country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-174986

Copy Link Print Information

CGRP antagonist 7

CGRP antagonist 7 is a potent calcitonin gene-related peptide receptor (CGRP) antagonist with a K_i of 0.029 nM. CGRP antagonist 7 Inhibit the production of cyclic adenosine monophosphate (cAMP) with an IC₅₀ of 1.5 nM. CGRP antagonist 7 can be used for the study of migraine.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2173508-07-9
Formule: C₃₀H₃₂FN₅O₃
Masse moléculaire:529.61

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

CGRP antagonist 7 Chemical Structure

CAS No.: 2173508-07-9

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

CGRP antagonist 7 (Compound 15) (0.1-10 μM, 0-60 min) exhibits the IC₅₀ more than 100 μM in human hepatocellular carcinoma (HepaRG) cells and moderate inhibition of CYP3A (IC₅₀ = 6.6 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	AUC_inf	T_1/2	CL_total	V_ss	C_max	T_max	F
Rat^[1].	1 mg/kg	i.v.	36709 min·ng/mL	40 min	28 mL/min/kg	777 mL/kg	/	/	/
Rat^[1].	10 mg/kg	p.o.	408768 min·ng/mL	/	/	/	2906 ng/mL	30 min	111 %

In Vivo

CGRP antagonist 7 (Compound 15) (1 mg/kg, i,p., single dose) significantly inhibits the increase in blood flow induced by CGRP in marmoset facial blood flow mode^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Marmoset facial blood flow mode induced by intravenous administration of hαCGRP at a dose of 10 μg/kg administered at −15, 15, 45, and 90 min^[1]
Dosage:

1 mg/kg
Administration:

Intraperitoneal injection (i.p.), single dose
Result:

Significantly inhibited the increase in facial blood flow induced by CGRP (E_max = 84% at 45 min).

Chemical Information

CAS No. 2173508-07-9
Masse moléculaire 529.61
Formule C₃₀H₃₂FN₅O₃
SMILES

CC1=NNC(C(CC2=CC=C(C=C2C)C(NCC(N3[C@@H](CC[C@@H]3C(C)(C#N)C)C4=CC(F)=CC=C4)=O)=O)=C1)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Morita N, et al. Fragment-Based Discovery of an Oral Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine. J Med Chem. 2025 Jul 24;68(14):14919-14944. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis