FtsZ-IN-9
FtsZ-IN-9 (compound 11) is an antimicrobial agent. FtsZ-IN-9 inhibits the assembly of Mycobacterium smegmatis FtsZ (MsFtsZ)[1].
For research use only. We do not sell to patients.
- CAS No.: 1273524-44-9
- Formula: C26H27NO4
- Molecular Weight:417.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | CC50 |
13.5 μM
Compound: 11
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Cytotoxicity against human CEM-GFP cells after 48 hrs by MTT assay
Cytotoxicity against human CEM-GFP cells after 48 hrs by MTT assay
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[PMID: 21227704] |
| CCRF-CEM | EC50 |
4.2 μM
Compound: 11
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Antiviral activity against HIV1 NL4.3 infected in human CEM-GFP T cells assessed as inhibition of p24 antigen production after 7 days by ELISA
Antiviral activity against HIV1 NL4.3 infected in human CEM-GFP T cells assessed as inhibition of p24 antigen production after 7 days by ELISA
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[PMID: 21227704] |
Chemical Information
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CAS No. 1273524-44-9
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Molecular Weight 417.50
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Formula C26H27NO4
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SMILES
OC1=C(O)C=CC(/C=C/C(C2=CC=C(NC(C34C[C@H]5C[C@H](C[C@H](C5)C4)C3)=O)C=C2)=O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FtsZ-IN-9 Related Classifications
HY-161148 Related Classifications
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