(2E,6E,10E)-12-Hydroxyfarnesol
(2E,6E,10E)-12-Hydroxyfarnesol is a metabolite of Farnesol (HY-Y0248A). (2E,6E,10E)-12-Hydroxyfarnesol forms via CYP2E1- and CYP2C19-mediated ω-hydroxylation of Farnesol in mammalian systems, and via CYP2E1-catalyzed selective hydroxylation of Farnesol in mammalian cells. (2E,6E,10E)-12-Hydroxyfarnesol is produced by the endophytic fungus Aspergillus sp. AST0006. When cholesterol synthesis is blocked, (2E,6E,10E)-12-Hydroxyfarnesol acts as a precursor for the formation of α,β-dicarboxylic acid.
For research use only. We do not sell to patients.
- CAS No.: 69809-46-7
- Formula: C15H26O2
- Molecular Weight:238.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
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Fungal Metabolite |
CYP2E1 |
CYP2C19 |
Chemical Information
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CAS No. 69809-46-7
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Molecular Weight 238.37
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Formula C15H26O2
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SMILES
OC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CO
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. DeBarber AE, et al. Omega-hydroxylation of farnesol by mammalian cytochromes p450. Biochim Biophys Acta. 2004 Jun 1;1682(1-3):18-27. [Content Brief]
[2]. de Amorim MR, et al. An epigenetic modifier induces production of 3-(4-oxopyrano)-chromen-2-ones in Aspergillus sp. AST0006, an endophytic fungus of Astragalus lentiginosus. Tetrahedron. 2020 Oct 23;76(43):131525. [Content Brief]
[3]. Lakshman R, et al. Use of CYP2E1-transfected human liver cell lines in elucidating the actions of ethanol. Alcohol Clin Exp Res. 2005;29(9):1726-1734. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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