Clitocine 

Clitocine, an adenosine nucleoside analog isolated from mushroom, is a potent and efficacious readthrough agent. Clitocine acts as a suppressor of nonsense mutations and can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity^[1][2].

Clitocine incorporation into mRNA is required for premature stop codon readthrough activity, and the presence of clitocine at the third position of a premature stop codon is sufficient to promote robust readthrough^[1].
Clitocine (0-0.8 μM; 24 hours) enhances TRAIL-lethality in in LS411N and SW620 cells. Clitocine (0.2μM; 36 hours) significantly potentiates TRAIL-mediated apoptosis^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Citocine (0.3-3 mg/kg; s.c.; five times per week)-induced p53 inhibits CAOV-33_p53-UAA136 tumor growth in a xenograft model^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

287.23

Solid

C₉H₁₃N₅O₆

105798-74-1

OC[[email protected]@H]1[[email protected]@H](O)[[email protected]@H](O)[[email protected]](NC2=C([N+]([O-])=O)C(N)=NC=N2)O1

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• [1]. Friesen WJ, et al. The nucleoside analog clitocine is a potent and efficacious readthrough agent. RNA. 2017;23(4):567-577.  [Content Brief]

  [2]. Sun JG, et al. Clitocine potentiates TRAIL-mediated apoptosis in human colon cancer cells by promoting Mcl-1 degradation. Apoptosis. 2016;21(10):1144-1157.  [Content Brief]