1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. DPM-1001

DPM-1001 

Cat. No.: HY-121515
Handling Instructions

DPM-1001 is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM. DPM-1001 is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 has anti-diabetic property.

For research use only. We do not sell to patients.

DPM-1001 Chemical Structure

DPM-1001 Chemical Structure

CAS No. : 1471172-27-6

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Description

DPM-1001 is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM. DPM-1001 is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 has anti-diabetic property[1].

IC50 & Target

IC50: 100 nM (PTP1B)[1]

In Vitro

DPM-1001 inhibits the short form of PTP1B reversibly, whereas PTP1B(1–405) remained inactive over an extended period of time. DPM-1001 is against PTP1B(1–405) with no pre-incubation, the IC50 value for PTP1B(1–405) is 600 nM. However, after a 30-min pre-incubation, the potency is improved to 100 nM. In contrast, there is no obvious time-dependent change in the IC50 value for PTP1B(1–321)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DPM-1001 (oral or intraperitoneal administration; 5 mg/kg; once daily; 50 days) inhibits diet-induced obesity in mice by improving insulin and leptin signaling. DPM-1001-treated, high-fat diet-fed mice starts losing weight within 5 days of treatment. The weight loss continues for approximately 3 weeks, after which no further decrease in body weight is observed[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 18 weeks of age, high-fat diet (HFD)-fed obese male mice (C57bl6/J)[1]
Dosage: 5 mg/kg
Administration: Oral or intraperitoneal administration; 5 mg/kg; once daily; 50 days
Result: Led to an 5% decrease in body weight.
Improved glucose tolerance and insulin sensitivity in glucose tolerance and insulin tolerance in vivo.
Molecular Weight

567.85

Formula

C35H57N3O3

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Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
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DPM-1001
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