country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-116783

Copy Link Print Information

GyrB-IN-1

GyrB-IN-1 is a DNA gyrase (GyrB) inhibitor. GyrB-IN-1 shows an IC₅₀ of 19.1 μM against Mycobacterium smegmatis GyrB ATPase activity and 21.9 μM against Mycobacterium tuberculosis GyrB DNA supercoiling activity. GyrB-IN-1 exerts antimycobacterial activity and has cytotoxicity. GyrB-IN-1 can be used for the research of tuberculosis.

For research use only. We do not sell to patients.

CAS No.: 1870007-38-7
Formula: C₂₁H₁₂ClN₃O₂S
Molecular Weight:405.86

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GyrB-IN-1 Chemical Structure

CAS No.: 1870007-38-7

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

GyrB-IN-1 (Compound 13) inhibits M. smegmatis GyrB ATPase activity with an IC₅₀ of 19.1 ± 1.8 μM^[1].
GyrB-IN-1 inhibits M. tuberculosis GyrB-mediated DNA supercoiling activity with an IC₅₀ of 21.9 ± 4.2 μM^[1].
GyrB-IN-1 inhibits the growth of M. tuberculosis H₃₇Rv strain with an MIC of 30.8 μM^[1].
GyrB-IN-1 (100 μM) induces 22.35% cytotoxicity in RAW 264.7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1870007-38-7
Molecular Weight 405.86
Formula C₂₁H₁₂ClN₃O₂S
SMILES

O=C(C1=CC=C(C=C1)C2=CC=C(S2)/C=C(C#N)/C3=NC4=CC(Cl)=CC=C4N3)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jeankumar VU, et al. Structure-Guided Discovery of Antitubercular Agents That Target the Gyrase ATPase Domain. ChemMedChem. 2016;11(5):539-548. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

GyrB-IN-1

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

GyrB-IN-1 Related Classifications

HY-116783 Related Classifications