SCR0911

SCR0911 inhibits the growth of M. smegmatis mc²155 (MIC₅₀ = 272 μM) and M. bovis BCG (MIC₅₀ = 107 μM), but fails to inhibit the growth of the M. smegmatis Δbcc mutant strain, indicating that its growth inhibitory activity depends on a functionally intact cytochrome bcc complex^[1].
SCR0911 (24 h) inhibits intracellular ATP synthesis of M. bovis BCG, with an IC₅₀ of 50 μM^[1].
SCR0911 (30 min) inhibits ATP synthesis in M. smegmatis IMVs (IC₅₀ = 7.6 μM) and M. bovis BCG IMVs (IC₅₀ = 6.9 μM) when NADH serves as the electron donor^[1].
SCR0911 (30 min) inhibits ATP synthesis in M. smegmatis PMVs, with comparable potency when NADH (IC₅₀ = 3.8 μM) or succinate (IC₅₀ = 3.4 μM) serves as the electron donor^[1].
SCR0911 (680 μM) completely inhibits oxygen consumption in M. smegmatis mc²155^[1].
SCR0911 (10 mM) restores the SAMe-producing activity of purified human MAT-1 MAT-1^R264H mutant protein to the wild-type level^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.