2. Metabolic Enzyme/Protease Anti-infection
  3. Phosphatase Fungal
  4. Phosphatase-IN-1

Phosphatase-IN-1 (compound II-8), a propranolol (HY-B0573B) derivative, is a phosphatidate phosphatase (Pah) inhibitor. Phosphatase-IN-1 can binds to MoPah1, with an affinity constant of 19.8 μM. Phosphatase-IN-1 inhibits growth of plant pathogens and shows anti-fungal ability. Phosphatase-IN-1 is not toxic to rice seedlings and wheat heads.

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Phosphatase-IN-1

Phosphatase-IN-1 Chemical Structure

CAS No. : 2889356-55-0

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Based on 1 publication(s) in Google Scholar

Phosphatase-IN-1 Related Antibodies

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Description

Phosphatase-IN-1 (compound II-8), a propranolol (HY-B0573B) derivative, is a phosphatidate phosphatase (Pah) inhibitor. Phosphatase-IN-1 can binds to MoPah1, with an affinity constant of 19.8 μM. Phosphatase-IN-1 inhibits growth of plant pathogens and shows anti-fungal ability. Phosphatase-IN-1 is not toxic to rice seedlings and wheat heads[1].

In Vitro

Phosphatase-IN-1 (compound II-8) effectively inhibits vegetative growth of eight plant pathogens at 223 60 µM[1].
Phosphatase-IN-1 shows attenuated inhibition on the Mopah1 mutant in comparison to the WT strain[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Phosphatase-IN-1 Related Antibodies
Molecular Weight

344.21

Formula

C16H16Cl2FNO2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

FC1=CC=C(CNCC(COC2=CC=C(C=C2Cl)Cl)O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 35 mg/mL (101.68 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9052 mL 14.5260 mL 29.0520 mL
5 mM 0.5810 mL 2.9052 mL 5.8104 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9052 mL 14.5260 mL 29.0520 mL 72.6301 mL
5 mM 0.5810 mL 2.9052 mL 5.8104 mL 14.5260 mL
10 mM 0.2905 mL 1.4526 mL 2.9052 mL 7.2630 mL
15 mM 0.1937 mL 0.9684 mL 1.9368 mL 4.8420 mL
20 mM 0.1453 mL 0.7263 mL 1.4526 mL 3.6315 mL
25 mM 0.1162 mL 0.5810 mL 1.1621 mL 2.9052 mL
30 mM 0.0968 mL 0.4842 mL 0.9684 mL 2.4210 mL
40 mM 0.0726 mL 0.3632 mL 0.7263 mL 1.8158 mL
50 mM 0.0581 mL 0.2905 mL 0.5810 mL 1.4526 mL
60 mM 0.0484 mL 0.2421 mL 0.4842 mL 1.2105 mL
80 mM 0.0363 mL 0.1816 mL 0.3632 mL 0.9079 mL
100 mM 0.0291 mL 0.1453 mL 0.2905 mL 0.7263 mL
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Phosphatase-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phosphatase-IN-12889356-55-0PhosphataseFungalInhibitorinhibitorinhibit

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