Ardisianone
Ardisianone is a component with an alkyl benzoquinone structure that can be isolated from Ardisia virens Kurz and Ardisia compressa tea extract. Ardisianone exhibits potent antileukemic activity, particularly against HL-60 cells, with IC50 values of 1.87 μM (24 h) and 1.67 μM (48 h). Ardisianone induces caspase-dependent apoptosis and triggers pyroptosis. Ardisianone can be used for the study of acute myeloid leukemia (AML).
For research use only. We do not sell to patients.
- CAS No.: 66398-68-3
- Formula: C24H38O5
- Molecular Weight:406.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Ardisianone (1-5 μM, 24-48 h) induces apoptosis and shows potent cytotoxic activity against HL-60 cells, with IC50 values of 1.87 μM (24 h) and 1.67 μM (48 h)[1].
Ardisianone (2-5 μM, 24 h) exerts pyroptosis-inducing activity in HL-60 cells[1].
Ardisianone (0.5-2 μM, 72 h) significantly increases CD11b expression and CD68 expression, and induces differentiation into monocyte-like and macrophage-like morphologies in HL-60 cells[1].
Ardisianone (2 μM) shows DNA damage-inducing activity in HL-60 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HL-60 cells
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Concentration:1, 2, 3, 4, 5 μM
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Incubation Time:3, 6, 9, 12, 15, 24 h
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Result:Induced apoptosis in HL-60 cells and concentration-dependent elevation of sub-G1 apoptotic population.
Induced profound degradation of DFF45/ICAD.
Upregulated death receptors (especially TNFR2).
Downregulated IAPs (cIAP1, cIAP2, survivin).
Promoted time-dependent activation of caspase-8/-3 and degradation of Bid.
Chemical Information
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CAS No. 66398-68-3
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Molecular Weight 406.56
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Formula C24H38O5
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SMILES
CCCCCCCCCCCCC[C@@H](OC(C)=O)CC(C(C(OC)=C1)=O)=CC1=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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