82079-32-1
Chemical Structure
Thiolactomycin
- CAS No.: 82079-32-1
- Formula:C11H14O2S
- Molecular Weight:210.29
IUPAC Name: (R,E)-4-hydroxy-3,5-dimethyl-5-(2-methylbuta-1,3-dien-1-yl)thiophen-2(5H)-one
InChIKey: SYQNUQSGEWNWKV-XUIVZRPNSA-N
SMILES: C=C/C(C)=C/[C@@]1(C(O)=C(C(S1)=O)C)C
Biological Activity: Thiolactomycin is an orally active bacterial type II fatty acid synthase (FAS-II) inhibitor with antibacterial and antimalarial activities. Thiolactomycin specifically targets KasA/KasB in mycobacteria and FabB/FabF in bacteria, thereby inhibiting the biosynthesis of fatty acids and mycolic acids. Thiolactomycin can be used in studies related to tuberculosis, systemic bacterial infections, and experimental pyelonephritis[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Thiolactomycin | 96.65% | Thiolactomycin is an orally active bacterial type II fatty acid synthase (FAS-II) inhibitor with antibacterial and antimalarial activities. Thiolactomycin specifically targets KasA/KasB in mycobacteria and FabB/FabF in bacteria, thereby inhibiting the biosynthesis of fatty acids and mycolic acids. Thiolactomycin can be used in studies related to tuberculosis, systemic bacterial infections, and experimental pyelonephritis. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Douglas JD, et al. Analogues of thiolactomycin: potential drugs with enhanced anti-mycobacterial activity. Microbiology (Reading). 2002;148(Pt 10):3101-3109. [Content Brief]
- [2]. Guo J, et al. Deciphering the Thiolactonization Mechanism in Thiolactomycin Biosynthesis. J Am Chem Soc. 2025;147(26):22368-22386. [Content Brief]
- [3]. Oishi H, et al. Thiolactomycin, a new antibiotic I. Taxonomy of the producing organism, fermentation and biological properties[J]. The Journal of Antibiotics, 1982, 35(4): 391-395.
- [4]. Miyakawa S, et al. Thiolactomycin, a new antibiotic IV. Biological properties and chemotherapeutic activity in mice[J]. The Journal of antibiotics, 1982, 35(4): 411-419.
Keywords
