FLT3-IN-29
FLT3-IN-29 (Compound MY-10) is a FLT3 inhibitor (IC50s: 6.5 and 10.3 nM for FLT3-ITD and FLT3-D835Y mutants). FLT3-IN-29 arrests cell cycle at the G0/G1 phase and efficiently induces Apoptosis. FLT3-IN-29 also reduces reactive oxygen species (ROS) production and mitochondrial membrane potential (MMP). FLT3-IN-29 displays antileukemic activity.
For research use only. We do not sell to patients.
- Formula: C25H30N6O2
- Molecular Weight:446.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
FLT3-IN-29 shows good antiproliferative activity against MV4-11 cells (IC50 = 0.59 μM)[1].
FLT3-IN-29 (0.2-10 μM, 24 h) arrests cell cycle at the G0/G1 phase, induces•apoptosis, and reduces ROS levels in MV4-11 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 446.54
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Formula C25H30N6O2
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SMILES
CC(C)N1CCC(NC2=NC(NC3=CC=C(OC4=CC=CC=C4)C=C3)=C(C(N)=O)C=N2)CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FLT3-IN-29 Related Classifications
HY-170640 Related Classifications
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