105798-74-1
Chemical Structure
Clitocine
- CAS No.: 105798-74-1
- Formula:C9H13N5O6
- Molecular Weight:287.23
IUPAC Name: (2R,3R,4S,5R)-2-((6-amino-5-nitropyrimidin-4-yl)amino)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
InChIKey: OHEMBWZZEKCBAS-UUOKFMHZSA-N
SMILES: OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](NC2=C([N+]([O-])=O)C(N)=NC=N2)O1
Biological Activity: Clitocine, an adenosine nucleoside analog isolated from mushroom, is a potent and efficacious readthrough agent. Clitocine acts as a suppressor of nonsense mutations and can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Clitocine | 95.0% | Clitocine, an adenosine nucleoside analog isolated from mushroom, is a potent and efficacious readthrough agent. Clitocine acts as a suppressor of nonsense mutations and can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity. | ||||||||||||||||||||
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Clitocine (Standard) | ≥98% | H-Chpro-OH.HCl (Standard) is the analytical standard of H-Chpro-OH.HCl. This product is intended for research and analytical applications. H-Chpro-OH.HCl is a proline derivative. | ||||||||||||||||||||
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- [1]. Friesen WJ, et al. The nucleoside analog clitocine is a potent and efficacious readthrough agent. RNA. 2017;23(4):567-577. [Content Brief]
- [2]. Sun JG, et al. Clitocine potentiates TRAIL-mediated apoptosis in human colon cancer cells by promoting Mcl-1 degradation. Apoptosis. 2016;21(10):1144-1157. [Content Brief]
Keywords
