2. GPCR/G Protein
  3. Adenosine Receptor
  4. MRE3008F20

MRE3008F20 est un antagoniste de récepteur de l'adénosine A3 (AA3R) qui est très puissant et sélectif, qui inhibe l'élévation de l'AMPc induite par un agoniste dans les lymphocytes T au repos avec un IC50 de 5 nM.

MRE3008F20 is a highly efficient, highly selective and radioactive adenosine A3 receptor (AA3R) antagonist (Ki=1.8 nM). MRE3008F20 effectively antagonises Cl-IB-MECA-induced cAMP production in resting lymphocytes with an IC50 value of 5 nM. MRE3008F20 can be used in the study of AA3R.

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MRE3008F20 Chemical Structure

MRE3008F20 Chemical Structure

CAS No. : 252979-43-4

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Based on 1 publication(s) in Google Scholar

MRE3008F20 Related Antibodies

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

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Description

MRE3008F20 is a highly efficient, highly selective and radioactive adenosine A3 receptor (AA3R) antagonist (Ki=1.8 nM). MRE3008F20 effectively antagonises Cl-IB-MECA-induced cAMP production in resting lymphocytes with an IC50 value of 5 nM. MRE3008F20 can be used in the study of AA3R[1][2].

IC50 & Target

IC50 : 5 nM (AA3R)[1]
In Vitro

MRE3008F20 (0.1-100 nM) antagonizes 100 nM Cl-IB-MECA-induced inhibition of cAMP levels in resting human lymphocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MRE3008F20 Related Antibodies

Cell Viability Assay[1]

Cell Line: Human lymphocytes
Concentration: 0.1-100 nM
Incubation Time:
Result: Antagonized 100 nM Cl-IB-MECA-induced inhibition of cAMP levels with an IC50 of 5.0 nM in resting Lymphocytes.
Molecular Weight

432.44

Formula

C21H20N8O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=C(OC)C=C1)NC2=NC3=NN(CCC)C=C3C4=NC(C5=CC=CO5)=NN24
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥99.0%

COA (251 KB)

Handling Instructions (2659 KB)
References
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MRE3008F20 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MRE3008F20252979-43-4Adenosine ReceptorP1 receptoradenosine receptorlymphocytesradioactiveCl-IB-MECAcAMPInhibitorinhibitorinhibit

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