MSU-44147
MSU-44147 is an inhibitor and antimicrobial agent targeting MmpL3 in Mycobacterium abscessus, with low eukaryotic cytotoxicity, a narrow antimicrobial spectrum that is specific only to mycobacteria, and low drug resistance frequency. MSU-44147 reduces trehalose dimycolate levels by inhibiting MmpL3 function, disrupts biofilm formation and reduces the viability of related bacteria, while exerting bactericidal effects on intracellular Mycobacterium abscessus. MSU-44147 exhibits additive or synergistic effects with antibiotics and can be used in research on multidrug-resistant isolates and infections of Mycobacterium abscessus.
For research use only. We do not sell to patients.
- CAS No.: 3105177-29-2
- Formula: C17H22F3NO
- Molecular Weight:313.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MSU-44147 (80 μM-0.08 nM; 3 d) potently inhibits the growth of Mycobacterium abscessus ATCC 19977 in vitro and exhibits time-dependent bactericidal activity at a concentration of 5× MIC. Meanwhile, it potently inhibits strains of Mycobacterium tuberculosis, Mycobacterium abscessus and Mycobacterium smegmatis, shows no activity against non-mycobacterial species within 80 μM, and displays variable inhibitory activity against clinically isolated multidrug-resistant Mycobacterium abscessus strains[1].
MSU-44147 (0.18 nM-160 μM; 3 d) disrupts mature Mycobacterium abscessus biofilms with an EC50 of 1.96 μM; while also reduces bacterial viability within biofilms, with a corresponding EC50 of 0.18 μM[1].
MSU-44147 (1-160 μM; 3 d) does not kill non-replicating, nutrient-starved Mycobacterium abscessus ATCC 19977 at concentrations up to 160 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mycobacterium tuberculosis strains, Mycobacterium abscessus, and Mycobacterium smegma
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Concentration:80 μM-0.08 nM
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Incubation Time:3 d
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Result:Inhibited the growth of Mycobacterium abscessus ATCC 19977 by an EC50 of 0.46 μM and a MIC of 8.15 μM.
Effectively inhibited Mycobacterium tuberculosis strains (EC50 value of 0.19 to 0.26 μM), Mycobacterium abscessus (EC50 of 0.46 μM), and Mycobacterium smegma (EC50 of 4.16 μM).
Chemical Information
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CAS No. 3105177-29-2
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Molecular Weight 313.36
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Formula C17H22F3NO
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SMILES
CC1(CCCCC1)C(NCCC2=CC=C(C(F)(F)F)C=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MSU-44147 Related Classifications
HY-181282 Related Classifications
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- MSU-44147
- 3105177-29-2
- MSU44147
- MSU 44147
- Bacterial
- mycobacterium abscessus infection
- Mycobacterium abscessus ATCC 19977
- trehalose dimycolate
- Mycobacterium smegmatis
- multidrug-resistant clinical Mycobacterium abscessus isolates
- MmpL3
- murine bone marrow-derived macrophages
- Mycobacterium abscessus
- Mycobacterium tuberculosis
- biofilm formation
- Inhibitor
- inhibitor
- inhibit