2. Anti-infection
  3. Bacterial Parasite
  4. SCR0911

SCR0911 is an inhibitor of mycobacterial cytochrome bcc oxidase and Plasmodium falciparum cytochrome bc1. SCR0911 disrupts oxidative phosphorylation by binding to mycobacterial cytochrome bcc, binds to the Qi site of Plasmodium falciparum cytochrome bc1, inhibits mycobacterial cell growth and ATP synthesis, and exhibits broad-spectrum anti-mycobacterial and anti-malarial activities. SCR0911 can be used in research related to tuberculosis, malaria, and isolated persistent hypermethioninemia (iph).

For research use only. We do not sell to patients.

SCR0911

SCR0911 Chemical Structure

CAS No. : 1379615-30-1

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SCR0911 Related Antibodies

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Description

SCR0911 is an inhibitor of mycobacterial cytochrome bcc oxidase and Plasmodium falciparum cytochrome bc1. SCR0911 disrupts oxidative phosphorylation by binding to mycobacterial cytochrome bcc, binds to the Qi site of Plasmodium falciparum cytochrome bc1, inhibits mycobacterial cell growth and ATP synthesis, and exhibits broad-spectrum anti-mycobacterial and anti-malarial activities. SCR0911 can be used in research related to tuberculosis, malaria, and isolated persistent hypermethioninemia (iph)[1][2].

In Vitro

SCR0911 inhibits the growth of M. smegmatis mc2155 (MIC50 = 272 μM) and M. bovis BCG (MIC50 = 107 μM), but fails to inhibit the growth of the M. smegmatis Δbcc mutant strain, indicating that its growth inhibitory activity depends on a functionally intact cytochrome bcc complex[1].
SCR0911 (24 h) inhibits intracellular ATP synthesis of M. bovis BCG, with an IC50 of 50 μM[1].
SCR0911 (30 min) inhibits ATP synthesis in M. smegmatis IMVs (IC50 = 7.6 μM) and M. bovis BCG IMVs (IC50 = 6.9 μM) when NADH serves as the electron donor[1].
SCR0911 (30 min) inhibits ATP synthesis in M. smegmatis PMVs, with comparable potency when NADH (IC50 = 3.8 μM) or succinate (IC50 = 3.4 μM) serves as the electron donor[1].
SCR0911 (680 μM) completely inhibits oxygen consumption in M. smegmatis mc2155[1].
SCR0911 (10 mM) restores the SAMe-producing activity of purified human MAT-1 MAT-1R264H mutant protein to the wild-type level[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SCR0911 Related Antibodies
Molecular Weight

426.39

Formula

C23H17F3N2O3
CAS No.
SMILES

O=C1C2=CC=C(C=C2NC(C3=CN=CC(C4=CC=C(C=C4)OC(F)(F)F)=C3)=C1C)OC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SCR0911 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SCR09111379615-30-1SCR 0911SCR-0911BacterialParasitetuberculosisoxidative phosphorylationPlasmodium falciparum cytochrome bc1isolated persistent hypermethioninemiamycobacterial cytochrome bcc oxidaseQi siteMycobacterium smegmatisMycobacterium bovis BCGSAMeR264H MAT-1 mutantInhibitorinhibitorinhibit

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