1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. DNA/RNA Synthesis
    Cytochrome P450
  3. S-(N-PhenethylthiocarbaMoyl)-L-cysteine

S-(N-PhenethylthiocarbaMoyl)-L-cysteine (Synonyms: PEITC-Cys)

Cat. No.: HY-115754
Handling Instructions

S-(N-PhenethylthiocarbaMoyl)-L-cysteine (PEITC-Cys), an anticarcinogenic agent, has antileukemic activity. S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits DNA synthesis in HL60 cells. S-(N-PhenethylthiocarbaMoyl)-L-cysteine is a P450 inhibitor.

For research use only. We do not sell to patients.

S-(N-PhenethylthiocarbaMoyl)-L-cysteine Chemical Structure

S-(N-PhenethylthiocarbaMoyl)-L-cysteine Chemical Structure

CAS No. : 53330-02-2

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Description

S-(N-PhenethylthiocarbaMoyl)-L-cysteine (PEITC-Cys), an anticarcinogenic agent, has antileukemic activity. S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits DNA synthesis in HL60 cells[1]. S-(N-PhenethylthiocarbaMoyl)-L-cysteine is a P450 inhibitor[2].

IC50 & Target

DNA Synthesis[1]; P450[2]

In Vitro

S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits cell growth of HL60 cell (GC50=336 nM)[1].
S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits DNA synthesis in HL60 cells (IC50=6.47 μM)[1].
S-(N-PhenethylthiocarbaMoyl)-L-cysteine induced DNA fragmentation in HL 60 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: HL60 cells
Concentration: 0.1-10 μM
Incubation Time: 48 hours
Result: Inhibited the cell growth with a GC50 value of 336 nM.

Cell Proliferation Assay[1]

Cell Line: HL60 cells
Concentration: 4 μM
Incubation Time: 0, 20, 40, 60, 80, 100 hours
Result: Inhibited the cell growth.
Molecular Weight

284.40

Formula

C₁₂H₁₆N₂O₂S₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
S-(N-PhenethylthiocarbaMoyl)-L-cysteine
Cat. No.:
HY-115754
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