S-(N-PhenethylthiocarbaMoyl)-L-cysteine  (Synonyms: PEITC-Cys)

S-(N-PhenethylthiocarbaMoyl)-L-cysteine (PEITC-Cys), an anticarcinogenic agent, has antileukemic activity. S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits DNA synthesis in HL60 cells^[1]. S-(N-PhenethylthiocarbaMoyl)-L-cysteine is a P450 inhibitor^[2].

DNA Synthesis^[1]; P450^[2]

S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits cell growth of HL60 cell (GC₅₀=336 nM)^[1].
S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits DNA synthesis in HL60 cells (IC₅₀=6.47 μM)^[1].
S-(N-PhenethylthiocarbaMoyl)-L-cysteine induced DNA fragmentation in HL 60 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

284.40

C₁₂H₁₆N₂O₂S₂

53330-02-2

N[C@@H](CSC(NCCC1=CC=CC=C1)=S)C(O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Adesida A, Edwards LG, Thornalley PJ. Inhibition of human leukaemia 60 cell growth by mercapturic acid metabolites of phenylethyl isothiocyanate. Food Chem Toxicol. 1996 Apr;34(4):385-92.  [Content Brief]

  [2]. Conaway CC, et al. Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes. Chem Res Toxicol. 2001 Sep;14(9):1170-6.  [Content Brief]