PTP1B-IN-4
Based on 1 publication(s) in Google Scholar
PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC50 of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes.
For research use only. We do not sell to patients.
- Purity: 99.55%
- CAS No.: 765317-72-4
- Formula: C26H19Br2N3O7S3
- Molecular Weight:741.45
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Anti-diabetic Compound Library
HY-L040
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Phosphatase Inhibitor Library
HY-L081
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Anti-Obesity Compound Library
HY-L087
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Heterocyclic Compound Library
HY-L138
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Metabolic Enzyme Compound Library
HY-L146
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Bioactive Compound Library Max
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Publications Citing Use of MedChemExpress (MCE) PTP1B-IN-4
More
Biological Activity
IC50: 8 μM (PTP1B)[1]
PTP1B-IN-4 (250 μM; 1 hour) stimulates insulin receptor (IR) phosphorylation in CHO cells overexpressing human IR[1].
PTP1B-IN-4 also induces phosphorylation of IRS-1 and Akt, proteins downstream of the insulin receptor[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CHO cells
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Concentration:250 µM
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Incubation Time:1 hour
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Result:Stimulated insulin receptor phosphorylation.
Chemical Information
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CAS No. 765317-72-4
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Appearance Solid
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Molecular Weight 741.45
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Formula C26H19Br2N3O7S3
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Color White to off-white
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SMILES
O=S(C1=CC=C2C(C(C3=CC(Br)=C(O)C(Br)=C3)=O)=C(CC)OC2=C1)(NC4=CC=C(S(=O)(NC5=NC=CS5)=O)C=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Rep
Context-dependent inhibitory roles of RhoA in 3D invasive cell migration within the extracellular matrix. [Abstract]2025 Dec 6;44(12):116649. PMID: 41359424
Solvent & Solubility
DMSO : 100 mg/mL (134.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3487 mL | 6.7435 mL | 13.4871 mL | 33.7177 mL |
| 5 mM | 0.2697 mL | 1.3487 mL | 2.6974 mL | 6.7435 mL | |
| 10 mM | 0.1349 mL | 0.6744 mL | 1.3487 mL | 3.3718 mL | |
| 15 mM | 0.0899 mL | 0.4496 mL | 0.8991 mL | 2.2478 mL | |
| 20 mM | 0.0674 mL | 0.3372 mL | 0.6744 mL | 1.6859 mL | |
| 25 mM | 0.0539 mL | 0.2697 mL | 0.5395 mL | 1.3487 mL | |
| 30 mM | 0.0450 mL | 0.2248 mL | 0.4496 mL | 1.1239 mL | |
| 40 mM | 0.0337 mL | 0.1686 mL | 0.3372 mL | 0.8429 mL | |
| 50 mM | 0.0270 mL | 0.1349 mL | 0.2697 mL | 0.6744 mL | |
| 60 mM | 0.0225 mL | 0.1124 mL | 0.2248 mL | 0.5620 mL | |
| 80 mM | 0.0169 mL | 0.0843 mL | 0.1686 mL | 0.4215 mL | |
| 100 mM | 0.0135 mL | 0.0674 mL | 0.1349 mL | 0.3372 mL |
PTP1B-IN-4 Related Classifications
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