252979-43-4
Chemical Structure
MRE3008F20
- CAS No.: 252979-43-4
- Formula:C21H20N8O3
- Molecular Weight:432.44
IUPAC Name: 1-(2-(furan-2-yl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-methoxyphenyl)urea
InChIKey: CJRNHKSLHHWUAB-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(OC)C=C1)NC2=NC3=NN(CCC)C=C3C4=NC(C5=CC=CO5)=NN24
Biological Activity: MRE3008F20 is a highly efficient, highly selective and radioactive adenosine A3 receptor (AA3R) antagonist (Ki=1.8 nM). MRE3008F20 effectively antagonises Cl-IB-MECA-induced cAMP production in resting lymphocytes with an IC50 value of 5 nM. MRE3008F20 can be used in the study of AA3R[1][2].
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MRE3008F20 | 98.34% | MRE3008F20 is a highly efficient, highly selective and radioactive adenosine A3 receptor (AA3R) antagonist (Ki=1.8 nM). MRE3008F20 effectively antagonises Cl-IB-MECA-induced cAMP production in resting lymphocytes with an IC50 value of 5 nM. MRE3008F20 can be used in the study of AA3R. | ||||||||||||||||||||
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- [1]. Gessi S, et al. Expression of A3 adenosine receptors in human lymphocytes: up-regulation in T cell activation. Mol Pharmacol. 2004 Mar;65(3):711-9. [Content Brief]
- [2]. Baraldi P G, et al. New potent and selective human adenosine A3 receptor antagonists. Trends in pharmacological sciences, 2000, 21(12): 456-459.
Keywords
