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Results for "

adenosine production

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Kinase (1) Adenosine Receptor (15) 5-HT Receptor (1) Adrenergic Receptor (5) AMPK (5) Amyloid-β (1) Antibiotic (3) Apoptosis (2) Autophagy (5) Bacterial (5) Bcl-2 Family (1) Calcium Channel (5) CD73 (9) CGRP Receptor (1) CRFR (1) Cyclic GMP-AMP Synthase (1) Cytochrome P450 (2) Dopamine Receptor (6) Endogenous Metabolite (7) ERK (1) Estrogen Receptor/ERR (1) IFNAR (1) Interleukin Related (2) Isotope-Labeled Compounds (4) JNK (1) mAChR (5) Mitophagy (5) MMP (2) NTPDase (1) Nucleoside Antimetabolite/Analog (1) Phosphodiesterase (PDE) (1) Pyruvate Kinase (1) Reactive Oxygen Species (ROS) (1) Reference Standards (6) STING (1) Thymidylate Synthase (1) TNF Receptor (1) Toll-like Receptor (TLR) (1) YAP (5)
By Research Areas:	Cancer (21) Cardiovascular Disease (7) Infection (8) Inflammation/Immunology (14) Metabolic Disease (2) Neurological Disease (12)
Oligonucleotides:	Nucleotide Analogs (1) Adenine Nucleotide (1)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Adenosine Kinase Adenosine Deaminase Adenosine Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13417

AICAR Maximum Cited Publications 215 Publications Verification Acadesine; AICA Riboside	AMPK Autophagy YAP Mitophagy Endogenous Metabolite	Cancer
AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR is also an autophagy, YAP and mitophagy inhibitor. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR inhibits autophagy through a mechanism independent of AMPK activity .

HY-13417A

AICAR phosphate Maximum Cited Publications 215 Publications Verification Acadesine phosphate; AICA Riboside phosphate	AMPK Autophagy YAP Mitophagy Endogenous Metabolite	Cancer
AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR phosphate is also an autophagy, YAP and mitophagy inhibitor .

HY-N0113

Hordenine 1 Publications Verification Ordenina; Peyocactine	Bacterial Antibiotic	Infection Cardiovascular Disease
Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-118341

Clitocine	Apoptosis Bcl-2 Family	Cancer
Clitocine, an adenosine nucleoside analog isolated from mushroom, is a potent and efficacious readthrough agent. Clitocine acts as a suppressor of nonsense mutations and can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity .

HY-B0549A

Flavoxate hydrochloride Rec-7-0040; DW61	Calcium Channel Adenosine Receptor mAChR Dopamine Receptor Adrenergic Receptor	Cardiovascular Disease Infection Neurological Disease Cancer
Flavoxate hydrochloride (Rec-7-0040; DW61) is an orally active L-type Ca ²⁺ channel inhibitor and antispasmodic. Flavoxate hydrochloride inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba ²⁺ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate hydrochloride induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate hydrochloride effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate hydrochloride can be used in research on overactive bladder and related voiding dysfunctions .

HY-13417R

AICAR (Standard) Acadesine (Standard); AICA Riboside (Standard)	Reference Standards AMPK Autophagy YAP Mitophagy Endogenous Metabolite	Cancer
AICAR (Standard) is the analytical standard of AICAR. This product is intended for research and analytical applications. AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy, YAP and mitophagy inhibitor .

HY-W587488

Adenosine 3′-monophosphate 3′-AMP	Nucleoside Antimetabolite/Analog Cyclic GMP-AMP Synthase	Cancer
Adenosine 3’-monophosphate (3’-AMP) is a nucleotide. Adenosine 3’-monophosphate is a cyclic AMP production agonist. Adenosine 3’-monophosphate increases cyclic AMP levels concentration-dependently in NG108-15 cells. Adenosine 3’-monophosphate can be used in the determination of acid phosphatase activity of human serum, which is estabilished as a laboratory procedure in the diagnosis of prostate cancer, metastatic mammary cancer and Gaucher’s disease. Adenosine 3’-monophosphate inhibits human aortic and coronary vascular smooth muscle cell proliferation via A_2B receptors .

HY-124151

Adenosine-2'-monophosphate 2'-AMP; adenosine 2'-phosphate; AMP 2'-phosphate	Adenosine Receptor Endogenous Metabolite	Neurological Disease
Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A_2A receptor activation .

HY-160696

ORIC-533	CD73	Cancer
ORIC-533 is an orally active, highly selective, AMP-competitive CD73 inhibitor that potently blocks *adenosine* production with sub-nanomolar affinity (K_a=0.03 nM). In multiple myeloma, ORIC-533 restores and enhances the cytotoxicity of the immune system against tumor cells through multiple immunological mechanisms, including reversing the immunosuppressive microenvironment, inducing immunogenic cell death, and activating dendritic cells, T cells and NK cells, with no direct toxicity to normal cells. The combination of ORIC-533 with Daratumumab (HY-P9915) synergistically enhances anti-tumor efficacy, significantly increases intratumoral CD8 ⁺ T cell infiltration and inhibits tumor growth in vivo .

HY-160230

ssRNA41 sodium	Toll-like Receptor (TLR)	Infection
ssRNA41 sodium is a 20-mer phosphothioate protected single-stranded RNA oligonucleotide. It derives from ssRNA40 by replacement of all U nucleotides with adenosine. ssRNA41 sodium is unable to induce the production of type IFNs, and therefore can be used as a negative control for ssRNA40 .

HY-N0092R

Inosine (Standard)	Reference Standards Adenosine Receptor Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Inosine (Standard) is the analytical standard of Inosine. This product is intended for research and analytical applications. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors . In Vitro:Inosine dose-dependently stimulates cAMP production mediated through the A_2AR . Inosine dose-dependently induces hA_2AR-mediated ERK1/2 phosphorylation . Inosine (100 μM; 24 hours) reduces oxidative stress in MES 23.5 cells cultured with astrocytes . In Vivo:Inosine (10-100 mg/kg; i.p.) exhibits antinociceptive effect in mice .

HY-173178

LNS8801	Estrogen Receptor/ERR	Cancer
LNS8801 is an orally active agonist of the G protein-coupled estrogen receptor (GPER). By activating GPER, LNS8801 mediates downstream signaling pathways, such as promoting the production of cyclic adenosine monophosphate (cAMP) and activating the cAMP response element-binding protein (CREB) signaling, thereby exerting anti-tumor activities including inhibiting tumor cell proliferation, inducing cell differentiation, and enhancing tumor immunogenicity. LNS8801 can be used in the research of various cancers (e.g., melanoma, pancreatic cancer, colorectal cancer, lung cancer, etc.) and relevant studies exploring the roles of GPER in normal physiological and pathological processes .

HY-105017

Evodenoson ATL 313; DE 112	Adenosine Receptor	Infection Inflammation/Immunology
Evodenoson is a selective agonist of the *A_2A adenosine* receptor*. Evodenoson’s primary actions include reducing inflammatory responses, decreasing intestinal fluid secretion, edema, tissue damage, and neutrophil infiltration induced by Clostridium difficile* toxin A. Evodenoson’s protective effect is achieved by reducing myeloperoxidase (MPO) and adenosine deaminase (ADA) activities, and by lowering the production of tumor necrosis factor-alpha (TNF-α) .

HY-176296

Vizenpistat SR-8541A	Phosphodiesterase (PDE) STING	Cancer
Vizenpistat (SR-8541A) is an orally active ENPP1 inhibitor. Vizenpistat increases cGAMP levels, blocks 2′3′-cGAMP hydrolysis, inhibits adenosine production, regulates innate immune signaling mediated by the STING pathway, and modulates anti-tumor immune responses. Vizenpistat is applicable to research related to breast cancer and metastatic microsatellite-stable colorectal cancer .

HY-N0113B

Hordenine hydrochloride 1 Publications Verification Ordenina hydrochloride; Peyocactine hydrochloride	Bacterial	Infection
Hordenine (hydrochloride), an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-N0113S

Hordenine-d6 Ordenina-d₆; Peyocactine-d₆	Isotope-Labeled Compounds Bacterial Antibiotic	Infection Cardiovascular Disease
Hordenine-d6 (Ordenina-d6) is the deuterium labeled Hordenine. Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-103178

MRE3008F20	Adenosine Receptor	Inflammation/Immunology
MRE3008F20 is a highly efficient, highly selective and radioactive adenosine A₃ receptor (AA₃R) antagonist (K_i=1.8 nM). MRE3008F20 effectively antagonises Cl-IB-MECA-induced cAMP production in resting lymphocytes with an IC₅₀ value of 5 nM. MRE3008F20 can be used in the study of AA3R .

HY-136978

OP-5244	CD73	Inflammation/Immunology Cancer
OP-5244 is a potent and orally active inhibitor of CD73, with an IC₅₀ of 0.25 nM. OP-5244 reverses immunosuppression through blocking of adenosine production, and has the potential for the cancer research .

HY-13417AR

AICAR phosphate (Standard) Acadesine phosphate (Standard); AICA Riboside phosphate (Standard)	AMPK Autophagy YAP Mitophagy Endogenous Metabolite Reference Standards	Cancer
AICAR (phosphate) (Standard) is the analytical standard of AICAR (phosphate). This product is intended for research and analytical applications. AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR phosphate is also an autophagy, YAP and mitophagy inhibitor .

HY-B0549

Flavoxate Rec-7-0040 free base; DW61 free base	mAChR Calcium Channel Adrenergic Receptor Adenosine Receptor Dopamine Receptor	Neurological Disease
Flavoxate (Rec-7-0040 free base; DW61 free base) is an orally active L-type Ca ²⁺ channel inhibitor and antispasmodic. Flavoxate inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba ²⁺ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate can be used in research on overactive bladder and related voiding dysfunctions .

HY-B0549AR

Flavoxate hydrochloride (Standard) Rec-7-0040 (Standard); DW61 (Standard)	Reference Standards mAChR Calcium Channel Adrenergic Receptor Adenosine Receptor Dopamine Receptor	Neurological Disease
Flavoxate (hydrochloride) (Standard) is the analytical standard of Flavoxate (hydrochloride). This product is intended for research and analytical applications. Flavoxate hydrochloride (Rec-7-0040; DW61) is an orally active L-type Ca ²⁺ channel inhibitor and antispasmodic. Flavoxate hydrochloride inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba ²⁺ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate hydrochloride induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate hydrochloride effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate hydrochloride can be used in research on overactive bladder and related voiding dysfunctions .

HY-147590

CD73-IN-9	CD73	Inflammation/Immunology
CD73-IN-9 (compound 2) is a potent inhibitor of CD73. CD73 can catalyze the production of adenosine from extracellular 5'-phosphate adenosine (5'-AMP), and adenosine can induce immunosuppressive effects and promote tumor proliferation and/or metastasis. CD73-IN-9 can be used for the study of tumor-related diseases .

HY-179248

Adenosine receptor antagonist 7	Adenosine Receptor ERK JNK MMP	Cancer
Adenosine receptor antagonist 7 is an orally active triple A1/A2A/A2B adenosine receptor antagonist with K_i values of 1.5, 0.6 and 21 nM. Adenosine receptor antagonist 7 shows potent inhibitory activity (IC₅₀ = 0.8 nM) of cAMP production in A2AR-HEK293 cells. Adenosine receptor antagonist 7 can enhance infiltration of effector T cells and increase the CD8+/Treg ratio companied with Avelumab (HY-108730). Adenosine receptor antagonist 7can be used for the research of cancer, such as colon cancer .

HY-174986

CGRP antagonist 7	CGRP Receptor	Cardiovascular Disease
CGRP antagonist 7 is a potent calcitonin gene-related peptide receptor (CGRP) antagonist with a K_i of 0.029 nM. CGRP antagonist 7 Inhibit the production of cyclic adenosine monophosphate (cAMP) with an IC₅₀ of 1.5 nM. CGRP antagonist 7 can be used for the study of migraine .

HY-13417S

AICAR-13C2,15N Acadesine-¹³C₂,¹⁵N; AICA Riboside-¹³C₂,¹⁵N	Isotope-Labeled Compounds Endogenous Metabolite YAP AMPK Mitophagy Autophagy	Others
AICAR- ¹³C₂, ¹⁵N (Acadesine- ¹³C₂, ¹⁵N; AICA Riboside- ¹³C₂, ¹⁵N) is the ¹³C and ¹⁵N labeled AICAR (HY-13417) . AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy, YAP and mitophagy inhibitor .

HY-137370

2-Hexynyl-5′-N-ethylcarboxamidoadenosine HENECA; 2-Hexynyl-NECA	Adenosine Receptor Amyloid-β	Neurological Disease
2-Hexynyl-5′-N-ethylcarboxamidoadenosine (HENECA) is a selective *A_2A adenosine* receptor** agonist. 2-Hexynyl-5′-N-ethylcarboxamidoadenosine increases intracellular cAMP level, and inhibits TNFα-evoked MMP-3 release. 2-Hexynyl-5′-N-ethylcarboxamidoadenosine induces Aβ42 production in SH-SY5Y cells .

HY-N9515

Diallyl tetrasulfide	Apoptosis Reactive Oxygen Species (ROS)	Neurological Disease Metabolic Disease
Diallyl tetrasulfide is an orally active diallyl tetrasulfide. Diallyl tetrasulfide ameliorates cadmium-induced changes in acetylcholinesterase and adenosine triphosphatase activities as well as oxidative stress injury in the brain of rats . Diallyl tetrasulfide inhibits lipid peroxidation in rat liver microsomes . Diallyl tetrasulfide ameliorates cadmium-induced oxidative liver injury in rats . Diallyl tetrasulfide protects cells against cadmium-induced loss of cell viability, reduces apoptosis rate and ROS production. Diallyl tetrasulfide is applicable to research related to cadmium-induced neurotoxicity and cadmium-induced oxidative liver injury .

HY-137717A

COPCP trisodium	CD73	Cancer
COPCP trisodium (Compound 7a) is a potent and selective ecto-5'-nucleotidase CD73 inhibitor. COPCP trisodium blocks CD73-mediated adenosine production, reducing the inhibitory effect of adenosine on immune cells. COPCP trisodium is promising for research of cancers .

HY-N0113BR

Hordenine hydrochloride (Standard) Ordenina hydrochloride (Standard); Peyocactine hydrochloride (Standard)	Reference Standards Bacterial	Infection
Hordenine (hydrochloride) (Standard) is the analytical standard of Hordenine (hydrochloride). This product is intended for research and analytical applications. Hordenine (hydrochloride), an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production[1].

HY-175195

Adenosine receptor antagonist 6	Adenosine Receptor Interleukin Related IFNAR Cytochrome P450	Inflammation/Immunology Cancer
Adenosine receptor antagonist 6 is an orally active and selective *A_2A adenosine* receptor (A_2AAR) antagonist, with a K_i** of 19.18 nM. Adenosine receptor antagonist 6 inhibits 5’-N-ethylcarboxamide adenosine (NECA) (HY-103173)-mediated cAMP production (IC₅₀ = 0.089 μM) and immunosuppression, while promoting IL-2 and IFN-γ secretion. Adenosine receptor antagonist 6 abolishes the immunosuppressive effects of adenosine on T-cell activation and cytokine release. Adenosine receptor antagonist 6 inhibits tumor growth in a CT26/MC38 xenograft model. Adenosine receptor antagonist 6 can be used for the study of colon cancer .

HY-147592

CD73-IN-11	CD73	Inflammation/Immunology Cancer
CD73-IN-11 (compound 24) is a potent inhibitor of CD73. CD73 can catalyze the production of adenosine from extracellular 5'-phosphate adenosine (5'-AMP), and adenosine can induce immunosuppressive effects and promote tumor proliferation and/or metastasis. CD73-IN-11 can be used for the study of tumor-related diseases .

HY-147591

CD73-IN-10	CD73	Inflammation/Immunology Cancer
CD73-IN-10 (compound 4) is a potent inhibitor of CD73. CD73 can catalyze the production of adenosine from extracellular 5'-phosphate adenosine (5'-AMP), and adenosine can induce immunosuppressive effects and promote tumor proliferation and/or metastasis. CD73-IN-10 can be used for the study of tumor-related diseases .

HY-147589

CD73-IN-8	CD73	Cancer
CD73-IN-8 (compound 57) is a potent inhibitor of CD73. CD73 can catalyze the production of adenosine from extracellular 5'-phosphate adenosine (5'-AMP), and adenosine can induce immunosuppressive effects and promote tumor proliferation and/or metastasis. CD73-IN-8 can be used for the study of tumor-related diseases .

HY-147588

CD73-IN-7	CD73	Cancer
CD73-IN-7 (compound 13) is a potent inhibitor of CD73. CD73 can catalyze the production of adenosine from extracellular 5'-phosphate adenosine (5'-AMP), and adenosine can induce immunosuppressive effects and promote tumor proliferation and/or metastasis. CD73-IN-7 can be used for the study of tumor-related diseases .

HY-N0113R

Hordenine (Standard) Ordenina (Standard); Peyocactine (Standard)	Reference Standards Bacterial Antibiotic	Infection Cardiovascular Disease
Hordenine (Standard) is the analytical standard of Hordenine. This product is intended for research and analytical applications. Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-136978A

OP-5244 sodium	CD73	Inflammation/Immunology Cancer
OP-5244 sodium is a potent and orally active inhibitor of CD73, with an IC₅₀ of 0.25 nM. OP-5244 sodium reverses immunosuppression through blocking of adenosine production, and has the potential for the cancer research .

HY-117569

KF24345 free base	TNF Receptor	Inflammation/Immunology
KF24345 free base is an orally active adenosine uptake inhibitor. KF24345 free base inhibits adenosine uptake by human, mouse, rabbit and hamster erythrocytes with IC₅₀ values of 59.5, 130.1, 104.2 and 30.9 nM, respectively. KF24345 free base has anti-inflammatory activity and can inhibit LPS-induced TNF-α production and leukopenia in mice .

HY-14132

BMS-665053	CRFR	Neurological Disease
BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC₅₀ = 1.0 nM). BMS-665053)11 is a potent inhibitor of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC₅₀ = 4.9 nM) .

HY-158180

A3AR agonist 4	Adenosine Receptor	Inflammation/Immunology
A3AR agonist 4 is an *A3 adenosine* receptor (A3AR) agonist (K_i*: 1.24 nM for hA3AR). A3AR agonist 4 inhibits cAMP production* with an EC₅₀ of 0.17 nM. A3AR agonist 4 can be used for research of inflammation and pain .

HY-12689C

Mitapivat hydrochloride AG-348 hydrochloride	Pyruvate Kinase	Cardiovascular Disease Metabolic Disease
Mitapivat (AG-348) hydrochloride is an orally active and selective allosteric pyruvate kinase R (PK-R) activator. Mitapivat hydrochloride accelerates the reaction of PK-R catalyzing the conversion of phosphoenolpyruvate to pyruvate, thereby promoting the glycolytic pathway, increasing the production of adenosine triphosphate (ATP) in red blood cells, and reducing the level of 2,3-diphosphoglycerate (2,3-DPG). Mitapivat hydrochloride is promising for research of pyruvate kinase deficiency and other anemia-related diseases .

HY-B0549S

Flavoxate-d5	Isotope-Labeled Compounds mAChR Calcium Channel Adrenergic Receptor Adenosine Receptor Dopamine Receptor	Others
Flavoxate-d₅ is deuterium labeled Flavoxate. Flavoxate hydrochloride (Rec-7-0040; DW61) is an orally active L-type Ca ²⁺ channel inhibitor and antispasmodic. Flavoxate hydrochloride inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba ²⁺ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate hydrochloride induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate hydrochloride effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate hydrochloride can be used in research on overactive bladder and related voiding dysfunctions .

HY-B0549AS

Flavoxate-d4 hydrochloride	Isotope-Labeled Compounds mAChR Calcium Channel Adrenergic Receptor Adenosine Receptor Dopamine Receptor	Neurological Disease
Flavoxate-d₄ hydrochloride (Rec-7-0040-d₄) is the deuterium labeled Flavoxate hydrochloride. Flavoxate hydrochloride (Rec-7-0040; DW61) is an orally active L-type Ca ²⁺ channel inhibitor and antispasmodic. Flavoxate hydrochloride inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba ²⁺ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate hydrochloride induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate hydrochloride effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate hydrochloride can be used in research on overactive bladder and related voiding dysfunctions .

HY-182714

N 0840 N6-Cyclopentyl-9-methyladenine	Adenosine Receptor	Cardiovascular Disease Neurological Disease
N 0840 is a neutral antagonist of adenosine A₁ receptor (A₁AR), with a K_i value of 279 nM in rats and 1185 nM in humans. N 0840 modulates adenosine A₁ receptor to increase forskolin-induced cyclic 3′,5′-adenosine monophosphate production, with a GTP shift value close to 1. N 0840 can be used in studies of neuroprotection, cardiovascular/renal function^[1].

HY-404647

FK3453	Interleukin Related Adenosine Receptor	Neurological Disease Inflammation/Immunology
FK3453 is a dual adenosine A1/A2 inhibitor and a TSLP inhibitor. FK3453 is also a substrate of aldehyde oxidase (AO). FK3453 can inhibit the production of TSLP and IL-33. FK3453 is useful for research on Parkinson’s disease and allergic disorders .

HY-P992446

PUR001	NTPDase	Cancer
PUR001 is a monoclonal antibody targeting NTPDase 1 (CD39). PUR001 blocks the hydrolysis of extracellular ATP and ADP into AMP by inhibiting CD39, reduces the production of immunosuppressive adenosine, and increases extracellular ATP concentration to activate anti-tumor immune responses. PUR001 can be used in studies related to solid tumors .

HY-183973

MTXPG5	Thymidylate Synthase	Inflammation/Immunology Cancer
MTXPG5 is a long-chain Methotrexate (HY-14519) metabolite and thymidylate synthase inhibitor with a K_i of 0.047 μM. MTXPG5 inhibits 5-aminoimidazole-4-carboxamide ribonucleotide transformylase, interferes with DNA synthesis and immune cell proliferation, and inhibits pro-inflammatory cytokine production via extracellular adenosine accumulation and elevated cAMP levels. MTXPG5 can be used for the research of leukaemia and rheumatoid arthritis .

HY-182503

GP515	Adenosine Kinase	Others Inflammation/Immunology
GP515 is a potent and selective adenosine kinase inhibitor with a human IC₅₀ of 4 nM. GP515 exerts tissue protective effects, produces long-lasting hepatic microcirculation effects after hemorrhagic shock, and induces dose- and time-related VEGF mRNA and protein expression in normoxic rat myocardial myoblasts, with additive VEGF increases during mild hypoxia and no effect during severe hypoxia. GP515 suppresses IFNγ synthesis and CD69 expression in DSS-induced colitis. GP515 also shows a dose-dependent suppression of TNF-α production with an IC₅₀ of 80 μM and can be reversed in the presence of the cAMP antagonist (Rp)-cAMPS. Combinations of GP515 with either adenosine or rolipram led to an additive inhibition of TNF-α synthesis. GP515 can be used for the research of hemorrhagic shock .

HY-179724

PZ-1657	5-HT Receptor Dopamine Receptor MMP Cytochrome P450	Neurological Disease
PZ-1657 (Compound 57) is an orally active, blood-brain barrier permeable, highly selective, and metabolically stable 5-HT₇ receptor inverse agonist with a K_i value of 5 nM. PZ-1657 inhibits constitutive cyclic adenosine monophosphate (cAMP) production mediated by the Gs signaling pathway (EC₅₀ value of 2.93 nM). PZ-1657 inhibits CYP3A4 P450 (IC₅₀ = 12.2 μM) and hERG channels. PZ-1657 reduces 5-HT₇ receptor-mediated MMP-9 activity. PZ-1657 reverses Phencyclidine-induced cognitive impairment. PZ-1657 possesses antidepressant properties .

Cat. No.	Product Name	Target	Research Area	Image

HY-P992446

PUR001	NTPDase	Cancer
PUR001 is a monoclonal antibody targeting NTPDase 1 (CD39). PUR001 blocks the hydrolysis of extracellular ATP and ADP into AMP by inhibiting CD39, reduces the production of immunosuppressive adenosine, and increases extracellular ATP concentration to activate anti-tumor immune responses. PUR001 can be used in studies related to solid tumors .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13417

AICAR Maximum Cited Publications 215 Publications Verification Acadesine; AICA Riboside	Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	AMPK Autophagy YAP Mitophagy Endogenous Metabolite
AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR is also an autophagy, YAP and mitophagy inhibitor. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR inhibits autophagy through a mechanism independent of AMPK activity .

HY-13417A

AICAR phosphate Maximum Cited Publications 215 Publications Verification Acadesine phosphate; AICA Riboside phosphate	Alkaloids Animals Classification of Application Fields Other Alkaloids Disease Research Fields Source Classification Cancer	AMPK Autophagy YAP Mitophagy Endogenous Metabolite
AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR phosphate is also an autophagy, YAP and mitophagy inhibitor .

HY-N0113

Hordenine 1 Publications Verification Ordenina; Peyocactine	Cardiovascular Disease Alkaloids Monophenols other families Classification of Application Fields Other Alkaloids Phenols Plants Disease Research Fields Source Classification	Bacterial Antibiotic
Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-118341

Clitocine	Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Disease Research Fields Source Classification Cancer	Apoptosis Bcl-2 Family
Clitocine, an adenosine nucleoside analog isolated from mushroom, is a potent and efficacious readthrough agent. Clitocine acts as a suppressor of nonsense mutations and can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity .

HY-13417R

AICAR (Standard) Acadesine (Standard); AICA Riboside (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Endogenous metabolite Source Classification	Reference Standards AMPK Autophagy YAP Mitophagy Endogenous Metabolite
AICAR (Standard) is the analytical standard of AICAR. This product is intended for research and analytical applications. AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy, YAP and mitophagy inhibitor .

HY-124151

Adenosine-2'-monophosphate 2'-AMP; adenosine 2'-phosphate; AMP 2'-phosphate	Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Adenosine Receptor Endogenous Metabolite
Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A_2A receptor activation .

HY-N0092R

Inosine (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards Adenosine Receptor Endogenous Metabolite
Inosine (Standard) is the analytical standard of Inosine. This product is intended for research and analytical applications. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors . In Vitro:Inosine dose-dependently stimulates cAMP production mediated through the A_2AR . Inosine dose-dependently induces hA_2AR-mediated ERK1/2 phosphorylation . Inosine (100 μM; 24 hours) reduces oxidative stress in MES 23.5 cells cultured with astrocytes . In Vivo:Inosine (10-100 mg/kg; i.p.) exhibits antinociceptive effect in mice .

HY-N0113B

Hordenine hydrochloride 1 Publications Verification Ordenina hydrochloride; Peyocactine hydrochloride	Coryphantha vivipara var arizonica Structural Classification Alkaloids Monophenols Cactaceae Other Alkaloids Phenols Plants Source Classification	Bacterial
Hordenine (hydrochloride), an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-13417AR

AICAR phosphate (Standard) Acadesine phosphate (Standard); AICA Riboside phosphate (Standard)	Alkaloids Structural Classification Animals Other Alkaloids Source Classification	AMPK Autophagy YAP Mitophagy Endogenous Metabolite Reference Standards
AICAR (phosphate) (Standard) is the analytical standard of AICAR (phosphate). This product is intended for research and analytical applications. AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR phosphate is also an autophagy, YAP and mitophagy inhibitor .

HY-N9515

Diallyl tetrasulfide	Structural Classification Natural Products Allium sativum L. Plants Amaryllidaceae Source Classification	Apoptosis Reactive Oxygen Species (ROS)
Diallyl tetrasulfide is an orally active diallyl tetrasulfide. Diallyl tetrasulfide ameliorates cadmium-induced changes in acetylcholinesterase and adenosine triphosphatase activities as well as oxidative stress injury in the brain of rats . Diallyl tetrasulfide inhibits lipid peroxidation in rat liver microsomes . Diallyl tetrasulfide ameliorates cadmium-induced oxidative liver injury in rats . Diallyl tetrasulfide protects cells against cadmium-induced loss of cell viability, reduces apoptosis rate and ROS production. Diallyl tetrasulfide is applicable to research related to cadmium-induced neurotoxicity and cadmium-induced oxidative liver injury .

HY-N0113BR

Hordenine hydrochloride (Standard) Ordenina hydrochloride (Standard); Peyocactine hydrochloride (Standard)	Coryphantha vivipara var arizonica Structural Classification Alkaloids Monophenols Cactaceae Other Alkaloids Phenols Plants Source Classification	Reference Standards Bacterial
Hordenine (hydrochloride) (Standard) is the analytical standard of Hordenine (hydrochloride). This product is intended for research and analytical applications. Hordenine (hydrochloride), an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production[1].

HY-N0113R

Hordenine (Standard) Ordenina (Standard); Peyocactine (Standard)	Cardiovascular Disease Alkaloids other families Classification of Application Fields Phenols Plants Disease Research Fields Source Classification	Reference Standards Bacterial Antibiotic
Hordenine (Standard) is the analytical standard of Hordenine. This product is intended for research and analytical applications. Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

Cat. No.	Product Name	Chemical Structure

HY-N0113S

Hordenine-d6
Hordenine-d6 (Ordenina-d6) is the deuterium labeled Hordenine. Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .

HY-13417S

AICAR-13C2,15N
AICAR- ¹³C₂, ¹⁵N (Acadesine- ¹³C₂, ¹⁵N; AICA Riboside- ¹³C₂, ¹⁵N) is the ¹³C and ¹⁵N labeled AICAR (HY-13417) . AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy, YAP and mitophagy inhibitor .

HY-B0549S

Flavoxate-d5

Flavoxate-d₅ is deuterium labeled Flavoxate. Flavoxate hydrochloride (Rec-7-0040; DW61) is an orally active L-type Ca ²⁺ channel inhibitor and antispasmodic. Flavoxate hydrochloride inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba ²⁺ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate hydrochloride induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate hydrochloride effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate hydrochloride can be used in research on overactive bladder and related voiding dysfunctions .

HY-B0549AS

Flavoxate-d4 hydrochloride

Flavoxate-d₄ hydrochloride (Rec-7-0040-d₄) is the deuterium labeled Flavoxate hydrochloride. Flavoxate hydrochloride (Rec-7-0040; DW61) is an orally active L-type Ca ²⁺ channel inhibitor and antispasmodic. Flavoxate hydrochloride inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba ²⁺ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate hydrochloride induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate hydrochloride effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate hydrochloride can be used in research on overactive bladder and related voiding dysfunctions .

Cat. No.	Product Name		Classification

HY-W587488

Adenosine 3′-monophosphate 3′-AMP		Nucleotide Analogs Adenine Nucleotide
Adenosine 3’-monophosphate (3’-AMP) is a nucleotide. Adenosine 3’-monophosphate is a cyclic AMP production agonist. Adenosine 3’-monophosphate increases cyclic AMP levels concentration-dependently in NG108-15 cells. Adenosine 3’-monophosphate can be used in the determination of acid phosphatase activity of human serum, which is estabilished as a laboratory procedure in the diagnosis of prostate cancer, metastatic mammary cancer and Gaucher’s disease. Adenosine 3’-monophosphate inhibits human aortic and coronary vascular smooth muscle cell proliferation via A_2B receptors .

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