69809-46-7
Chemical Structure
(2E,6E,10E)-12-Hydroxyfarnesol
- CAS No.: 69809-46-7
- Formula:C15H26O2
- Molecular Weight:238.37
InChIKey: FLIKBVTXNBEPQQ-RDUMTQBOSA-N
SMILES: OC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CO
Biological Activity: (2E,6E,10E)-12-Hydroxyfarnesol is a metabolite of Farnesol (HY-Y0248A). (2E,6E,10E)-12-Hydroxyfarnesol forms via CYP2E1- and CYP2C19-mediated ω-hydroxylation of Farnesol in mammalian systems, and via CYP2E1-catalyzed selective hydroxylation of Farnesol in mammalian cells. (2E,6E,10E)-12-Hydroxyfarnesol is produced by the endophytic fungus Aspergillus sp. AST0006. When cholesterol synthesis is blocked, (2E,6E,10E)-12-Hydroxyfarnesol acts as a precursor for the formation of α,β-dicarboxylic acid[1][2][3].
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(2E,6E,10E)-12-Hydroxyfarnesol | (2E,6E,10E)-12-Hydroxyfarnesol is a metabolite of Farnesol (HY-Y0248A). (2E,6E,10E)-12-Hydroxyfarnesol forms via CYP2E1- and CYP2C19-mediated ω-hydroxylation of Farnesol in mammalian systems, and via CYP2E1-catalyzed selective hydroxylation of Farnesol in mammalian cells. (2E,6E,10E)-12-Hydroxyfarnesol is produced by the endophytic fungus Aspergillus sp. AST0006. When cholesterol synthesis is blocked, (2E,6E,10E)-12-Hydroxyfarnesol acts as a precursor for the formation of α,β-dicarboxylic acid. | |||||||||||||||||||||
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- [1]. DeBarber AE, et al. Omega-hydroxylation of farnesol by mammalian cytochromes p450. Biochim Biophys Acta. 2004 Jun 1;1682(1-3):18-27. [Content Brief]
- [2]. de Amorim MR, et al. An epigenetic modifier induces production of 3-(4-oxopyrano)-chromen-2-ones in Aspergillus sp. AST0006, an endophytic fungus of Astragalus lentiginosus. Tetrahedron. 2020 Oct 23;76(43):131525. [Content Brief]
- [3]. Lakshman R, et al. Use of CYP2E1-transfected human liver cell lines in elucidating the actions of ethanol. Alcohol Clin Exp Res. 2005;29(9):1726-1734. [Content Brief]
Keywords
