1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. PTP1B-IN-4

PTP1B-IN-4 

Cat. No.: HY-15756
Handling Instructions

PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC50 of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes.

For research use only. We do not sell to patients.

PTP1B-IN-4 Chemical Structure

PTP1B-IN-4 Chemical Structure

CAS No. : 765317-72-4

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Description

PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC50 of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes[1][2].

IC50 & Target

IC50: 8 μM (PTP1B)[1]

In Vitro

PTP1B-IN-4 (250 µM; 1 hour) stimulates insulin receptor (IR) phosphorylation in CHO cells overexpressing human IR[1].
PTP1B-IN-4 also induces phosphorylation of IRS-1 and Akt, proteins downstream of the insulin receptor[1].

Western Blot Analysis[1]

Cell Line: CHO cells
Concentration: 250 µM
Incubation Time: 1 hour
Result: Stimulated insulin receptor phosphorylation.
Molecular Weight

741.45

Formula

C₂₆H₁₉Br₂N₃O₇S₃

CAS No.

765317-72-4

SMILES

O=S(C1=CC=C2C(C(C3=CC(Br)=C(O)C(Br)=C3)=O)=C(CC)OC2=C1)(NC4=CC=C(S(=O)(NC5=NC=CS5)=O)C=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

PTP1B-IN-4PhosphataseproteintyrosinephosphatasePTP1BobesitydiabetesInhibitorinhibitorinhibit

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