1870007-38-7
Chemical Structure
GyrB-IN-1
- CAS No.: 1870007-38-7
- Formula:C21H12ClN3O2S
- Molecular Weight:405.86
IUPAC Name: (E)-4-(5-(2-(5-chloro-1H-benzo[d]imidazol-2-yl)-2-cyanovinyl)thiophen-2-yl)benzoic acid
InChIKey: KCRGBCOERUHZLY-NTEUORMPSA-N
SMILES: O=C(C1=CC=C(C=C1)C2=CC=C(S2)/C=C(C#N)/C3=NC4=CC(Cl)=CC=C4N3)O
Biological Activity: GyrB-IN-1 is a DNA gyrase (GyrB) inhibitor. GyrB-IN-1 shows an IC50 of 19.1 μM against Mycobacterium smegmatis GyrB ATPase activity and 21.9 μM against Mycobacterium tuberculosis GyrB DNA supercoiling activity. GyrB-IN-1 exerts antimycobacterial activity and has cytotoxicity. GyrB-IN-1 can be used for the research of tuberculosis[1].
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GyrB-IN-1 | GyrB-IN-1 is a DNA gyrase (GyrB) inhibitor. GyrB-IN-1 shows an IC50 of 19.1 μM against Mycobacterium smegmatis GyrB ATPase activity and 21.9 μM against Mycobacterium tuberculosis GyrB DNA supercoiling activity. GyrB-IN-1 exerts antimycobacterial activity and has cytotoxicity. GyrB-IN-1 can be used for the research of tuberculosis. | |||||||||||||||||||||
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Keywords
