Prexigebersen
Prexigebersen (BP1001) is an antisense oligonucleotide targeting Bcl-2 and Grb2. Prexigebersen exhibits antileukemic activity in cell models. Prexigebersen induces apoptosis (apoptosis), cell cycle arrest and ROS production in leukemia cells. Prexigebersen inhibits Grb2 expression, thereby suppressing tumor growth and survival. Prexigebersen can be used in studies related to acute myeloid leukemia.
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- No. CAS: 202484-91-1
- Peso molecular:5520.57
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
Actividad biológica
Descripciòn
In Vitro
Prexigebersen (3-20 μM; 24 h) induces apoptosis, G0/G1 phase cell cycle arrest, ROS production, mitochondrial membrane depolarization, and growth inhibition in Kasumi-1, Molm-13, MV-4-11 leukemia cell lines and primary AML cells, with an IC50 of 8.479 μM for growth inhibition, and decreases GRB2 and ERK expression in leukemia cell lines[1].
Prexigebersen enhances the inhibitory effects of Decitabine, or Decitabine plus venetoclax, against AML cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Kasumi-1, Molm-13, MV-4-11 leukemia cell lines
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Concentration:3 μM
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Incubation Time:24 h
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Result:Induced apoptosis
- RNA extraction experimental
- Annexin V plus membrane-impermeant dye apoptosis staining
- BrdU Incorporation Assay
- ROS/oxidative-stress fluorescent staining
- Patient-Derived Orthotopic Xenograft (PDOX)
- Protocol for Cell Cycle
- Directly Induced Neuron Culture
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Flow cytometric DNA-content cell-cycle staining
- Patient-Derived Xenograft (PDX)
- Apoptosis Solutions
- Subcutaneous Cell-Line-Derived Xenograft
- Orthotopic Cell-Line Xenograft
Chemical Information
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No. CAS 202484-91-1
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Peso molecular 5520.57
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SMILES
[Prexigebersen]
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Synonyms
BP1001
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)