
BTZ043 (Standard) is the analytical standard of BTZ043. This product is intended for research and analytical applications. BTZ043 is an inhibitor of decaprenyl-phosphoribose-epimerase (DprE1), with MICs of of 2.3 nM and 9.2 nM for M. tuberculosis H37Rv and Mycobacterium smegmatis, respectively.

HY-146489

Anti-infective agent 3	Bacterial Parasite	Infection
Anti-infective agent 3 (compound 3l) shows antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC₅₀ values of 0.47 and 0.13 μM, respectively. Anti-infective agent 3 shows antimycobacterial activity against Mycobacterium smegmatis with a MIC of 4 μg/mL .

HY-146488

Anti-infective agent 2	Parasite Bacterial	Infection
Anti-infective agent 2 (compound 3k) shows antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC₅₀ values of 0.07 and 2.20 μM, respectively. Anti-infective agent 2 shows antimycobacterial activity against Mycobacterium smegmatis with a MIC of 32 μg/mL .

HY-146487

Anti-infective agent 1	Bacterial Parasite	Infection
Anti-infective agent 1 (compound 3a) is a potent and selective antiprotozoal and antimycobacterial agent. Anti-infective agent 1 shows antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC₅₀ values of 10.95 and 0.06 μM, respectively. Anti-infective agent 1 shows antimycobacterial activity against Mycobacterium smegmatis with a MIC of 8 μg/mL .

HY-151551

Mtb-cyt-bd oxidase-IN-4	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-4 (compound 1g) is a Mycobacterium tuberculosis cytochrome bd oxidase (Mtb cyt-bd oxidase) inhibitor with an IC₅₀ value of 0.25 μM. Mtb-cyt-bd oxidase-IN-4 inhibits the growth of Mycobacterium tuberculosis (MIC=8 μM). Mtb-cyt-bd oxidase-IN-4 can be used in tuberculosis research .

HY-D2729

Cy3-NO2-Tre	Fluorescent Dye	Infection
Cy3-NO2-Tre is a nitroreductase-responsive cyanine-based fluorescent probe that specifically labels Mycobacterium tuberculosis (Mtb). Cy3-NO2-tre generated fluorescence after activation by a specific nitroreductase, Rv3368c, which is conserved in the Mycobacteriaceae. Cy3-NO2-tre effectively imaged mycobacteria within infected host cells, tracked the infection process, and visualized Mycobacterium smegmatis being endocytosed by macrophages (Ex/Em= 540-550/575-625 nm) .

HY-161802

Antibacterial agent 228	Bacterial	Infection
Antibacterial agent 228 (Compound 8) inhibits the mycobacterial ribosome (IC₅₀ for Mycobacterium smegmatis is 2.31 μM) and exhibits antibacterial activity against M. tuberculosis H37Rv (MIC=2 and 0.25 μg/mL for wildtype and Δ1258c mutant), M. abscessus ATCC 19977 (MIC=8 and 8 μg/mL for wildtype and Δ2780c mutant) and M. smegmatis (MIC=8 μg/mL) .

HY-N18007

3-Hydroxyglabrol	Bacterial	Infection
3-Hydroxyglabrol is an Antibacterial agent. 3-Hydroxyglabrol can be isolated from Glycyrrhiza glabra L. var. typica. 3-Hydroxyglabrol inhibits the growth of Staphylococcus aureus (ATCC 13709) and Mycobacterium smegmatis (ATCC 607), with a MIC of 6.25 mcg/mL. 3-Hydroxyglabrol can be used for the research of Staphylococcus aureus infection, Mycobacterium smegmatis infection .

HY-W792760

(E)-2-(4-Cinnamoylphenoxy)acetic acid	Bacterial	Infection
(E)-2-(4-Cinnamoylphenoxy)acetic acid is an antimicrobial agent with a minimum inhibitory concentration of 125 μg/mL against Mycobacterium smegmatis, Staphylococcus aureus, and Candida albicans .

HY-126735

Saquayamycin D	Antibiotic Bacterial	Infection
Saquayamycin D is an antibiotic, which can be isolated from Streptomyces nodosus culture broth. Saquayamycin D exhibits antibacterial activity against various gram-positive bacteria with MIC of 12.5-50 μg/mL. Saquayamycin D inhibits the proliferation of Doxorubicin (HY-15142)-sensitive P388/S and Doxorubicin-resistant P388/ADR with IC₅₀ of 0.15 and 0.15 μg/mL .

HY-116783

GyrB-IN-1	Bacterial DNA/RNA Synthesis	Infection
GyrB-IN-1 is a DNA gyrase (GyrB) inhibitor. GyrB-IN-1 shows an IC₅₀ of 19.1 μM against Mycobacterium smegmatis GyrB ATPase activity and 21.9 μM against Mycobacterium tuberculosis GyrB DNA supercoiling activity. GyrB-IN-1 exerts antimycobacterial activity and has cytotoxicity. GyrB-IN-1 can be used for the research of tuberculosis .

HY-W616426

3,3'-Bi[1H-indole]	Bacterial	Infection Cancer
3,3'-Bi[1H-indole] is a MtbFtsZ inhibitor. 3,3'-Bi[1H-indole] inhibits the GTPase activity of MtbFtsZ. 3,3'-Bi[1H-indole] increases the cell length of Mycobacterium smegmatis and Bacillus subtilis. 3,3'-Bi[1H-indole] can be used in the research of tuberculosis .

HY-E71317

β-Mannosylphosphodecaprenol-mannooligosaccharide 6-mannosyltransferase	Biochemical Assay Reagents	Others
β-Mannosylphosphodecaprenol-mannooligosaccharide 6-mannosyltransferase (EC 2.4.1.199) is involved in the formation of mannooligosaccharides in the membrane of Mycobacterium smegmatis.

HY-155862

Antibacterial agent 152	Bacterial	Infection
Antibacterial agent 152 (Compound 19) is an antibacterial agent. Antibacterial agent 152 displays moderate activity (MIC = 8-16 μg/mL) against Mycobacterium smegmatis MC2-155 .

HY-183687

(rel)-Bedaquinoline impurity 12	Bacterial	Infection
(rel)-Bedaquinoline impurity 12 is a substituted quinoline derivative and anti-mycobacterial inhibitor. (rel)-Bedaquinoline impurity 12 can be used for the research of tuberculosis .

HY-175987

Antimycobacterial agent-12	Bacterial	Infection
Antimycobacterial agent-12 (Compound Ec42), a derivative of Platensimycin (HY-127146), is a dual-functional inhibitor KasA and KasB. Antimycobacterial agent-12 has antibacterial activity with a MICs of 2, 2 and 4 μg/mL against Staphylococcus aureus ATCC 29213, Mycobacterium smegmatis and its Isoniazid (HY-B0329)-resistant strain, respectively. Antimycobacterial agent-12 has a superior antimycobacterial activity in M. smegmatis-infected mouse models. Antimycobacterial agent-12 can be used for tuberculosis research .

HY-120054

Antibacterial agent 322	Bacterial	Infection
Antibacterial agent 322 is an antibacterial agent that inhibits the growth of various bacteria. Antibacterial agent 322 can be used in research on bacterial infections .

HY-181282

MSU-44147	Bacterial	Infection
MSU-44147 is an inhibitor and antimicrobial agent targeting MmpL3 in Mycobacterium abscessus, with low eukaryotic cytotoxicity, a narrow antimicrobial spectrum that is specific only to mycobacteria, and low drug resistance frequency. MSU-44147 reduces trehalose dimycolate levels by inhibiting MmpL3 function, disrupts biofilm formation and reduces the viability of related bacteria, while exerting bactericidal effects on intracellular Mycobacterium abscessus. MSU-44147 exhibits additive or synergistic effects with antibiotics and can be used in research on multidrug-resistant isolates and infections of Mycobacterium abscessus .

HY-D1737

RADA	Bacterial	Infection
RADA is a fluorescent D-amino acid (FDAA) with high photostability and thermostability, which emits yellow-to-orange fluorescence. RADA shows low outer membrane permeability in wild-type Gram-negative Escherichia coli, but it targets penicillin-binding proteins and L,D-transpeptidases, mimics the interaction between acyl acceptors and enzyme intermediates, and integrates into peptidoglycan during biosynthesis. As a peptidoglycan labeling reagent, RADA metabolically integrates into the nascent peptidoglycan of live bacterial cells, labels the peptidoglycan at the poles and lateral walls of mycobacteria, and enables visualization of peptidoglycan synthesis and remodeling processes. RADA serves as a non-specific stain for fixed cells, is non-toxic to bacterial cells, and its red-shifted excitation/emission spectra reduce phototoxicity. RADA also supports virtual pulse-chase labeling experiments and stochastic optical reconstruction microscopy for sub-diffraction-limited imaging of bacterial cell walls .

HY-173528

Antimicrobial agent-40	Bacterial Fungal	Infection Cancer
Antimicrobial agent-40 (Compound 5a) has antimicrobial activity against fungi, Gram-negative and Gram-positive bacteria. Antimicrobial agent-40 has good cytotoxicity against MCF-7 cells (IC₅₀: 33.52 μM) and exhibits anticancer activity .

HY-182711

SCR0911	Bacterial Parasite	Infection
SCR0911 is an inhibitor of mycobacterial cytochrome bcc oxidase and Plasmodium falciparum cytochrome bc1. SCR0911 disrupts oxidative phosphorylation by binding to mycobacterial cytochrome bcc, binds to the Qi site of Plasmodium falciparum cytochrome bc1, inhibits mycobacterial cell growth and ATP synthesis, and exhibits broad-spectrum anti-mycobacterial and anti-malarial activities. SCR0911 can be used in research related to tuberculosis, malaria, and isolated persistent hypermethioninemia (iph) .

HY-183851

KKL-55	Bacterial mRNA	Infection
KKL-55 is a broad-spectrum antibacterial agent that inhibits the trans-translation pathway and the ClpXP protease. KKL-55 suppresses trans-translation of non-stop mRNA, interferes with the binding of EF-Tu to tmRNA, and inhibits the proteolysis of substrates by ClpXP. KKL-55 blocks spore germination of Bacillus anthracis and protects macrophages from damage induced by anthrax toxin. By virtue of its inhibitory effect on ClpXP, KKL-55 synergistically enhances the antibacterial activity of antibiotics against drug-resistant Staphylococcus aureus. KKL-55 can be used in studies related to bacterial infections .

HY-D3391

RMR-Tre	Bacterial	Infection
RMR-Tre is a fluorescent probe targeting the mycobacterial acyltransferase Ag85. Under the catalysis of Ag85, RMR-Tre undergoes 6-position mycoloylation and anchors to the mycobacterial membrane, while achieving fluorescence activation by inhibiting the intramolecular twisted charge transfer state transition. RMR-Tre can distinguish live mycobacteria from dead ones through metabolism-driven labeling, enabling rapid, wash-free, low-background detection of viable bacteria. RMR-Tre reports the drug resistance of Mycobacterium tuberculosis via the trehalose catalytic shift activity readout associated with TreS. In addition, RMR-Tre can be combined with flow cytometry or high-content imaging techniques to visualize and quantitatively analyze the metabolic heterogeneity of Mycobacterium tuberculosis related to persistence and drug resistance. RMR-Tre is widely used in tuberculosis-related research .

製品番号	製品名	Type

HY-D2919

DMN-Tre	蛍光色素
DMN-Tre is a conjugate of a solvatochromic fluorescent dye and trehalose. DMN-Tre takes advantage of the substrate promiscuity of the endogenous antigen 85 protein complex in mycobacteria to be metabolically integrated into the hydrophobic mycobacterial membrane. Once entering this hydrophobic environment, the linked DMN dye fluorescence is "turned on", enabling specific labeling . DMN-Tre can be used to reflect bacterial metabolic activity and support physiological studies of Mycobacterium tuberculosis .

DMN-Tre

蛍光色素

DMN-Tre is a conjugate of a solvatochromic fluorescent dye and trehalose. DMN-Tre takes advantage of the substrate promiscuity of the endogenous antigen 85 protein complex in mycobacteria to be metabolically integrated into the hydrophobic mycobacterial membrane. Once entering this hydrophobic environment, the linked DMN dye fluorescence is "turned on", enabling specific labeling . DMN-Tre can be used to reflect bacterial metabolic activity and support physiological studies of Mycobacterium tuberculosis .

HY-D2729

Cy3-NO2-Tre	蛍光色素
Cy3-NO2-Tre is a nitroreductase-responsive cyanine-based fluorescent probe that specifically labels Mycobacterium tuberculosis (Mtb). Cy3-NO2-tre generated fluorescence after activation by a specific nitroreductase, Rv3368c, which is conserved in the Mycobacteriaceae. Cy3-NO2-tre effectively imaged mycobacteria within infected host cells, tracked the infection process, and visualized Mycobacterium smegmatis being endocytosed by macrophages (Ex/Em= 540-550/575-625 nm) .

Cy3-NO2-Tre

蛍光色素

Cy3-NO2-Tre is a nitroreductase-responsive cyanine-based fluorescent probe that specifically labels Mycobacterium tuberculosis (Mtb). Cy3-NO2-tre generated fluorescence after activation by a specific nitroreductase, Rv3368c, which is conserved in the Mycobacteriaceae. Cy3-NO2-tre effectively imaged mycobacteria within infected host cells, tracked the infection process, and visualized Mycobacterium smegmatis being endocytosed by macrophages (Ex/Em= 540-550/575-625 nm) .

HY-D1737

RADA	蛍光色素
RADA is a fluorescent D-amino acid (FDAA) with high photostability and thermostability, which emits yellow-to-orange fluorescence. RADA shows low outer membrane permeability in wild-type Gram-negative Escherichia coli, but it targets penicillin-binding proteins and L,D-transpeptidases, mimics the interaction between acyl acceptors and enzyme intermediates, and integrates into peptidoglycan during biosynthesis. As a peptidoglycan labeling reagent, RADA metabolically integrates into the nascent peptidoglycan of live bacterial cells, labels the peptidoglycan at the poles and lateral walls of mycobacteria, and enables visualization of peptidoglycan synthesis and remodeling processes. RADA serves as a non-specific stain for fixed cells, is non-toxic to bacterial cells, and its red-shifted excitation/emission spectra reduce phototoxicity. RADA also supports virtual pulse-chase labeling experiments and stochastic optical reconstruction microscopy for sub-diffraction-limited imaging of bacterial cell walls .

RADA

蛍光色素

RADA is a fluorescent D-amino acid (FDAA) with high photostability and thermostability, which emits yellow-to-orange fluorescence. RADA shows low outer membrane permeability in wild-type Gram-negative Escherichia coli, but it targets penicillin-binding proteins and L,D-transpeptidases, mimics the interaction between acyl acceptors and enzyme intermediates, and integrates into peptidoglycan during biosynthesis. As a peptidoglycan labeling reagent, RADA metabolically integrates into the nascent peptidoglycan of live bacterial cells, labels the peptidoglycan at the poles and lateral walls of mycobacteria, and enables visualization of peptidoglycan synthesis and remodeling processes. RADA serves as a non-specific stain for fixed cells, is non-toxic to bacterial cells, and its red-shifted excitation/emission spectra reduce phototoxicity. RADA also supports virtual pulse-chase labeling experiments and stochastic optical reconstruction microscopy for sub-diffraction-limited imaging of bacterial cell walls .

HY-D3391

RMR-Tre	蛍光色素
RMR-Tre is a fluorescent probe targeting the mycobacterial acyltransferase Ag85. Under the catalysis of Ag85, RMR-Tre undergoes 6-position mycoloylation and anchors to the mycobacterial membrane, while achieving fluorescence activation by inhibiting the intramolecular twisted charge transfer state transition. RMR-Tre can distinguish live mycobacteria from dead ones through metabolism-driven labeling, enabling rapid, wash-free, low-background detection of viable bacteria. RMR-Tre reports the drug resistance of Mycobacterium tuberculosis via the trehalose catalytic shift activity readout associated with TreS. In addition, RMR-Tre can be combined with flow cytometry or high-content imaging techniques to visualize and quantitatively analyze the metabolic heterogeneity of Mycobacterium tuberculosis related to persistence and drug resistance. RMR-Tre is widely used in tuberculosis-related research .

RMR-Tre

蛍光色素

RMR-Tre is a fluorescent probe targeting the mycobacterial acyltransferase Ag85. Under the catalysis of Ag85, RMR-Tre undergoes 6-position mycoloylation and anchors to the mycobacterial membrane, while achieving fluorescence activation by inhibiting the intramolecular twisted charge transfer state transition. RMR-Tre can distinguish live mycobacteria from dead ones through metabolism-driven labeling, enabling rapid, wash-free, low-background detection of viable bacteria. RMR-Tre reports the drug resistance of Mycobacterium tuberculosis via the trehalose catalytic shift activity readout associated with TreS. In addition, RMR-Tre can be combined with flow cytometry or high-content imaging techniques to visualize and quantitatively analyze the metabolic heterogeneity of Mycobacterium tuberculosis related to persistence and drug resistance. RMR-Tre is widely used in tuberculosis-related research .

製品番号	製品名	Target	研究分野

HY-125576

Griselimycin	Bacterial	Infection
Griselimycin is a cyclic lipopeptide produced by Streptomyces. Griselimycin specifically binds to the sliding clamp of bacterial DNA polymerase and does not interact with human PCNA. Griselimycin exhibits potent antibacterial activity against Mycobacterium tuberculosis (including drug-resistant strains) and a variety of Gram-negative bacteria .

Carvone	Acourtia cordata (Cerv.) B.L.Turner Structural Classification Ketones, Aldehydes, Acids Umbelliferae Plants Source Classification	Bacterial
Carvone is a ketone monoterpene found in the essential oils from plants of the genus Mentha. Carvone has such effects as anticancer, antimicrobial, antioxidant, anti-inflammatory, antispasmodic, antinociceptive, anticonvulsant .

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