26130-02-9
26130-02-9
Chemical Structure
Frentizole
- CAS No.: 26130-02-9
- Formula:C15H13N3O2S
- Molecular Weight:299.35
IUPAC Name: 1-(6-methoxybenzo[d]thiazol-2-yl)-3-phenylurea
InChIKey: JHBWYQRKOUBPCA-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC=C1)NC2=NC3=CC=C(OC)C=C3S2
Biological Activity: Frentizole, an FDA-approved immunosuppressant, is a Aβ-ABAD (binding alcohol dehydrogenase) interaction inhibitor with an IC50 value of 200 μM. Frentizole is used in studies of diseases related to rheumatoid arthritis and systemic lupus erythematosus[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Frentizole | 98.48% | Frentizole, an FDA-approved immunosuppressant, is a Aβ-ABAD (binding alcohol dehydrogenase) interaction inhibitor with an IC50 value of 200 μM. Frentizole is used in studies of diseases related to rheumatoid arthritis and systemic lupus erythematosus. | ||||||||||||||||||||
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References
- [1]. Meisel AD, et al. Effect of frentizole on mitogen-induced blastogenesis in human lymphocytes. J Immunopharmacol. 1979;1(4):483-95. [Content Brief]
- [2]. Walker SE, et al. Prolonged lifespans in female NZB/NZW mice treated with the experimental immunoregulatory drug frentizole. Arthritis Rheum. 1982 Nov;25(11):1291-7. [Content Brief]
- [3]. Yuli Xie, et al. Identification of small-molecule inhibitors of the Abeta-ABAD interaction. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4657-60. [Content Brief]
Keywords
