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Phosphatase-IN-1

" in MedChemExpress (MCE) Product Catalog:

49

Inhibitors & Agonists

1

Screening Libraries

2

Fluorescent Dyes

1

Biochemical Assay Reagents

6

Peptides

4

Natural
Products

1

Isotope-Labeled Compounds

1

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-100463
    TPI-1
    Maximum Cited Publications
    20 Publications Verification

    		 SHP1 Phosphatase Inflammation/Immunology Cancer
    TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor; inhibits recombinant SHP-1 with an IC50 of 40 nM.
    TPI-1
  • HY-109041
    Razuprotafib
    4 Publications Verification

    AKB-9778

    		 Phosphatase Tie Inflammation/Immunology
    Razuprotafib (AKB-9778) is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC50of 17 pM. Razuprotafib promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib inhibits the structurally related phosphatase PTP1B with an IC50 of 780 nM. Razuprotafib shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPη (IC50=36 pM) and HPTPγ (100 pM) [1].
    Razuprotafib
  • HY-108547
    Alexidine dihydrochloride
    5 Publications Verification

    		 Fungal Apoptosis Infection Cancer
    Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens [1].
    Alexidine dihydrochloride
  • HY-108599
    DCP-LA
    5+ Cited Publications

    FR236924

    		 PKC CaMK Phosphatase Apoptosis Neurological Disease
    DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε. DCP-LA activates Ca( 2+)/calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis [1] .
    DCP-LA
  • HY-108543
    NSC 95397
    5+ Cited Publications

    		 Phosphatase Apoptosis Cancer
    NSC 95397 is a potent, selective Cdc25 dual specificity phosphatase inhibitor (Ki=32 nM (Cdc25A), 96 nM (Cdc25B), 40 nM (Cdc25C); IC50=22.3 nM (human Cdc25A), 56.9 nM (human Cdc25C), 125 nM (Cdc25B)) [1]. NSC 95397 inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) and suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway .
    NSC 95397
  • HY-15909
    BCIP

    BCIP p-toluidINe salt; X-phosphate p-toluidINe salt

    		 Fluorescent Dye Others
    BCIP(BCIP p-toluidine salt; X-phosphate p-toluidine salt) is an artificial chromogenic substrate used for the sensitive colorimetric detection of alkaline phosphatase activity .
    BCIP
  • HY-W007599
    (S)-2,6-Bis((tert-butoxycarbonyl)amino)hexanoic acid

    		Drug Derivative Cancer
    (S)-2,6-Bis((tert-butoxycarbonyl)amino)hexanoic acid is a polypeptide derivative, can be used to synthesis multifunctional amphiphilic peptide dendrimer for non-viral gene delivery in cancer research. (S)-2,6-Bis((tert-butoxycarbonyl)amino)hexanoic acid can be used in the preparation of organic substances that enhance the luminescence intensity of alkaline phosphatase substrates .
    (S)-2,6-Bis((tert-butoxycarbonyl)amino)hexanoic acid
  • HY-109011
    Rosiptor
    3 Publications Verification

    AQX-1125

    		 Phosphatase Cancer
    Rosiptor (AQX-1125) is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. Rosiptor (AQX-1125) inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro [1] .
    Rosiptor
  • HY-121515
    DPM-1001

    		Phosphatase Metabolic Disease
    DPM-1001 is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM. DPM-1001 is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 has anti-diabetic property [1].
    DPM-1001
  • HY-123960
    Raphin1
    3 Publications Verification

    		 Phosphatase Neurological Disease
    Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 binds strongly to the R15B-PP1c holophosphatase (Kd=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease [1].
    Raphin1
  • HY-12833
    AMZ30
    1 Publications Verification

    		 Phosphatase Akt ERK Others
    AMZ30 is selective protein phosphatase methylesterase-1(PME-1) inhibitor with IC50s of 600 nM and 3.5 µM in human cell lysates and in HEK 293T cells, respectively. AMZ30 shows >100-fold selectivity relative to other serine hydrolases. AMZ30 reduces the demethylated form of PP2A in living cells. AMZ30 attenuates muscle cell differentiation. AMZ30 increases the resistance of U87MG and U251MG glioblastoma cells to t-BHP-induced oxidative stress. AMZ30can be used for the study of glioblastoma [1] .
    AMZ30
  • HY-15756
    PTP1B-IN-4
    1 Publications Verification

    		 Phosphatase Metabolic Disease
    PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC50 of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes [1] .
    PTP1B-IN-4
  • HY-130514
    SMAPP1

    		HIV CDK Infection
    SMAPP1 is an activator of protein phosphatase-1 (PP1). SMAPP1 increases phosphorylation of CDK9’s Ser90 and Thr186 residues, but not Ser175. SMAPP1 induces HIV-1 replication, upregulates HIV-1 transcription that led to the reactivation of latent HIV-1 provirus [1].
    SMAPP1
  • HY-123960A
    Raphin1 acetate
    3 Publications Verification

    		 Phosphatase Neurological Disease
    Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase (Kd=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 acetate crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease [1].
    Raphin1 acetate
  • HY-P2040
    Nodularin

    		Phosphatase Cancer
    Nodularin is a potent hepatotoxin, tumor promoter, and protein phosphatase inhibitor .
    Nodularin
  • HY-112832
    Lumigen APS-5

    		Phosphatase Infection
    Lumigen APS-5 is a substrate of alkaline phosphatase (ALP). Lumigen APS-5 can be used to assess the activity of alkaline phosphatase (ALP) .
    Lumigen APS-5
  • HY-123846
    MLS-0437605
    1 Publications Verification

    		 Phosphatase Cardiovascular Disease
    MLS-0437605 is a selective dual-specificity phosphatase 3 (DUSP3) inhibitor with an IC50 of 3.7 μM. MLS-0437605 is more selective for DUSP3 than DUSP22 and other protein tyrosine phosphatases (PTPs) .
    MLS-0437605
  • HY-149492
    Phosphatase-IN-1

    		Phosphatase Fungal Infection
    Phosphatase-IN-1 (compound II-8), a propranolol (HY-B0573B) derivative, is a phosphatidate phosphatase (Pah) inhibitor. Phosphatase-IN-1 can binds to MoPah1, with an affinity constant of 19.8 μM. Phosphatase-IN-1 inhibits growth of plant pathogens and shows anti-fungal ability. Phosphatase-IN-1 is not toxic to rice seedlings and wheat heads [1].
    Phosphatase-IN-1
  • HY-124644
    1E7-03

    		HIV Phosphatase Infection
    1E7-03, a low MW tetrahydroquinoline derivative targeting protein phosphatase-1, can inhibit HIV-1 transcription [1].
    1E7-03
  • HY-121515A
    DPM-1001 trihydrochloride

    		Phosphatase Metabolic Disease
    DPM-1001 trihydrochloride is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM. DPM-1001 trihydrochloride is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 trihydrochloride has anti-diabetic property [1].
    DPM-1001 trihydrochloride
  • HY-133095
    BML-260

    		STAT PPAR Inflammation/Immunology
    BML-260 is a potent inhibitor of dual-specific phosphatases JSP-1 and DUSP22. BML-260 can activate UCP1 and thermogenesis in adipocytes in a JSP-1-independent manner. The effect of BML-260 on adipocytes is partially achieved through the activation of CREB, STAT3, and PPAR signaling pathways. BML-260 can be used in the research of inflammatory and proliferative disorders associated with JNK signaling dysfunction as well as obesity [1] .
    BML-260
  • HY-136595
    3,5-Difluoro-L-tyrosine

    		Phosphatase Others
    3,5-Difluoro-L-tyrosine is a functional, tyrosinase-resistant mimetic of tyrosine. 3,5-Difluoro-L-tyrosine can be used to analyze the substrate specificity of protein tyrosine phosphatases (PTPs) .
    3,5-Difluoro-L-tyrosine
  • HY-P0320
    EGF Receptor Substrate 2 (Phospho-Tyr5)

    		Phosphatase Others
    EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity .
    EGF Receptor Substrate 2 (Phospho-Tyr5)
  • HY-N2111
    Momordicoside A

    		Phosphatase Metabolic Disease
    Momordicoside A is isolated from Momordica charantia L. Momordicoside A has the inhibitory effect on protein tyrosine phosphatase (PTP1B) [1].
    Momordicoside A
  • HY-W040295
    Fast Red ITR

    		Phosphatase Others
    Fast Red ITR is a nonlinear optical material [1]. Fast Red ITR can be used in alkaline phosphatase histochemistry .
    Fast Red ITR
  • HY-130913
    5-FAM-Alkyne

    		Phosphatase Others
    5-FAM-Alkyne is a high selective and sensitive fluorescent biosensor for alkaline phosphatase (ALP) . 5-FAM-Alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    5-FAM-Alkyne
  • HY-113821
    1-Naphthyl phosphate potassium salt

    		Phosphatase Others
    1-Naphthyl phosphate potassium salt is a non-specific phosphatase inhibitor. 1-Naphthyl phosphate potassium salt decreases the splice-correcting effect [1].
    1-Naphthyl phosphate potassium salt
  • HY-B1474
    Alexidine

    		Fungal Infection Cancer
    Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis [1].
    Alexidine
  • HY-156970
    Phosphatase Binder-1

    		Phosphatase Cancer
    Phosphatase Binder-1 (comppund i-196) provides bifunctional compounds that efficiently dephosphorylate certain phospho-activated target proteins. Phosphatase Binder-1 plays an important role in cancer [1].
    Phosphatase Binder-1
  • HY-P1984
    Alphostatin

    		Phosphatase Others
    Alphostatin is a bovine liver alkaline phosphatase inhibitor .
    Alphostatin
  • HY-115759
    N-Octylmaleimide

    		Phosphatase Metabolic Disease
    N-Octylmaleimide is an alkylmaleimide, which can inhibit rat liver glucose 6-phosphatase .
    N-Octylmaleimide
  • HY-W554649
    p-Aminophenyl phosphate

    		Phosphatase Others
    p-Aminophenyl phosphate is an alkaline phosphatase substrate, and can be used for the electrochemical measurement of alkaline phosphatase activity .
    p-Aminophenyl phosphate
  • HY-127178
    ML120 analog 1

    		Phosphatase Cancer
    ML120 analog 1 (compound 1) is a competitive inhibitor with a Ki of 0.69 μM for Hematopoietic protein tyrosine phosphatase (HePTP) .
    ML120 analog 1
  • HY-155037
    VE-PTP-IN-1

    		Phosphatase Cancer
    VE-PTP-IN-1 (compound 2) is a weakly acidic and selective inhibitor of vascular endothelial protein tyrosine phosphatase (VE-PTP).VE-PTP-IN-1 is assocaited with vascular homeostasis and angiogenesis.
    VE-PTP-IN-1
  • HY-149097
    ITH12711

    		Phosphatase Neurological Disease
    ITH12711 is a PP2A ligand. ITH12711 is able to cross the blood-brain barrier (BBB). ITH12711 exerts neuroprotection via restoration of PP2A-phosphatase activity .
    ITH12711
  • HY-109011A
    Rosiptor acetate

    AQX-1125 acetate

    		 Phosphatase Cancer
    Rosiptor (AQX-1125) acetate is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. Rosiptor acetate (AQX-1125) inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro [1] .
    Rosiptor acetate
  • HY-P0320B
    EGF Receptor Substrate 2 (Phospho-Tyr5) acetate

    		Phosphatase Biochemical Assay Reagents Others
    EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity .
    EGF Receptor Substrate 2 (Phospho-Tyr5) acetate
  • HY-P0320A
    EGF Receptor Substrate 2 (Phospho-Tyr5) TFA

    		Phosphatase Biochemical Assay Reagents Others
    EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity .
    EGF Receptor Substrate 2 (Phospho-Tyr5) TFA
  • HY-108547R
    Alexidine dihydrochloride (Standard)

    		Fungal Apoptosis Infection Cancer
    Alexidine (dihydrochloride) (Standard) is the analytical standard of Alexidine (dihydrochloride). This product is intended for research and analytical applications. Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens [1].
    Alexidine dihydrochloride (Standard)
  • HY-N12613
    Sydowimide A

    		SHP1 Phosphatase Inflammation/Immunology
    Sydowimide A is a potent inhibitor of Src homology region 2 domain-containing phosphatase-1 (SHP1), T-cell protein tyrosine phosphatase (TCPTP) and leukocyte common antigen (CD45), with IC50 values of 1.5, 2.4 and 18.83 μM, respectively [1].
    Sydowimide A
  • HY-N11441
    cis-Ferulic acid 4-O-β-D-glucopyranoside

    		Phosphatase Metabolic Disease
    cis-Ferulic acid 4-O-β-D-glucopyranoside (compound 7) is a phenolic glycosid, which can be isolated from Nitraria sibirica.. cis-Ferulic acid 4-O-β-D-glucopyranoside exhibits antioxidant activity and potent inhibitory effect on Phosphatase PTP1B [1].
    cis-Ferulic acid 4-O-β-D-glucopyranoside
  • HY-15321A
    Etoricoxib hydrochloride

    MK-0663 hydrochloride; L-791456 hydrochloride

    		 COX Inflammation/Immunology
    Etoricoxib hydrochloride (MK-0663 hydrochloride) is a synthetic nonsteroidal anti-inflammatory drug with cyclooxygenase-2 inhibitory activity. Etoricoxib hydrochloride can inhibit the conversion of arachidonic acid to prostaglandins, thereby reducing inflammation and pain. Etoricoxib hydrochloride is used to inhibit osteoarthritis and has anti-inflammatory and bone remodeling effects. The formulation of etoricoxib hydrochloride is prepared by emulsion solvent evaporation technology and exhibits good cell compatibility and enhanced alkaline phosphatase activity .
    Etoricoxib hydrochloride
  • HY-162480
    PTP1B-IN-27

    		Glycosidase Phosphatase Endocrinology
    PTP1B-IN-27 (Compound 7i) is an inhibitor of protein tyrosine phosphatase 1-B (PTP‐1B)(IC50=8.2 µM). PTP1B-IN-27 also inhibits α-Glucosidase (IC50=120 µM) and shows competitive inhibition (Ki=118 µM) [1].
    PTP1B-IN-27
  • HY-D2204
    SHP1-IN-1

    		Phosphatase SHP1 Fluorescent Dye Cancer
    SHP1-IN-1 (compound 5p) is a fluorescent probe for the protein tyrosine phosphatase SHP1 containing the Src homology 2 domain. SHP1-IN-1 has SHP1 inhibitory activity, selectivity for Fe 3+ ions and good fluorescence properties. SHP1-IN-1 exhibits aggregation post-quenching (ACQ) effect, good interference immunity and low detection limit (5.55 μM) [1].
    SHP1-IN-1
  • HY-108599R
    DCP-LA (Standard)

    FR236924 (Standard)

    		 Reference Standards PKC CaMK Phosphatase Apoptosis Neurological Disease
    DCP-LA (Standard) is the analytical standard of DCP-LA. This product is intended for research and analytical applications. DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε. DCP-LA activates Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis[1][2][3].
    DCP-LA (Standard)
  • HY-B1474S1
    Alexidine-d10

    		Isotope-Labeled Compounds Fungal Infection Cancer
    Alexidine-d10 is the deuterium labeled Alexidine (HY-B1474). Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis [1].
    Alexidine-d10
  • HY-109041A
    Razuprotafib sodium

    AKB-9778 sodium

    		 Phosphatase Tie Inflammation/Immunology
    Razuprotafib (AKB-9778) sodium is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC50of 17 pM. Razuprotafib sodium promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib sodium inhibits the structurally related phosphatase PTP1B with an IC50 of 780 nM. Razuprotafib sodium shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPη (IC50=36 pM) and HPTPγ (100 pM) [1].
    Razuprotafib sodium
  • HY-108543R
    NSC 95397 (Standard)

    		Reference Standards Phosphatase Apoptosis Cancer
    NSC 95397 (Standard) is the analytical standard of NSC 95397 (HY-108543). This product is intended for research and analytical applications. NSC 95397 is a potent, selective Cdc25 dual specificity phosphatase inhibitor (Ki=32 nM (Cdc25A), 96 nM (Cdc25B), 40 nM (Cdc25C); IC50=22.3 nM (human Cdc25A), 56.9 nM (human Cdc25C), 125 nM (Cdc25B)) [1]. NSC 95397 inhibits mitogen-activated protein Kinase phosphatase-1 (MKP-1) and suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway .
    NSC 95397 (Standard)
  • HY-109041R
    Razuprotafib (Standard)

    AKB-9778 (Standard)

    		 Reference Standards Phosphatase Tie Inflammation/Immunology
    Razuprotafib (Standard) is the analytical standard of Razuprotafib (HY-109041). This product is intended for research and analytical applications. Razuprotafib (AKB-9778) is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC50of 17 pM. Razuprotafib promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib inhibits the structurally related phosphatase PTP1B with an IC50 of 780 nM. Razuprotafib shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPη (IC50=36 pM) and HPTPγ (100 pM) [1].
    Razuprotafib (Standard)

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