2. Alexidine

Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Alexidine dihydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Alexidine Chemical Structure

Alexidine Chemical Structure

CAS No. : 22573-93-9

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Alexidine Related Antibodies

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Description

Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis[1].

In Vitro

Alexidine (10 µM, 24 hours) treatment can decimate the biofilm community[1].
Alexidine (0-60 μg/ml, 24 hours) treatment can kill HUVECs and lung A549 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Alexidine Related Antibodies

Cell Viability Assay[1]

Cell Line: C. albicans, C. auris, A. fumigatus
Concentration: 10 µM
Incubation Time: 24 hours
Result: Could significantly kill 80% of mature biofilm community.

Cell Viability Assay[1]

Cell Line: HUVECs, lung A549 cells
Concentration: 0-60 μg/ml
Incubation Time: 24 hours
Result: resulted in 50% killing of HUVECs and lung A549 cells ( CC50 > 7.37 μg/ml ).
In Vivo

Alexidine (Jugular vein-catheterized; 48 hours; 3 µg/ml; once) can decimate preformed biofilms growing in the jugular vein catheters of mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-week-old C57BL/6 male mice
Dosage: 3 µg/ml
Administration: Jugular vein-catheterized, 48 hours, 3 µg/ml, once
Result: Inhibited 67% of fungal biofilm growth and viability, compared to the control untreated biofilms.
Molecular Weight

508.79

Formula

C26H56N10
CAS No.
SMILES

N=C(NCC(CC)CCCC)NC(NCCCCCCNC(NC(NCC(CC)CCCC)=N)=N)=N
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alexidine22573-93-9Inhibitorinhibitorinhibit

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