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Results for "

alcohol dehydrogenases

" in MedChemExpress (MCE) Product Catalog:

標的別:	Aldehyde Dehydrogenase (ALDH) (11) Amyloid-β (1) Angiotensin Receptor (2) Apoptosis (2) Bacterial (1) Biochemical Assay Reagents (1) Cuproptosis (2) Cytochrome P450 (5) Drug Intermediate (1) Drug Metabolite (4) Endogenous Metabolite (12) Environmental Pollutants (1) FXR (1) GABA Receptor (1) iGluR (2) Interleukin Related (2) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (1) Microtubule/Tubulin (1) NF-κB (2) p38 MAPK (2) Parasite (2) Pyroptosis (2) Reactive Oxygen Species (ROS) (1) Reference Standards (7)
研究分野別:	Cancer (3) Cardiovascular Disease (4) Infection (5) Inflammation/Immunology (7) Metabolic Disease (22) Neurological Disease (2)

標的別:

Aldehyde Dehydrogenase (ALDH) (11)

Amyloid-β (1)

Angiotensin Receptor (2)

Apoptosis (2)

Bacterial (1)

Biochemical Assay Reagents (1)

Cuproptosis (2)

Cytochrome P450 (5)

Drug Intermediate (1)

Drug Metabolite (4)

Endogenous Metabolite (12)

Environmental Pollutants (1)

FXR (1)

GABA Receptor (1)

iGluR (2)

Interleukin Related (2)

Isocitrate Dehydrogenase (IDH) (1)

Isotope-Labeled Compounds (1)

Microtubule/Tubulin (1)

NF-κB (2)

p38 MAPK (2)

Parasite (2)

Pyroptosis (2)

Reactive Oxygen Species (ROS) (1)

Reference Standards (7)

研究分野別:

Cancer (3)

Cardiovascular Disease (4)

Infection (5)

Inflammation/Immunology (7)

Metabolic Disease (22)

Neurological Disease (2)

阻害剤およびアゴニスト

生化学アッセイ試薬

ペプチド

天然物

同位体標識化合物

Targets Recommended: 17β-HSD 11β-HSD

製品番号	製品名	Target	研究分野	構造式

HY-B0240

Disulfiram Maximum Cited Publications 141 Publications Verification Tetraethylthiuram disulfide; TETD	Aldehyde Dehydrogenase (ALDH) Interleukin Related Pyroptosis Apoptosis Cuproptosis	Metabolic Disease Cancer
Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram, a copper ion carrier, with Cu ²⁺ increases intracellular ROS levels and induces cuproptosis .

HY-B0876

Fomepizole 4 Publications Verification 4-Methylpyrazole	Cytochrome P450	Metabolic Disease
Fomepizole (4-Methylpyrazole) is a potent cytochrome P450 (CYP2E1) inhibitor. Fomepizole is a competitive inhibitor of the enzyme **alcohol dehydrogenase**. Fomepizole blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole has the potential for an antidote for ethylene glycol or methanol poisoning .

HY-D0845

Nitrosoglutathione 5+ Cited Publications GSNO; RVC-588; S-Nitroso-L-glutathione	Endogenous Metabolite Angiotensin Receptor	Cardiovascular Disease Inflammation/Immunology
Nitrosoglutathione (GSNO), a exogenous NO donor and a substrate for rat alcohol dehydrogenase class III isoenzyme, inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses .

HY-19801

CVT-10216 3 Publications Verification	Aldehyde Dehydrogenase (ALDH)	Neurological Disease
CVT-10216 is a highly selective, reversible *aldehyde dehydrogenase-2 (ALDH-2)* inhibitor with an IC₅₀ of 29 nM. CVT-10216 also has inhibitory effect of ALDH-1 with an IC₅₀ of 1.3 μM. CVT-10216 can reduce excessive alcohol drinking in alcohol-preferring rats and exhibit anxiolytic effects .

HY-N4067

Isochenodeoxycholic acid isoCDCA	FXR Endogenous Metabolite	Metabolic Disease
Isochenodeoxycholic acid (isoCDCA) is a FXR agonist. Isochenodeoxycholic acid activates the activity of FXR and induces the mRNA expression of FXR target genes (Ostβ and Kng1). Isochenodeoxycholic acid serves as a substrate for the liver class I ADH γγ isozyme-mediated 3β-dehydrogenation reaction .

HY-76006

3-Hydroxybenzaldehyde M-Hydroxybenzaldehyde	Aldehyde Dehydrogenase (ALDH) NF-κB p38 MAPK	Cardiovascular Disease Inflammation/Immunology
3-Hydroxybenzaldehyde (3-HBA) is a precursor compound for phenolic compounds like Protocatechuic aldehyde (PCA) (HY-N0295). 3-Hydroxybenzaldehyde, produced by 3-hydroxybenzyl-alcohol dehydrogenase, is a substrate of *aldehyde dehydrogenase* (ALDH)** in rats and humans. 3-Hydroxybenzaldehyde has vasculoprotective effects in vitro and in vivo. 3-Hydroxybenzaldehyde is proming for research of atherosclerosis .

HY-B1229

Isovaleramide 1 Publications Verification 3-Methylbutanamide	GABA Receptor	Neurological Disease Metabolic Disease
Isovaleramide (3-Methylbutanamide) is an orally active anticonvulsant. Isovaleramide inhibits alcohol dehydrogenase (ADH) activity and regulates GABAergic system. Isovaleramide reduces acute kidney injury. Isovaleramide has antiepileptic, anxiolytic, sedative and hypnotic effects[1] .

HY-76228

1H-pyrazole Pyrazole	Parasite iGluR	Infection
1H-pyrazole (Pyrazole) is a five-membered heterocyclic compound, and its derivatives are orally effective antimalarial and antileishmanial agents with the potential to modulate targets such as alcohol dehydrogenase and NMDA receptors. 1H-pyrazole derivatives exhibit inhibitory effects on Plasmodium berghei in infected mice and on promastigotes of Leishmania aethiopica, respectively. 1H-pyrazole can be used in research related to malaria and leishmaniasis .

HY-B0240R

Disulfiram (Standard) Tetraethylthiuram disulfide (Standard); TETD (Standard)	Reference Standards Aldehyde Dehydrogenase (ALDH) Interleukin Related Pyroptosis Apoptosis Cuproptosis	Metabolic Disease Cancer
Disulfiram (Standard) is the analytical standard of Disulfiram. This product is intended for research and analytical applications. Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram + Cu ²⁺ increases intracellular ROS levels triggering apoptosis of ovarian cancer stem cells ^[1-6].

HY-P2740

Alcohol dehydrogenase, Saccharomyces cerevisiae EC 1.1.1.1	Endogenous Metabolite	Metabolic Disease
Alcohol dehydrogenase, Saccharomyces cerevisiae is a dimeric protein in the cytosol of cells. Alcohol dehydrogenase, the key enzyme for alcohol consumption in the body, is the highest expressed in the liver and participates in the detoxification mechanism of environmental alcohol .

HY-118980

Sorbitol dehydrogenase-IN-1	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease
Sorbitol dehydrogenase-IN-1 is a potent and orally active sorbitol dehydrogenase inhibitor with IC₅₀ s of 4, 5 nM for rat and human, respectively. Sorbitol Dehydrogenase (SDH) is an enzyme that belongs to the zinc-containing alcohol dehydrogenase (ADH) family. ADH and ALDH are enzymes that work together to metabolize alcohol .

HY-W007330

2-Bromoacetamide	Aldehyde Dehydrogenase (ALDH) Microtubule/Tubulin	Metabolic Disease
2-Bromoacetamide is a disinfection byproduct. 2-Bromoacetamide can inactivate liver **alcohol dehydrogenase and interfere with microtubule and actin** cytoskeletal function. 2-Bromoacetamide is a potent developmental toxicant in animals .

HY-15374

Frentizole	Amyloid-β	Inflammation/Immunology
Frentizole, an FDA-approved immunosuppressant, is a Aβ-ABAD (binding alcohol dehydrogenase) interaction inhibitor with an IC₅₀ value of 200 μM. Frentizole is used in studies of diseases related to rheumatoid arthritis and systemic lupus erythematosus .

HY-107030

Nitrefazole EMD-15700	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease
Nitrefazole is a 4-nitroimidazole derivative with strong and long lasting inhibition of *aldehyde dehydrogenase* (ALDH)*, an enzyme involved in the metabolism of alcohol*.

HY-W115789

Sodium silicate	Environmental Pollutants Reactive Oxygen Species (ROS)	Others
Sodium silicate is a water-soluble silicate. Sodium silicate is widely used as a binder, particularly in the production of detergents, soaps, and cleaners. Sodium silicate promotes the deposition of suberin polyphenols and lignin at wound sites of potato tubers, accelerates callus structure formation, enhances ROS production, and induces the synthesis of total phenols and flavonoids. Sodium silicate reduces the weight loss rate and disease index of wounded potato tubers during storage .

HY-B0876A

Fomepizole hydrochloride 4 Publications Verification 4-Methylpyrazole hydrochloride	Cytochrome P450	Metabolic Disease
Fomepizole (4-Methylpyrazole) hydrochloride is a potent and orally active cytochrome P450 (CYP2E1) inhibitor. Fomepizole hydrochloride is a competitive inhibitor of the enzyme **alcohol dehydrogenase**. Fomepizole hydrochloride blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole hydrochloride has the potential for an antidote for ethylene glycol or methanol poisoning .

HY-164690A

Nicotinamide-guanine dinucleotide sodium	Endogenous Metabolite	Metabolic Disease
Nicotinamide-guanine dinucleotide sodium, a NAD sodium (HY-B0445A) analog, is an oxidized forms of nicotinamide guanine dinucleotide. Nicotinamide-guanine dinucleotide sodium serves as coenzymes for alcohol dehydrogenase (ADH) in vitro .

HY-W015570

4-Nitrobenzyl alcohol (4-Nitrobenzenemathanol) 4-Nitrobenzenemathanol; 4-Nitrobenzyl alcohol	Biochemical Assay Reagents	Others
4-Nitrobenzyl alcohol (4-Nitrobenzenemathanol) is a nitro compound used as a reactant in drug synthesis. 4-Nitrobenzyl alcohol can be catalyzed to 4-nitrobenzaldehyde by the enzyme encoded by the benzyl alcohol dehydrogenase gene (ntnD) .

HY-P2740B

Alcohol dehydrogenase, yeast	Endogenous Metabolite	Metabolic Disease
Alcohol dehydrogenase, yeast is an alcohol dehydrogenase expressed in yeast. It can catalyze the conversion between ethanol and acetaldehyde, while also reducing NAD or NADP, and it plays a role in glycolysis and aerobic respiration .

HY-N1177

Taraxerone	Aldehyde Dehydrogenase (ALDH)	Inflammation/Immunology
Taraxerone is isolated from Sedum sarmentosum. Taraxerone enhances effects on alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities with EC₅₀ values of 512.42 and 500.16 μM, respectively .

HY-148617

ALDH2 modulator 1	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease
ALDH2 modulator 1 is a potent and orally active *aldehyde dehydrogenase-2 (ALDH2)* modulator. ALDH2 modulator 1 reduces blood alcohol levels in mice .

HY-W587751

Arteannuic alcohol Amorpha-4,11-diene-12-ol	Drug Intermediate	Infection
Arteannuic alcohol (Amorpha-4,11-diene-12-ol) is a precursor substance in the biosynthetic pathway of Artemisinin (HY-B0094). Alcohol dehydrogenase catalyzes the dehydrogenation reaction of chlorogenic alcohol to produce artemisinic aldehyde .

HY-Y0943

Isobutyramide	Drug Metabolite	Cancer
Aldehyde Dehydrogenase Isobutyramide is an orally active liver alcohol dehydrogenase (LADH2) inhibitor. Isobutyramide inhibits ethanol metabolism and enhances differentiation-related gene expression, inducing cell cycle arrest and significantly reducing the growth rate of prostate cancer cells (LNCaP). Isobutyramide is promising for research of advanced prostate cancer .

HY-33914

4-Hydroxymethylpyrazole	Drug Metabolite	Metabolic Disease
4-Hydroxymethylpyrazole is the primary metabolite of Fomepizole (HY-B0876) produced through hepatic oxidative metabolism. 4-Hydroxymethylpyrazole exhibits a plasma concentration that is positively correlated with the administered dosage of Fomepizole, and it demonstrates a relatively short half-life. 4-Hydroxymethylpyrazole demonstrates inhibitory effects on alcohol dehydrogenase (ADH) in both humans and monkeys, but its inhibition constant is significantly higher than that of Fomepizole, rendering its in vivo impact negligible .

HY-B0876R

Fomepizole (Standard) 4-Methylpyrazole (Standard)	Reference Standards Cytochrome P450	Metabolic Disease
Fomepizole (Standard) is the analytical standard of Fomepizole. This product is intended for research and analytical applications. Fomepizole (4-Methylpyrazole) is a potent cytochrome P450 (CYP2E1) inhibitor. Fomepizole is a competitive inhibitor of the enzyme **alcohol dehydrogenase**. Fomepizole blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole has the potential for an antidote for ethylene glycol or methanol poisoning .

HY-107030R

Nitrefazole (Standard) EMD-15700 (Standard)	Aldehyde Dehydrogenase (ALDH) Reference Standards	Metabolic Disease
Nitrefazole (Standard) is the analytical standard of Nitrefazole. This product is intended for research and analytical applications. Nitrefazole is a 4-nitroimidazole derivative with strong and long lasting inhibition of aldehyde dehydrogenase (ALDH), an enzyme involved in the metabolism of alcohol.

HY-N13031

Bellericagenin A	Bacterial	Infection
Bellericagenin A is a pentacyclic triterpenic acid isolated from the bark of Terminalia bellerica. Bellericagenin A exhibits antimicrobial activity. Bellericagenin A exhibits a high affinity to **alcohol dehydrogenase (ADH**), which has the potential for ameliorating the alcoholic liver injury .

HY-Z12431

Silodosin carboxylic acid impurity KMD-3293	Endogenous Metabolite	Metabolic Disease
Silodosin carboxylic acid impurity (KMD-3293) is an inactive silodosin metabolite. Silodosin carboxylic acid impurity is the major metabolite that can be generated via oxidation by alcohol and aldehyde dehydrogenase. Silodosin carboxylic acid impurity can be studied in research for benign prostatic hyperplasia .

HY-D0845R

Nitrosoglutathione (Standard) GSNO (Standard); RVC-588 (Standard); S-Nitroso-L-glutathione (Standard)	Reference Standards Endogenous Metabolite Angiotensin Receptor	Cardiovascular Disease Inflammation/Immunology
Nitrosoglutathione (Standard) (GSNO (Standard)) is the analytical standard of Nitrosoglutathione (HY-D0845). This product is intended for research and analytical applications. Nitrosoglutathione (GSNO), a exogenous NO donor and a substrate for rat alcohol dehydrogenase class III isoenzyme, inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses. x

HY-76006R

3-Hydroxybenzaldehyde (Standard) M-Hydroxybenzaldehyde (Standard)	Reference Standards Aldehyde Dehydrogenase (ALDH) NF-κB p38 MAPK	Cardiovascular Disease Inflammation/Immunology
3-Hydroxybenzaldehyde (Standard) is the analytical standard of 3-Hydroxybenzaldehyde. This product is intended for research and analytical applications. 3-Hydroxybenzaldehyde (3-HBA) is a precursor compound for phenolic compounds like Protocatechuic aldehyde (PCA) (HY-N0295). 3-Hydroxybenzaldehyde, produced by 3-hydroxybenzyl-alcohol dehydrogenase, is a substrate of aldehyde dehydrogenase (ALDH) in rats and humans. 3-Hydroxybenzaldehyde has vasculoprotective effects in vitro and in vivo. 3-Hydroxybenzaldehyde is proming for research of atherosclerosis[1][2][3][4].

HY-76228R

1H-pyrazole (Standard) Pyrazole (Standard)	Reference Standards Parasite iGluR	Infection Inflammation/Immunology
1H-pyrazole (Standard) is the analytical standard of 1H-pyrazole. This product is intended for research and analytical applications. 1H-pyrazole (Pyrazole) is a five-membered heterocyclic compound, and its derivatives are orally effective antimalarial and antileishmanial agents with the potential to modulate targets such as alcohol dehydrogenase and NMDA receptors. 1H-pyrazole derivatives exhibit inhibitory effects on Plasmodium berghei in infected mice and on promastigotes of Leishmania aethiopica, respectively. 1H-pyrazole can be used in research related to malaria and leishmaniasis .

HY-W150407

2-Tridecanol	Endogenous Metabolite	Others
2-Tridecanol is a metabolite that can be found in extra virgin coconut oil, and serves as a growth substrate for Pseudomonas multivorans. 2-Tridecanol can be metabolized by Pseudomonas multivorans and Pseudomonas aeruginosa to produce 2-tridecanone, undecyl acetate, and 1-undecanol, and acts as a metabolic intermediate in their 2-tridecanone catabolic pathway .

HY-N17378

Camelliquercetiside B	Others	Others
Camelliquercetiside B is a natural product. Camelliquercetiside B can be isolated from the leaves of Camellia sinensis. Camelliquercetiside B inhibits alcohol dehydrogenase (Alcohol *dehydrogenase), with an IC₅₀* of 13.7 μM against yeast alcohol dehydrogenase. Camelliquercetiside B exhibits scavenging activity against DPPH free radicals .

HY-33914R

4-Hydroxymethylpyrazole (Standard)	Drug Metabolite Reference Standards	Metabolic Disease
4-Hydroxymethylpyrazole (Standard) is an analytical standard for 4-Hydroxymethylpyrazole (HY-33914). This product is intended for research and analytical applications. 4-Hydroxymethylpyrazole is the primary metabolite of fomepizole (HY-B0876) via hepatic oxidative metabolism. 4-Hydroxymethylpyrazole exhibits a plasma concentration that is positively correlated with the administered dosage of Fomepizole, and it demonstrates a relatively short half-life. 4-Hydroxymethylpyrazole inhibits alcohol dehydrogenase (ADH) in humans and monkeys, but the inhibition constant is much higher than that of fomepizole and is therefore negligible in vivo

HY-N17379

Camelliquercetiside D	Others	Others
Camelliquercetiside D is a natural product. Camelliquercetiside D can be isolated from the leaves of Camellia sinensis. Camelliquercetiside D inhibits **alcohol dehydrogenase, with an IC₅₀ of 41.5 μM against yeast ADH**. Camelliquercetiside D exhibits scavenging activity against DPPH .

HY-P2740C

Alcohol Dehydrogenase(NADP+ dependent), Thermoanaerobium brockii	Endogenous Metabolite	Metabolic Disease
Alcohol Dehydrogenase(NADP+ dependent), Thermoanaerobium brockii (EC 1.1.1.2) is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue.

HY-E70398A

Sorbitol Dehydrogenase, Sheep	Endogenous Metabolite	Metabolic Disease
Sorbitol dehydrogenase, Sheep (EC 1.1.1.14) is an enzyme in carbohydrate metabolism that converts sorbitol, the sugar alcohol form of glucose, into fructose. Sorbitol dehydrogenase works in conjunction with aldose reductase, enabling the body to utilize glucose to produce fructose without ATP consumption. Sorbitol dehydrogenase uses NAD+ as a cofactor, and zinc ions also participate in the catalytic process.

HY-E70931

*Aromatic Alcohol* Dehydrogenase(NADP+ dependent), Thermoanaerobium sp.**	Endogenous Metabolite	Metabolic Disease
Aromatic Alcohol Dehydrogenase (NADP+ dependent), Thermoanaerobium sp. (EC 1.1.1.2), is involved in the reduction of both biological and exogenous aldehydes and is present in almost all tissues.

HY-P2993B

Isocitrate dehydrogenase (NAD+), Bacteria	Isocitrate Dehydrogenase (IDH)	Others
Isocitrate dehydrogenase (NAD+) , Bacteria (EC 1.1.1.41) is an enzyme that catalyzes the oxidative decarboxylation of Isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2. This is a two-step process, which involves oxidation of Isocitrate (a secondary alcohol) to oxalosuccinate (a ketone) , followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate.

HY-N20617

(2E,6E,10E)-12-Hydroxyfarnesol	Drug Metabolite Endogenous Metabolite Cytochrome P450	Infection
(2E,6E,10E)-12-Hydroxyfarnesol is a metabolite of Farnesol (HY-Y0248A). (2E,6E,10E)-12-Hydroxyfarnesol forms via CYP2E1- and CYP2C19-mediated ω-hydroxylation of Farnesol in mammalian systems, and via CYP2E1-catalyzed selective hydroxylation of Farnesol in mammalian cells. (2E,6E,10E)-12-Hydroxyfarnesol is produced by the endophytic fungus Aspergillus sp. AST0006. When cholesterol synthesis is blocked, (2E,6E,10E)-12-Hydroxyfarnesol acts as a precursor for the formation of α,β-dicarboxylic acid .

HY-W724345

Fomepizole-d2 4-Methylpyrazole-d₂	Isotope-Labeled Compounds Cytochrome P450	Metabolic Disease
Fomepizole-d₂ (4-Methylpyrazole-d₂) is the deuterium labeled Fomepizole (HY-B0876). Fomepizole (4-Methylpyrazole) is a potent cytochrome P450 (CYP2E1) inhibitor. Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole has the potential for an antidote for ethylene glycol or methanol poisoning .

製品番号	製品名	Type

HY-W115789

Sodium silicate	生化学アッセイ試薬
Sodium silicate is a water-soluble silicate. Sodium silicate is widely used as a binder, particularly in the production of detergents, soaps, and cleaners. Sodium silicate promotes the deposition of suberin polyphenols and lignin at wound sites of potato tubers, accelerates callus structure formation, enhances ROS production, and induces the synthesis of total phenols and flavonoids. Sodium silicate reduces the weight loss rate and disease index of wounded potato tubers during storage .

Sodium silicate

生化学アッセイ試薬

Sodium silicate is a water-soluble silicate. Sodium silicate is widely used as a binder, particularly in the production of detergents, soaps, and cleaners. Sodium silicate promotes the deposition of suberin polyphenols and lignin at wound sites of potato tubers, accelerates callus structure formation, enhances ROS production, and induces the synthesis of total phenols and flavonoids. Sodium silicate reduces the weight loss rate and disease index of wounded potato tubers during storage .

HY-W015570

4-Nitrobenzyl alcohol (4-Nitrobenzenemathanol) 4-Nitrobenzenemathanol; 4-Nitrobenzyl alcohol	生化学アッセイ試薬
4-Nitrobenzyl alcohol (4-Nitrobenzenemathanol) is a nitro compound used as a reactant in drug synthesis. 4-Nitrobenzyl alcohol can be catalyzed to 4-nitrobenzaldehyde by the enzyme encoded by the benzyl alcohol dehydrogenase gene (ntnD) .

製品番号	製品名	Target	研究分野

HY-122297A

H-Arg-Phe-OH TFA	ペプチド	Others
H-Arg-Phe-OH TFA is an amphipathic peptide. H-Arg-Phe-OH TFA has the ability to induce native-like protein aggregation. H-Arg-Phe-OH TFA can induce aggregation of the neutral model protein yeast alcohol dehydrogenase (ADH) .

HY-122297

H-Arg-Phe-OH	ペプチド	Others
H-Arg-Phe-OH is an amphipathic peptide. H-Arg-Phe-OH has the ability to induce native-like protein aggregation. H-Arg-Phe-OH can induce aggregation of the neutral model protein yeast alcohol dehydrogenase (ADH) .

製品番号	製品名	Category	Target	構造式

HY-N4067

Isochenodeoxycholic acid isoCDCA	Source Classification	FXR Endogenous Metabolite
Isochenodeoxycholic acid (isoCDCA) is a FXR agonist. Isochenodeoxycholic acid activates the activity of FXR and induces the mRNA expression of FXR target genes (Ostβ and Kng1). Isochenodeoxycholic acid serves as a substrate for the liver class I ADH γγ isozyme-mediated 3β-dehydrogenation reaction .

HY-76006

3-Hydroxybenzaldehyde M-Hydroxybenzaldehyde	Cardiovascular Disease Monophenols Microorganisms other families Classification of Application Fields Ketones, Aldehydes, Acids Phenols Plants Disease Research Fields Source Classification	Aldehyde Dehydrogenase (ALDH) NF-κB p38 MAPK
3-Hydroxybenzaldehyde (3-HBA) is a precursor compound for phenolic compounds like Protocatechuic aldehyde (PCA) (HY-N0295). 3-Hydroxybenzaldehyde, produced by 3-hydroxybenzyl-alcohol dehydrogenase, is a substrate of *aldehyde dehydrogenase* (ALDH)** in rats and humans. 3-Hydroxybenzaldehyde has vasculoprotective effects in vitro and in vivo. 3-Hydroxybenzaldehyde is proming for research of atherosclerosis .

HY-B1229

Isovaleramide 1 Publications Verification 3-Methylbutanamide	Structural Classification 天然物 other families Plants Source Classification	GABA Receptor
Isovaleramide (3-Methylbutanamide) is an orally active anticonvulsant. Isovaleramide inhibits alcohol dehydrogenase (ADH) activity and regulates GABAergic system. Isovaleramide reduces acute kidney injury. Isovaleramide has antiepileptic, anxiolytic, sedative and hypnotic effects[1] .

HY-76228

1H-pyrazole Pyrazole	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Parasite iGluR
1H-pyrazole (Pyrazole) is a five-membered heterocyclic compound, and its derivatives are orally effective antimalarial and antileishmanial agents with the potential to modulate targets such as alcohol dehydrogenase and NMDA receptors. 1H-pyrazole derivatives exhibit inhibitory effects on Plasmodium berghei in infected mice and on promastigotes of Leishmania aethiopica, respectively. 1H-pyrazole can be used in research related to malaria and leishmaniasis .

HY-N1177

Taraxerone	Triterpenes Classification of Application Fields Terpenoids Crassulaceae Astragalus oleifolius DC. Sedum sarmentosum Bunge Plants Compositae Inflammation/Immunology Disease Research Fields Source Classification	Aldehyde Dehydrogenase (ALDH)
Taraxerone is isolated from Sedum sarmentosum. Taraxerone enhances effects on alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities with EC₅₀ values of 512.42 and 500.16 μM, respectively .

HY-33914

4-Hydroxymethylpyrazole	天然物 Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Drug Metabolite
4-Hydroxymethylpyrazole is the primary metabolite of Fomepizole (HY-B0876) produced through hepatic oxidative metabolism. 4-Hydroxymethylpyrazole exhibits a plasma concentration that is positively correlated with the administered dosage of Fomepizole, and it demonstrates a relatively short half-life. 4-Hydroxymethylpyrazole demonstrates inhibitory effects on alcohol dehydrogenase (ADH) in both humans and monkeys, but its inhibition constant is significantly higher than that of Fomepizole, rendering its in vivo impact negligible .

HY-N13031

Bellericagenin A	Terpenoids Combretaceae Plants Pentacyclic Triterpenoids Terminalia bellirica (Gaertn.) Roxb. Source Classification	Bacterial
Bellericagenin A is a pentacyclic triterpenic acid isolated from the bark of Terminalia bellerica. Bellericagenin A exhibits antimicrobial activity. Bellericagenin A exhibits a high affinity to **alcohol dehydrogenase (ADH**), which has the potential for ameliorating the alcoholic liver injury .

HY-76006R

3-Hydroxybenzaldehyde (Standard) M-Hydroxybenzaldehyde (Standard)	Structural Classification Monophenols Microorganisms other families Ketones, Aldehydes, Acids Phenols Plants Source Classification	Reference Standards Aldehyde Dehydrogenase (ALDH) NF-κB p38 MAPK
3-Hydroxybenzaldehyde (Standard) is the analytical standard of 3-Hydroxybenzaldehyde. This product is intended for research and analytical applications. 3-Hydroxybenzaldehyde (3-HBA) is a precursor compound for phenolic compounds like Protocatechuic aldehyde (PCA) (HY-N0295). 3-Hydroxybenzaldehyde, produced by 3-hydroxybenzyl-alcohol dehydrogenase, is a substrate of aldehyde dehydrogenase (ALDH) in rats and humans. 3-Hydroxybenzaldehyde has vasculoprotective effects in vitro and in vivo. 3-Hydroxybenzaldehyde is proming for research of atherosclerosis[1][2][3][4].

HY-76228R

1H-pyrazole (Standard) Pyrazole (Standard)	Alkaloids Structural Classification Other Alkaloids Endogenous metabolite Source Classification	Reference Standards Parasite iGluR
1H-pyrazole (Standard) is the analytical standard of 1H-pyrazole. This product is intended for research and analytical applications. 1H-pyrazole (Pyrazole) is a five-membered heterocyclic compound, and its derivatives are orally effective antimalarial and antileishmanial agents with the potential to modulate targets such as alcohol dehydrogenase and NMDA receptors. 1H-pyrazole derivatives exhibit inhibitory effects on Plasmodium berghei in infected mice and on promastigotes of Leishmania aethiopica, respectively. 1H-pyrazole can be used in research related to malaria and leishmaniasis .

HY-N17378

Camelliquercetiside B	Structural Classification Flavonols Flavonoids Camellia sinensis (L.) O. Ktze. Plants Source Classification Theaceae	Others
Camelliquercetiside B is a natural product. Camelliquercetiside B can be isolated from the leaves of Camellia sinensis. Camelliquercetiside B inhibits alcohol dehydrogenase (Alcohol *dehydrogenase), with an IC₅₀* of 13.7 μM against yeast alcohol dehydrogenase. Camelliquercetiside B exhibits scavenging activity against DPPH free radicals .

HY-33914R

4-Hydroxymethylpyrazole (Standard)	天然物 Endogenous metabolite Source Classification	Drug Metabolite Reference Standards
4-Hydroxymethylpyrazole (Standard) is an analytical standard for 4-Hydroxymethylpyrazole (HY-33914). This product is intended for research and analytical applications. 4-Hydroxymethylpyrazole is the primary metabolite of fomepizole (HY-B0876) via hepatic oxidative metabolism. 4-Hydroxymethylpyrazole exhibits a plasma concentration that is positively correlated with the administered dosage of Fomepizole, and it demonstrates a relatively short half-life. 4-Hydroxymethylpyrazole inhibits alcohol dehydrogenase (ADH) in humans and monkeys, but the inhibition constant is much higher than that of fomepizole and is therefore negligible in vivo

HY-N17379

Camelliquercetiside D	Structural Classification Flavonols Flavonoids Camellia sinensis (L.) O. Ktze. Plants Source Classification Theaceae	Others
Camelliquercetiside D is a natural product. Camelliquercetiside D can be isolated from the leaves of Camellia sinensis. Camelliquercetiside D inhibits **alcohol dehydrogenase, with an IC₅₀ of 41.5 μM against yeast ADH**. Camelliquercetiside D exhibits scavenging activity against DPPH .

HY-N20617

(2E,6E,10E)-12-Hydroxyfarnesol	Structural Classification 天然物 Leguminosae Plants Astragalus lentiginosus Douglas ex Hook. Source Classification	Drug Metabolite Endogenous Metabolite Cytochrome P450
(2E,6E,10E)-12-Hydroxyfarnesol is a metabolite of Farnesol (HY-Y0248A). (2E,6E,10E)-12-Hydroxyfarnesol forms via CYP2E1- and CYP2C19-mediated ω-hydroxylation of Farnesol in mammalian systems, and via CYP2E1-catalyzed selective hydroxylation of Farnesol in mammalian cells. (2E,6E,10E)-12-Hydroxyfarnesol is produced by the endophytic fungus Aspergillus sp. AST0006. When cholesterol synthesis is blocked, (2E,6E,10E)-12-Hydroxyfarnesol acts as a precursor for the formation of α,β-dicarboxylic acid .

製品番号	製品名	構造式

HY-W724345

Fomepizole-d2

Fomepizole-d₂ (4-Methylpyrazole-d₂) is the deuterium labeled Fomepizole (HY-B0876). Fomepizole (4-Methylpyrazole) is a potent cytochrome P450 (CYP2E1) inhibitor. Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole has the potential for an antidote for ethylene glycol or methanol poisoning .

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