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antileukemic+activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (10) Bacterial (1) Bcl-2 Family (2) Biochemical Assay Reagents (1) Caspase (2) CRM1 (1) Cytochrome P450 (1) Deubiquitinase (1) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (3) FLT3 (2) HDAC (2) Histone Demethylase (1) Interleukin Related (1) IRAK (1) JAK (1) Parasite (1) PARP (2) PI3K (1) Pyroptosis (1) Reactive Oxygen Species (ROS) (2) Reference Standards (1) STAT (1)
By Research Areas:	Cancer (24) Infection (2) Inflammation/Immunology (1)
Oligonucleotides:	Antisense Oligonucleotides (1)

Inhibitors & Agonists

Natural
Products

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-109117

Iadademstat 5+ Cited Publications ORY-1001	Histone Demethylase Apoptosis	Cancer
Iadademstat (ORY-1001) is a highly potent, orally active and selective LSD1 (KDM1A) inhibitor with antileukemic activity. Iadademstat can be used for relapsed or refractory acute myeloid leukemia research .

HY-P2970

Stem bromelain	Apoptosis PARP Caspase Bcl-2 Family Bacterial Interleukin Related	Infection Inflammation/Immunology Cancer
Stem bromelain (EC 3.4.22.32) is a cysteine protease and antibacterial agent. Stem bromelain can be isolated from the stem of the pineapple (Ananas comosus). Stem bromelain induces dose-dependent secretion of IL-12p70, and IL-6, induces Apoptosis, causes cleavage of full-length PARP protein, Caspase 3, and Caspase 9, increases Bax, and decreases Bcl-2. Stem bromelain possesses various fibrinolytic, antiedema, antithrombotic, and anti-inflammatory activities. Stem bromelain also exhibits in vivo antitumor and antileukemic activities, as well as antimetastatic effects. Stem bromelain has antimycobacterial activity. Stem bromelain provides protection against lead poisoning .

HY-117996

KPT-251	CRM1 Apoptosis	Cancer
KPT-251 is an orally active chromosome region maintenance 1 protein (CRM1) inhibitor. KPT-251 induces cancer cell apoptosis and shows antileukemic activity .

HY-153495

Prexigebersen BP1001	Bcl-2 Family Apoptosis Reactive Oxygen Species (ROS)	Cancer
Prexigebersen (BP1001) is an antisense oligonucleotide targeting Bcl-2 and Grb2. Prexigebersen exhibits antileukemic activity in cell models. Prexigebersen induces apoptosis (apoptosis), cell cycle arrest and ROS production in leukemia cells. Prexigebersen inhibits Grb2 expression, thereby suppressing tumor growth and survival. Prexigebersen can be used in studies related to acute myeloid leukemia .

HY-U00095

Hepsulfam 2 Publications Verification NCI 329680; ZINC01574758	DNA Alkylator/Crosslinker	Cancer
Hepsulfam (NCI 329680; ZINC01574758) is a anticancer agent that shows excellent antileukemic activity with an median IC₅₀ of 0.91 μg/mL in a panel of different tumors.

HY-111008A

Trimidox hydrochloride VF-233 hydrochloride	DNA/RNA Synthesis	Cancer
Trimidox hydrochloride (VF-233) is a ribonucleotide reductase inhibitor with antileukemic activities. Trimidox hydrochloride inhibits the growth of human promyelocytic leukemia HL-60 cells with an IC₅₀ of 35 μM .

HY-111275

WP-1034	JAK STAT Apoptosis Caspase PARP	Cancer
WP-1034 is a JAK-STAT inhibitor with proapoptotic and antileukemic activity in acute myeloid leukemia (AML). WP-1034 blocks activation of Stat 3 and 5. WP-1034 induces cell cycle arrest and triggers apoptosis. WP-1034 can be used for AML research .

HY-U00095R

Hepsulfam (Standard) NCI 329680 (Standard); ZINC01574758 (Standard)	DNA Alkylator/Crosslinker Reference Standards	Cancer
Hepsulfam (NCI 329680; ZINC01574758) is a anticancer agent that shows excellent antileukemic activity with an median IC50 of 0.91 μg/mL in a panel of different tumors.

HY-115754

S-(N-PhenethylthiocarbaMoyl)-L-cysteine PEITC-Cys	DNA/RNA Synthesis Cytochrome P450	Cancer
S-(N-PhenethylthiocarbaMoyl)-L-cysteine (PEITC-Cys), an anticarcinogenic agent, has antileukemic activity. S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits DNA synthesis in HL60 cells . S-(N-PhenethylthiocarbaMoyl)-L-cysteine is a P450 inhibitor .

HY-160787

NCGC1481	FLT3 IRAK	Cancer
NCGC1481 is an inhibitor of FLT3, IRAK1, and IRAK4, with IC₅₀ values of <0.5 nM, 22.6 nM, and 0.8 nM, respectively. NCGC1481 can effectively overcome the adaptive resistance of leukemia cells to FLT3 inhibitors and has antileukemic activity .

HY-162658

Leuxinostat	HDAC Apoptosis	Cancer
Leuxinostat is an inhibitor for HDAC with IC₅₀ of 30 nM for hHDAC6. Leuxinostat inhibits the proliferation of cells THP1, K562, U937 and MEK1, induces apoptosis in leukemia cells NB4 and MOLT-4. Leuxinostat inhibits the expansion of hematopoietic stem cells and exhibits antileukemic activity in zebrafish models .

HY-N7549

Dehydrobruceantin	Others	Cancer
Dehydrobruceantin has potential antileukemic activity .

HY-N3171A

(+)-Nortrachelogenin Wikstromol	Apoptosis PI3K	Cancer
(+)-Nortrachelogenin (Wikstromol), a pharmacologically ligand from from wikstroemia indica, possesses antileukemic activity .

HY-135771

Avarone (+)-Avarone	Others	Cancer
Avarone ((+)-Avarone) is a sesquiterpenoidal quinone that can be isolated from Dysidea avara. Avarone shows cytotoxicity. Avarone shows antileukemic activity .

HY-111008

Trimidox VF-233	DNA/RNA Synthesis	Cancer
Trimidox (VF-233) is a ribonucleotide reductase inhibitor with antileukemic activities. Trimidox inhibits the growth of human promyelocytic leukemia HL-60 cells with an IC₅₀ of 35 μM .

HY-N14180

6-Deoxyilludin M	Antibiotic	Infection Cancer
6-Deoxyilludin M is an antitumor antibiotic possessing antileukemic activity. 6-Deoxyilludin M can be isolated from the culture broth of the Basidiomycota Pleurotus japonicas .

HY-123718

6-Benzylthioinosine	Parasite	Others
6-Benzylthioinosine is a compound with antileukemic activity that increases cytotoxicity against acute myeloid leukemia cells when combined with metformin, modulating cellular metabolism and signaling pathways through multiple mechanisms.

HY-151897

HDAC-IN-49	HDAC	Cancer
HDAC-IN-49 is a potent unselective HDAC (HDAC) inhibitor with IC₅₀s of 13 nM, 14 nM, 21 nM, 1880 nM, and 10 nM for HDAC1, HDAC2, HDAC3, HDAC4, and HDAC6. HDAC-IN-49 demonstrates prominent antileukemic activity with low cytotoxic activity toward healthy cells .

HY-N12641

Ardisianone	Apoptosis Pyroptosis	Cancer
Ardisianone is a component with an alkyl benzoquinone structure that can be isolated from Ardisia virens Kurz and Ardisia compressa tea extract. Ardisianone exhibits potent antileukemic activity, particularly against HL-60 cells, with IC₅₀ values of 1.87 μM (24 h) and 1.67 μM (48 h). Ardisianone induces caspase-dependent apoptosis and triggers pyroptosis. Ardisianone can be used for the study of acute myeloid leukemia (AML) .

HY-170640

FLT3-IN-29	FLT3 Reactive Oxygen Species (ROS) Apoptosis	Cancer
FLT3-IN-29 (Compound MY-10) is a FLT3 inhibitor (IC₅₀s: 6.5 and 10.3 nM for FLT3-ITD and FLT3-D835Y mutants). FLT3-IN-29 arrests cell cycle at the G0/G1 phase and efficiently induces Apoptosis. FLT3-IN-29 also reduces reactive oxygen species (ROS) production and mitochondrial membrane potential (MMP). FLT3-IN-29 displays antileukemic activity .

HY-126205

Deacetyleupaserrin	Others	Cancer
Deacetyleupaserrin is a sesquiterpenoid with antileukemic activity that can be isolated from Eupatorium semiserratum .

HY-117237

Hisphen MD 1	Biochemical Assay Reagents	Cancer
Hisphen is a chemical mutagen that can affect the grain protein content . Hisphen also has antileukemic activities .

HY-N18237

Bruceanol A	Others	Cancer
Bruceanol A is an antileukemic quassinoid glycoside isolated from Brucea javanica. Bruceanol A exhibits antileukemic activity against P-388 lymphocytic leukemia in vivo. Bruceanol A can be used in studies related to P-388 lymphocytic leukemia .

HY-183689

OAT-4828	Deubiquitinase	Cancer
OAT-4828 is an orally active ubiquitin-specific protease 7 (USP7) inhibitor with an IC₅₀ of 32 nM. OAT-4828 induces antileukemic activity in B-cell-derived non-Hodgkin's lymphoma models via inhibition of USP7. OAT-4828 is applicable to research related to chronic lymphocytic leukemia .

HY-124693

DB1055	Apoptosis	Cancer
DB1055 is a HOXA9 inhibitor that competes with HOXA9 binding to DNA (blocking its DNA interaction activity). DB1055 induces in vitro cell growth reduction, cell apoptosis, and differentiation in human acute myeloid leukemia (AML) cells. DB1055 leads to monocyte-to-macrophage differentiation and exhibits antileukemic activities in a human THP-1 AML in vivo model. DB1055 does not impact human CD34⁺ bone marrow cells. DB1055 can be used for the research of acute myeloid leukemia^[1].

Stem bromelain	Ananas comosus(L.) Merr. Structural Classification Natural Products Classification of Application Fields Bromeliaceae Plants Inflammation/Immunology Disease Research Fields Cancer	Apoptosis PARP Caspase Bcl-2 Family Bacterial Interleukin Related
Stem bromelain (EC 3.4.22.32) is a cysteine protease and antibacterial agent. Stem bromelain can be isolated from the stem of the pineapple (Ananas comosus). Stem bromelain induces dose-dependent secretion of IL-12p70, and IL-6, induces Apoptosis, causes cleavage of full-length PARP protein, Caspase 3, and Caspase 9, increases Bax, and decreases Bcl-2. Stem bromelain possesses various fibrinolytic, antiedema, antithrombotic, and anti-inflammatory activities. Stem bromelain also exhibits in vivo antitumor and antileukemic activities, as well as antimetastatic effects. Stem bromelain has antimycobacterial activity. Stem bromelain provides protection against lead poisoning .

Dehydrobruceantin	Triterpenes Simaroubaceae Brucea antidysenterica J.F.Mill. Terpenoids Plants Source Classification	Others
Dehydrobruceantin has potential antileukemic activity .

(+)-Nortrachelogenin Wikstromol	Natural Products Classification of Application Fields Thymelaeaceae Phenols Polyphenols Plants Disease Research Fields Source Classification Wikstroemia indica Cancer	Apoptosis PI3K
(+)-Nortrachelogenin (Wikstromol), a pharmacologically ligand from from wikstroemia indica, possesses antileukemic activity .

Avarone (+)-Avarone	Quinones Structural Classification Terpenoids Sesquiterpenes Marine natural products Benzene Quinones Source Classification	Others
Avarone ((+)-Avarone) is a sesquiterpenoidal quinone that can be isolated from Dysidea avara. Avarone shows cytotoxicity. Avarone shows antileukemic activity .

6-Deoxyilludin M	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic
6-Deoxyilludin M is an antitumor antibiotic possessing antileukemic activity. 6-Deoxyilludin M can be isolated from the culture broth of the Basidiomycota Pleurotus japonicas .

Ardisianone	Quinones Benzene Quinones Plants Primulaceae Source Classification	Apoptosis Pyroptosis
Ardisianone is a component with an alkyl benzoquinone structure that can be isolated from Ardisia virens Kurz and Ardisia compressa tea extract. Ardisianone exhibits potent antileukemic activity, particularly against HL-60 cells, with IC₅₀ values of 1.87 μM (24 h) and 1.67 μM (48 h). Ardisianone induces caspase-dependent apoptosis and triggers pyroptosis. Ardisianone can be used for the study of acute myeloid leukemia (AML) .

Deacetyleupaserrin	Eupatorium semiserratum DC. Terpenoids Sesquiterpenes Asteraceae Plants Source Classification	Others
Deacetyleupaserrin is a sesquiterpenoid with antileukemic activity that can be isolated from Eupatorium semiserratum .

Bruceanol A	Triterpenes Structural Classification Simaroubaceae Brucea antidysenterica J.F.Mill. Terpenoids Plants Source Classification	Others
Bruceanol A is an antileukemic quassinoid glycoside isolated from Brucea javanica. Bruceanol A exhibits antileukemic activity against P-388 lymphocytic leukemia in vivo. Bruceanol A can be used in studies related to P-388 lymphocytic leukemia .

Cat. No.	Product Name		Classification

HY-153495

Prexigebersen BP1001		Antisense Oligonucleotides
Prexigebersen (BP1001) is an antisense oligonucleotide targeting Bcl-2 and Grb2. Prexigebersen exhibits antileukemic activity in cell models. Prexigebersen induces apoptosis (apoptosis), cell cycle arrest and ROS production in leukemia cells. Prexigebersen inhibits Grb2 expression, thereby suppressing tumor growth and survival. Prexigebersen can be used in studies related to acute myeloid leukemia .

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antileukemic+activity

Inhibitors & Agonists

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Oligonucleotides

Natural
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