2. Anti-infection
  3. Bacterial
  4. MSU-44147

MSU-44147 is an inhibitor and antimicrobial agent targeting MmpL3 in Mycobacterium abscessus, with low eukaryotic cytotoxicity, a narrow antimicrobial spectrum that is specific only to mycobacteria, and low drug resistance frequency. MSU-44147 reduces trehalose dimycolate levels by inhibiting MmpL3 function, disrupts biofilm formation and reduces the viability of related bacteria, while exerting bactericidal effects on intracellular Mycobacterium abscessus. MSU-44147 exhibits additive or synergistic effects with antibiotics and can be used in research on multidrug-resistant isolates and infections of Mycobacterium abscessus.

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MSU-44147

MSU-44147 Chemical Structure

CAS No. : 3105177-29-2

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MSU-44147 Related Antibodies

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Description

MSU-44147 is an inhibitor and antimicrobial agent targeting MmpL3 in Mycobacterium abscessus, with low eukaryotic cytotoxicity, a narrow antimicrobial spectrum that is specific only to mycobacteria, and low drug resistance frequency. MSU-44147 reduces trehalose dimycolate levels by inhibiting MmpL3 function, disrupts biofilm formation and reduces the viability of related bacteria, while exerting bactericidal effects on intracellular Mycobacterium abscessus. MSU-44147 exhibits additive or synergistic effects with antibiotics and can be used in research on multidrug-resistant isolates and infections of Mycobacterium abscessus[1].

In Vitro

MSU-44147 (80 μM-0.08 nM; 3 d) potently inhibits the growth of Mycobacterium abscessus ATCC 19977 in vitro and exhibits time-dependent bactericidal activity at a concentration of 5× MIC. Meanwhile, it potently inhibits strains of Mycobacterium tuberculosis, Mycobacterium abscessus and Mycobacterium smegmatis, shows no activity against non-mycobacterial species within 80 μM, and displays variable inhibitory activity against clinically isolated multidrug-resistant Mycobacterium abscessus strains[1].
MSU-44147 (0.18 nM-160 μM; 3 d) disrupts mature Mycobacterium abscessus biofilms with an EC50 of 1.96 μM; while also reduces bacterial viability within biofilms, with a corresponding EC50 of 0.18 μM[1].
MSU-44147 (1-160 μM; 3 d) does not kill non-replicating, nutrient-starved Mycobacterium abscessus ATCC 19977 at concentrations up to 160 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MSU-44147 Related Antibodies

Cell Viability Assay[1]

Cell Line: Mycobacterium tuberculosis strains, Mycobacterium abscessus, and Mycobacterium smegma
Concentration: 80 μM-0.08 nM
Incubation Time: 3 d
Result: Inhibited the growth of Mycobacterium abscessus ATCC 19977 by an EC50 of 0.46 μM and a MIC of 8.15 μM.
Effectively inhibited Mycobacterium tuberculosis strains (EC50 value of 0.19 to 0.26 μM), Mycobacterium abscessus (EC50 of 0.46 μM), and Mycobacterium smegma (EC50 of 4.16 μM).
Molecular Weight

313.36

Formula

C17H22F3NO
CAS No.
SMILES

CC1(CCCCC1)C(NCCC2=CC=C(C(F)(F)F)C=C2)=O
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References
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MSU-44147 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MSU-441473105177-29-2MSU44147MSU 44147Bacterialmycobacterium abscessus infectionMycobacterium abscessus ATCC 19977trehalose dimycolateMycobacterium smegmatismultidrug-resistant clinical Mycobacterium abscessus isolatesMmpL3murine bone marrow-derived macrophagesMycobacterium abscessusMycobacterium tuberculosisbiofilm formationInhibitorinhibitorinhibit

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