1379615-30-1
Chemical Structure
SCR0911
- CAS No.: 1379615-30-1
- Formula:C23H17F3N2O3
- Molecular Weight:426.39
InChIKey: ZZCQNODHORIHJA-UHFFFAOYSA-N
SMILES: O=C1C2=CC=C(C=C2NC(C3=CN=CC(C4=CC=C(C=C4)OC(F)(F)F)=C3)=C1C)OC
Biological Activity: SCR0911 is an inhibitor of mycobacterial cytochrome bcc oxidase and Plasmodium falciparum cytochrome bc1. SCR0911 disrupts oxidative phosphorylation by binding to mycobacterial cytochrome bcc, binds to the Qi site of Plasmodium falciparum cytochrome bc1, inhibits mycobacterial cell growth and ATP synthesis, and exhibits broad-spectrum anti-mycobacterial and anti-malarial activities. SCR0911 can be used in research related to tuberculosis, malaria, and isolated persistent hypermethioninemia (iph)[1][2].
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SCR0911 | SCR0911 is an inhibitor of mycobacterial cytochrome bcc oxidase and Plasmodium falciparum cytochrome bc1. SCR0911 disrupts oxidative phosphorylation by binding to mycobacterial cytochrome bcc, binds to the Qi site of Plasmodium falciparum cytochrome bc1, inhibits mycobacterial cell growth and ATP synthesis, and exhibits broad-spectrum anti-mycobacterial and anti-malarial activities. SCR0911 can be used in research related to tuberculosis, malaria, and isolated persistent hypermethioninemia (iph). | |||||||||||||||||||||
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- [1]. Chong SMS, et al. Antituberculosis Activity of the Antimalaria Cytochrome bcc Oxidase Inhibitor SCR0911. ACS Infect Dis. 2020;6(4):725-737. [Content Brief]
- [2]. Panmanee J, et al. Structural basis of the dominant inheritance of hypermethioninemia associated with the Arg264His mutation in the MAT1A gene. Acta Crystallogr D Struct Biol. 2020;76(Pt 6):594-607. [Content Brief]
Keywords
