1. Neuronal Signaling
  2. Amyloid-β
  3. Frentizole

Frentizole 

Cat. No.: HY-15374 Purity: 99.37%
Handling Instructions

Frentizole, an FDA-approved immunosuppressant, is a Aβ-ABAD (binding alcohol dehydrogenase) interaction inhibitor with an IC50 value of 200 μM. Frentizole is used in studies of diseases related to rheumatoid arthritis and systemic lupus erythematosus.

For research use only. We do not sell to patients.

Frentizole Chemical Structure

Frentizole Chemical Structure

CAS No. : 26130-02-9

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Solution
10 mM * 1 mL in DMSO USD 145 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 145 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 132 In-stock
Estimated Time of Arrival: December 31
10 mg USD 198 In-stock
Estimated Time of Arrival: December 31
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Description

Frentizole, an FDA-approved immunosuppressant, is a Aβ-ABAD (binding alcohol dehydrogenase) interaction inhibitor with an IC50 value of 200 μM. Frentizole is used in studies of diseases related to rheumatoid arthritis and systemic lupus erythematosus[1][2][3].

In Vitro

Frentizole (500 ng/mL, 48 hours) is effective in inhibiting thymidine incorporation into DNA when adds to lymphocyte cultures alongside mitogens, and significantly inhibits the response to concanavalin A by 58% in a dose-dependent manner in lymphocytes extracted from mice peritoneal cavity[1].
Frentizole (62.5 ng/mL) can effectively inhibit uridine incorporation and the inhibition of uridine incorporation is independent of the phytochemical used[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Frentizole (8.2 or 79.9 mg/kg/day for young mice in animal feedings, 52 weeks) can extend the life span of NZB/NZW mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NZB/NZW mice[2]
Dosage: 8.2 or 79.9 mg/kg/day for young mice
Administration: In animal feedings; 52 weeks
Result: Showed that the average lifespan of young untreated mice was 38 weeks, in the low dose group the average lifespan was about 38 weeks, and in the high dose group the lifespan was significantly longer with an average lifespan of about 61 weeks.
Significantly suppressed leukocyte counts, compared to a mean peripheral blood leukocyte count of 4160 in control mice, 3217 in low dose treated mice and 3450 in high dose treated mice.
Significant increased in terminal neutrophil counts in young low and high dose treated mice compared to control.
Molecular Weight

299.35

Formula

C15H13N3O2S

CAS No.
SMILES

O=C(NC1=CC=CC=C1)NC2=NC3=CC=C(OC)C=C3S2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (41.76 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3406 mL 16.7029 mL 33.4057 mL
5 mM 0.6681 mL 3.3406 mL 6.6811 mL
10 mM 0.3341 mL 1.6703 mL 3.3406 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 1.25 mg/mL (4.18 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 1.25 mg/mL (4.18 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Product Name:
Frentizole
Cat. No.:
HY-15374
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