53330-02-2
53330-02-2
Chemical Structure
S-(N-PhenethylthiocarbaMoyl)-L-cysteine
Synonym(s): PEITC-Cys
- CAS No.: 53330-02-2
- Formula:C12H16N2O2S2
- Molecular Weight:284.40
IUPAC Name: S-(phenethylcarbamothioyl)-L-cysteine
InChIKey: FWNOABWJBHBVKJ-JTQLQIEISA-N
SMILES: N[C@@H](CSC(NCCC1=CC=CC=C1)=S)C(O)=O
Biological Activity: S-(N-PhenethylthiocarbaMoyl)-L-cysteine (PEITC-Cys), an anticarcinogenic agent, has antileukemic activity. S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits DNA synthesis in HL60 cells[1]. S-(N-PhenethylthiocarbaMoyl)-L-cysteine is a P450 inhibitor[2].
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S-(N-PhenethylthiocarbaMoyl)-L-cysteine | S-(N-PhenethylthiocarbaMoyl)-L-cysteine (PEITC-Cys), an anticarcinogenic agent, has antileukemic activity. S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits DNA synthesis in HL60 cells. S-(N-PhenethylthiocarbaMoyl)-L-cysteine is a P450 inhibitor. | |||||||||||||||||||||
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References
- [1]. Adesida A, Edwards LG, Thornalley PJ. Inhibition of human leukaemia 60 cell growth by mercapturic acid metabolites of phenylethyl isothiocyanate. Food Chem Toxicol. 1996 Apr;34(4):385-92. [Content Brief]
- [2]. Conaway CC, et al. Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes. Chem Res Toxicol. 2001 Sep;14(9):1170-6. [Content Brief]
