1. Apoptosis
  2. Apoptosis
    Bcl-2 Family
  3. Clitocine

Clitocine 

Cat. No.: HY-118341
Handling Instructions

Clitocine, an adenosine nucleoside analog, is a potent and efficacious readthrough agent. Clitocine can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity.

For research use only. We do not sell to patients.

Clitocine Chemical Structure

Clitocine Chemical Structure

CAS No. : 105798-74-1

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Description

Clitocine, an adenosine nucleoside analog, is a potent and efficacious readthrough agent. Clitocine can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity[1][2].

In Vitro

Clitocine (0-0.8μM; 24 hours) enhances TRAIL-lethality in in LS411N and SW620 cells. Clitocine (0.2μM; 36 hours) significantly potentiates TRAIL-mediated apoptosis[2].

In Vivo

Citocine (0.3-3 mg/kg; s.c.; five times per week)-induced p53 inhibits CAOV-33p53-UAA136 tumor growth in a xenograft model[1].

Animal Model: nu/nu mice (CAOV-3p53-UAA136 xenograft tumors)[1]
Dosage: 0.3, 3 mg/kg (or 20 mg/kg once per week)
Administration: S.c.; five times per week
Result: CAOV-33p53-UAA136 tumor growth was inhibited.
Molecular Weight

287.23

Formula

C₉H₁₃N₅O₆

CAS No.

105798-74-1

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Keywords:

ClitocineApoptosisBcl-2 FamilycoloncancercellsdegradationnonsensemutationreadthroughInhibitorinhibitorinhibit

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