S-(N-PhenethylthiocarbaMoyl)-L-cysteine
S-(N-PhenethylthiocarbaMoyl)-L-cysteine (PEITC-Cys), an anticarcinogenic agent, has antileukemic activity. S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits DNA synthesis in HL60 cells. S-(N-PhenethylthiocarbaMoyl)-L-cysteine is a P450 inhibitor.
For research use only. We do not sell to patients.
- CAS No.: 53330-02-2
- Formula: C12H16N2O2S2
- Molecular Weight:284.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
Description
IC50 & Target
In Vitro
S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits cell growth of HL60 cell (GC50=336 nM)[1].
S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits DNA synthesis in HL60 cells (IC50=6.47 μM)[1].
S-(N-PhenethylthiocarbaMoyl)-L-cysteine induced DNA fragmentation in HL 60 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HL60 cells
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Concentration:0.1-10 μM
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Incubation Time:48 hours
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Result:Inhibited the cell growth with a GC50 value of 336 nM.
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Cell Line:HL60 cells
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Concentration:4 μM
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Incubation Time:0, 20, 40, 60, 80, 100 hours
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Result:Inhibited the cell growth.
Chemical Information
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CAS No. 53330-02-2
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Molecular Weight 284.40
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Formula C12H16N2O2S2
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SMILES
N[C@@H](CSC(NCCC1=CC=CC=C1)=S)C(O)=O
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Synonyms
PEITC-Cys
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Adesida A, Edwards LG, Thornalley PJ. Inhibition of human leukaemia 60 cell growth by mercapturic acid metabolites of phenylethyl isothiocyanate. Food Chem Toxicol. 1996 Apr;34(4):385-92. [Content Brief]
[2]. Conaway CC, et al. Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes. Chem Res Toxicol. 2001 Sep;14(9):1170-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
S-(N-PhenethylthiocarbaMoyl)-L-cysteine Related Classifications
HY-115754 Related Classifications
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