2. Anti-infection
  3. Bacterial Antibiotic
  4. Thiolactomycin

Thiolactomycin is an antibiotic. Thiolactomycin is active against Gram-negative anaerobes. Thiolactomycin also inhibits malaria and trypanosomes. Thiolactomycin is a FabB inhibitor. Thiolactomycin inhibits the synthesis of fatty acids and mycolic acids.

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Thiolactomycin

Thiolactomycin Chemical Structure

CAS No. : 82079-32-1

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Based on 1 publication(s) in Google Scholar

Thiolactomycin Related Antibodies

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Description

Thiolactomycin is an antibiotic. Thiolactomycin is active against Gram-negative anaerobes. Thiolactomycin also inhibits malaria and trypanosomes. Thiolactomycin is a FabB inhibitor. Thiolactomycin inhibits the synthesis of fatty acids and mycolic acids[1][2].

Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
> 380 μM
Compound: 14a-(5R)
Inhibition of FASN in human HepG2 cells
Inhibition of FASN in human HepG2 cells
[PMID: 21726077]
HepG2 IC50
> 80 ng/mL
Compound: 1, TLM
Inhibition of fatty acid synthase type 1 in human HepG2 cells assessed as [1-14C]acetate incorporation into cellular fatty acid
Inhibition of fatty acid synthase type 1 in human HepG2 cells assessed as [1-14C]acetate incorporation into cellular fatty acid
[PMID: 18805004]
HepG2 IC50
> 80 μg/mL
Compound: 1, TLM, thiolactomycin
Inhibition of type1 FAS in HepG2 cells
Inhibition of type1 FAS in HepG2 cells
[PMID: 17507223]
MCF7 IC50
38.4 μg/mL
Compound: {5R}-TLM
Inhibitory concentration against fatty acid synthesis in MCF-7 breast cancer cells
Inhibitory concentration against fatty acid synthesis in MCF-7 breast cancer cells
[PMID: 15715465]
MCF7 IC50
41.8 μg/mL
Compound: Thiolactomycin (TLM)
Inhibitory concentration against fatty acid synthesis in MCF-7 breast cancer cells
Inhibitory concentration against fatty acid synthesis in MCF-7 breast cancer cells
[PMID: 15715465]
MCF7 IC50
> 80 μg/mL
Compound: Thiolactomycin (TLM)
Inhibitory concentration against MCF-7 breast cancer cells in XTT assay (non radioactive assay)
Inhibitory concentration against MCF-7 breast cancer cells in XTT assay (non radioactive assay)
[PMID: 15715465]
MCF7 IC50
> 80 μg/mL
Compound: {5R}-TLM
Inhibitory concentration against MCF-7 breast cancer cells in XTT assay (non radioactive assay)
Inhibitory concentration against MCF-7 breast cancer cells in XTT assay (non radioactive assay)
[PMID: 15715465]
ZR-75-1 IC50
21.1 μg/mL
Compound: {5R}-TLM
Inhibitory concentration against purified human fatty acid synthase activity in ZR-75-1 breast cancer cells
Inhibitory concentration against purified human fatty acid synthase activity in ZR-75-1 breast cancer cells
[PMID: 15715465]
ZR-75-1 IC50
30 μg/mL
Compound: Thiolactomycin (TLM)
Inhibitory concentration against purified human fatty acid synthase activity in ZR-75-1 breast cancer cells
Inhibitory concentration against purified human fatty acid synthase activity in ZR-75-1 breast cancer cells
[PMID: 15715465]
Molecular Weight

210.29

Formula

C11H14O2S
CAS No.
Appearance

Solid

SMILES

C=C/C(C)=C/[C@@]1(C(O)=C(C(S1)=O)C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥97.0%

SDS (393 KB)

COA (251 KB)

Handling Instructions (2659 KB)
References
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Thiolactomycin Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thiolactomycin82079-32-1BacterialAntibioticmalariatrypanosomeGram-negativeanaerobesInhibitorinhibitorinhibit

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