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chalcone derivatives

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-121054
    Chalcone
    1 Publications Verification

    (E/Z)-Benzylideneacetophenone

    		 Bacterial Parasite Inflammation/Immunology Cancer
    Chalcone is isolated from Glycyrrhiza uralensis and used to synthesize chalcone derivatives. Chalcone derivatives possess varied biological and pharmacological activity, including anti-inflammatory, antioxidative, antibacterial, anticancer, and anti-parasitic activities .
    Chalcone
  • HY-Y0232
    Meldrum's acid

    2,2-Dimethyl-1,3-dioxane-4,6-dione

    		 Biochemical Assay Reagents Others
    Meldrum's acid (2,2-Dimethyl-1,3-dioxane-4,6-dione) is a nucleophilic reagent. Meldrum's acid participates in Michael addition reactions. Meldrum's acid can be used in asymmetric organocatalysis .
    Meldrum's acid
  • HY-W002251
    Benzo[b]thiophene-3-carbaldehyde

    		Biochemical Assay Reagents Others
    Benzo[b]thiophene-3-carbaldehyde is a 3-formyl-substituted benzo[b]thiophene derivative that acts as an oxidizable substrate to convert to benzo[b]thiophene-3-carboxylic acid under liquid-phase conditions. Compared with analogs such as benzaldehyde and thiophene-2-carbaldehyde, Benzo[b]thiophene-3-carbaldehyde has lower oxidation difficulty, and can significantly increase the reaction rate in the presence of initiators (such as Na +Br - or DBA). Benzo[b]thiophene-3-carbaldehyde also serves as a key starting material for the synthesis of compounds including heteroaryl chalcones .
    Benzo[b]thiophene-3-carbaldehyde
  • HY-W082785A
    L6H21
    1 Publications Verification

    		 TNF Receptor Interleukin Related Toll-like Receptor (TLR) NF-κB NOD-like Receptor (NLR) Apoptosis Caspase Bcl-2 Family Reactive Oxygen Species (ROS) Neurological Disease Metabolic Disease Inflammation/Immunology
    L6H21, a Chalcone (HY-121054) derivative, is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor. L6H21 directly binds to MD-2 protein with a high affinity and low KD value of 33.3 μM, blocking the formation of the LPS-TLR4/MD-2 complex. L6H21 inhibits LPS-induced expression of TNF-α and IL-6 in RAW264.7 macrophages, with IC50 values of 6.58 and 8.59 μM, respectively. L6H21 can be used for alcoholic liver disease, metabolic disturbance and neuroinflammation research .
    L6H21
  • HY-N7516
    4'-Hydroxy-2,4-dimethoxychalcone

    		Parasite Bacterial Fungal Infection
    4'-Hydroxy-2,4-dimethoxychalcone is a natural chalcone derivatives in the red herbal resin of Dracaena cochinchinensis. 4'-Hydroxy-2,4-dimethoxychalcone displays a wide range of biological activities including antimalarial, antiprotozoal, antibacterial, antifungal activity .
    4'-Hydroxy-2,4-dimethoxychalcone
  • HY-107412
    Proteasome inhibitor IX

    PS-IX; AM114

    		 Proteasome Cancer
    Proteasome inhibitor IX (PS-IX; AM114) is a Chalcone derivative and a chymotrypsin-like activity of the 20S proteasome inhibitor with an IC50 value of ~1 μM. Proteasome inhibitor IX exhibits HCT116 p53 +/+ cells growth inhibitory activity with an IC50 value of 1.49 μM. Proteasome inhibitor IX has potent anticancer activity .
    Proteasome inhibitor IX
  • HY-N10917
    Xanthohumol I

    		Drug Derivative Infection Cancer
    Xanthohumol I is a derivative of Chalcone (HY-121054) that can be isolated from Humulus lupulus L. (hops). Xanthohumol I exhibits free radical scavenging activity .
    Xanthohumol I
  • HY-145104
    Antioxidant agent-1

    		Drug Derivative Others
    Antioxidant agent-1 is a new chalcone derivative as a potential antioxidant agent.
    Antioxidant agent-1
  • HY-W012349
    2′-Hydroxychalcone

    		NF-κB Fungal Apoptosis Autophagy Infection Cancer
    2′-Hydroxychalcone is a hydroxyl derivative of chalcones with anticancer activities. 2'-Hydroxychalcone inhibits NF-κB pathway and induces autophagy and apoptosis in breast cancer cells . 2′-Hydroxychalcone shows a better antifungal activity against the complex Paracoccidioides spp .
    2′-Hydroxychalcone
  • HY-148568
    TMV-IN-2

    		TMV Bacterial Infection Inflammation/Immunology Cancer
    TMV-IN-2, chalcone derivative, is a tobacco mosaic virus (TMV) inhibitor. TMV-IN-2 has antiviral activity against TMV with an EC50 value of 89.9 μg/mL. TMV-IN-2 can be used for the research of infection, inflammation and tumor .
    TMV-IN-2
  • HY-W325160
    4-Chlorochalcone

    		Monoamine Oxidase Cholinesterase (ChE) Others
    4-Chlorochalcone (Compound 3) is a monoamine oxidase inhibitor (hMAO-B: IC50 = 0.082 μM, hMAO-A: IC50 = 9.95 μM). 4-Chlorochalcone also exhibits inhibitory activity against cholinesterase (AChE: IC50 = 2.79 μM). 4-Chlorochalcone is a chalcone derivative .
    4-Chlorochalcone
  • HY-156090
    PK-10

    		Mitochondrial Metabolism Fungal Infection
    PK-10 is a synergistic antibacterial agent of Fluconazole (HY-B0101) and has strong antifungal activity against a variety of Fluconazole-resistant Candida albicans strains. PK-10 combined with Fluconazole can inhibit hyphae formation and induce the accumulation of reactive oxygen species. It further causes damage to mitochondrial membrane potential, reduces intracellular ATP content, and leads to mitochondrial dysfunction .
    PK-10
  • HY-148569
    TMV-IN-3

    		TMV Bacterial Infection Inflammation/Immunology Cancer
    TMV-IN-3, chalcone derivative, is a tobacco mosaic virus (TMV) inhibitor. TMV-IN-3 has antiviral activity against TMV with an EC50 value of 120.3 μg/mL. TMV-IN-3 can be used for the research of infection, inflammation and tumor .
    TMV-IN-3
  • HY-148567
    TMV-IN-1

    		TMV Bacterial Infection Inflammation/Immunology Cancer
    TMV-IN-1, chalcone derivative, is a tobacco mosaic virus (TMV) inhibitor. TMV-IN-1 has good therapeutic activity and protective activity against TMV with EC50 values of 70.7 μg/mL and 60.8 μg/mL, respectively. TMV-IN-1 can be used for the research of infection, inflammation and tumor .
    TMV-IN-1
  • HY-121054R
    Chalcone (Standard)

    (E/Z)-Benzylideneacetophenone (Standard)

    		 Bacterial Parasite Reference Standards Inflammation/Immunology Cancer
    Chalcone (Standard) is the analytical standard of Chalcone. This product is intended for research and analytical applications. Chalcone is isolated from Glycyrrhiza uralensis and used to synthesize chalcone derivatives. Chalcone derivatives possess varied biological and pharmacological activity, including anti-inflammatory, antioxidative, antibacterial, anticancer, and anti-parasitic activities .
    Chalcone (Standard)
  • HY-W300403A
    Cinfenoac disodium

    		Drug Derivative Inflammation/Immunology
    Cinfenoac disodium is a chalcone derivative with anti-inflammatory activity and can be used in the study of allergic diseases.
    Cinfenoac disodium
  • HY-145858
    Chalcones A-N-5

    		Ferroptosis Cancer
    Chalcones A-N-5 is a trihydroxy chalcone derivative compound. Chalcones A-N-5 doesn’t show cytotoxicity at the concentration lower than 100 µM (with IC50 > 1 mM), but has a significant effect on promoting cell proliferation. Chalcones A-N-5 potentially promotes neuronal cell growth in the damaged brain tissue. Chalcones A-N-5 also inhibits ferroptosis induced by RSL or erastin and reduces the lipid peroxidation levels induced by Aβ1-42 protein aggregation. Chalcones A-N-5 is a promising molecular skeleton candidate for further development of lead compound for in vivo test to research AD .
    Chalcones A-N-5
  • HY-170977
    JAK1/STAT3-IN-1

    		JAK STAT Inflammation/Immunology
    JAK1/STAT3-IN-1 (compound 4f) is an anti-AD (atopic dermatitis) agent by inhibiting JAK1/STAT3 signaling pathway. JAK1/STAT3-IN-1 inhibits NO generation with an IC50 of 2.17 μM. JAK1/STAT3-IN-1 improves the skin condition of AD-like mice, reduces inflammatory infiltration, inhibits the expressions of p-JAK1/JAK1 and p-STAT3/STAT3, and mitigates the excessive immune response on Calcipotriol (HY-10001) (MC903)-induced AD-like mice .
    JAK1/STAT3-IN-1
  • HY-137831
    TLBC

    		Apoptosis Cancer
    TLBC, a boronic-chalcone derivative, shows a dose-dependent inhibition with IC50 values of 5.5-25.5 μM in various glioma cell lines. TLBC induces apoptosis independent of changes to the tumor suppressor p53 .
    TLBC
  • HY-N7557
    (E)-2'-Hydroxy-3,4-dimethoxychalcone

    		Drug Derivative Cancer
    (E)-2'-Hydroxy-3,4-dimethoxychalcone (compound 7) is a Chalcone derivative with orally active. (E)-2'-Hydroxy-3,4-dimethoxychalcone has anti-tumour activities .
    (E)-2'-Hydroxy-3,4-dimethoxychalcone
  • HY-161144
    AKT-IN-21

    		Akt Apoptosis Cancer
    AKT-IN-21 (compound C36) is a potent AKT inhibitor with broad-spectrum cytotoxicity and anticancer activity. AKT-IN-21 also blocks the cell cycle and induces apoptosis of cancer cells by down-regulating the PI3K/AKT pathway .
    AKT-IN-21
  • HY-164361
    2′-Hydroxy-2,3-dimethoxychalcone

    		NO Synthase Inflammation/Immunology
    α-Gracinoic acid is a Chalcone (HY-121054) derivative with anti-inflammatory activity. α-Gracinoic acid inhibits nitric oxide production catalyzed by inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-treated RAW 264.7 cells .
    2′-Hydroxy-2,3-dimethoxychalcone
  • HY-124345
    2-Trifluoromethyl-2'-methoxychalcone

    		Keap1-Nrf2 Inflammation/Immunology
    2-Trifluoromethyl-2'-methoxychalcone is a chalcone derivative. 2-Trifluoromethyl-2'-methoxychalcone is a potent Nrf2 activator. 2-Trifluoromethyl-2'-methoxychalcone can be used for oxidative stress and inflammation related diseases research .
    2-Trifluoromethyl-2'-methoxychalcone
  • HY-156288
    Anti-Influenza agent 5

    		Influenza Virus Infection
    Anti-Influenza agent 5 (Compound IIB-2), chalcone-like derivative, is an influenza nuclear export inhibitor. Anti-Influenza agent 5 has inhibitory effects on oseltamivir-resistant strains. Anti-Influenza agent 5 can impede virus proliferation by blocking the export of influenza virus nucleoprotein .
    Anti-Influenza agent 5
  • HY-157992
    LM-021

    		Interleukin Related Caspase Lactate Dehydrogenase Reactive Oxygen Species (ROS) Neurological Disease Inflammation/Immunology
    LM-021 is a coumarin-chalcone derivative with anti-aggregatory, antioxidant, neuroprotective and anti-inflammatory properties which suppresses nitric oxide (NO), IL-1β, IL-6, TNF-α production, CD68 antigen (CD68) and histocompatibility-2 (MHCII) expression. LM-021 also attenuates the increase of caspase 1 activity, lactate dehydrogenase release and ROS level. LM-021 can be used for neurological research .
    LM-021
  • HY-171448
    SU-740

    		Others Inflammation/Immunology
    SU-740 is a chalcone derivative with anti-ulcer activity .
    SU-740
  • HY-181637
    4-DMA-3'-OH-Chalcone

    		Drug Derivative Endocrinology
    4-DMA-3'-OH-Chalcone (compound 24) is a synthetic chalcone derivative and selective cytotoxic agent.4-DMA-3'-OH-Chalcone reduces viability of endometriotic cells, while preserving or enhancing viability of eutopic endometrial cells.4-DMA-3'-OH-Chalcone can be used for the research of endometriosis .
    4-DMA-3'-OH-Chalcone
  • HY-N10077
    Eriosemation

    Lupichromone

    		 Others Others
    Eriosemation is a chromone derivatives that can be isolated from Flemingia philippinensis .
    Eriosemation
  • HY-N18765
    Dragons blood extract

    		Bacterial Infection Inflammation/Immunology
    Dragons blood extract contains a variety of bioactive compounds, including alkaloids, flavonoids, phenolic acids, and chalcone derivatives, which have antibacterial, anti-inflammatory, antioxidant, and wound-healing effects.
    Dragons blood extract
  • HY-182371
    BRD4 ligand 15

    		Epigenetic Reader Domain Ligands for Target Protein for PROTAC Others
    BRD4 ligand 15 (compound 5) is a BRD4 ligand and alkyne-modified chalcone derivative, which serves as a building block for the synthesis of BRD4-targeting PROTAC TKP-5 (HY-182370) .
    BRD4 ligand 15
  • HY-183934
    Anti-inflammatory agent 99

    		NF-κB JNK ERK p38 MAPK TNF Receptor Interleukin Related Inflammation/Immunology
    Anti-inflammatory agent 99 is a chalcone derivative. Anti-inflammatory agent 99 inhibits LPS (HY-D1056)-induced NF-κB nuclear translocation and suppress the phosphorylation of JNK, ERK, and p38. Anti-inflammatory agent 99 inhibits the expression of cytoinflammatory factors such as TNF-α and IL-6 induced by LPS. Anti-inflammatory agent 99 can be used for the research of LPS-induced septic shock .
    Anti-inflammatory agent 99
  • HY-179481
    Ferroptosis inducer-13

    		Ferroptosis Keap1-Nrf2 Glutathione Peroxidase Reactive Oxygen Species (ROS) Cancer
    Ferroptosis inducer-13 is a 5′-prenylated chalcone derivative that effectively induces ferroptosis in human non-small cell lung cancer (NSCLC) cells by altering the activity of the Nrf2/xCT/GPX4 pathway. Ferroptosis inducer-13 exhibits potent anti-proliferative effects in vitro, and inhibits tumour growth in a NSCLC mouse model. Ferroptosis inducer-13 can be used for NSCLC research .
    Ferroptosis inducer-13
  • HY-107412R
    Proteasome inhibitor IX (Standard)

    PS-IX (Standard); AM114 (Standard)

    		 Reference Standards Proteasome Cancer
    Proteasome inhibitor IX (Standard) is the analytical standard of Proteasome inhibitor IX (HY-107412). This product is intended for research and analytical applications. Proteasome inhibitor IX (PS-IX; AM114) is a Chalcone derivative and a chymotrypsin-like activity of the 20S proteasome inhibitor with an IC50 value of ~1 μM. Proteasome inhibitor IX exhibits HCT116 p53+/+ cells growth inhibitory activity with an IC50 value of 1.49 μM. Proteasome inhibitor IX has potent anticancer activity .
    Proteasome inhibitor IX (Standard)
  • HY-181638
    4-Cl-Benzodioxolyl chalcone

    		Drug Derivative Metabolic Disease
    4-Cl-Benzodioxolyl chalcone is a type of chalcone. It reduces the viability of endometriotic cells while maintaining or increasing the viability of normal endometrial cells. 4-Cl-Benzodioxolyl chalcone can be used in the research of endometriosis .
    4-Cl-Benzodioxolyl chalcone

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