2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Ferroptosis Keap1-Nrf2 Glutathione Peroxidase Reactive Oxygen Species (ROS)
  4. Ferroptosis inducer-13

Ferroptosis inducer-13 is a 5′-prenylated chalcone derivative that effectively induces ferroptosis in human non-small cell lung cancer (NSCLC) cells by altering the activity of the Nrf2/xCT/GPX4 pathway. Ferroptosis inducer-13 exhibits potent anti-proliferative effects in vitro, and inhibits tumour growth in a NSCLC mouse model. Ferroptosis inducer-13 can be used for NSCLC research.

For research use only. We do not sell to patients.

Ferroptosis inducer-13

Ferroptosis inducer-13 Chemical Structure

CAS No. : 3085517-19-4

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Ferroptosis inducer-13 Related Antibodies

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Description

Ferroptosis inducer-13 is a 5′-prenylated chalcone derivative that effectively induces ferroptosis in human non-small cell lung cancer (NSCLC) cells by altering the activity of the Nrf2/xCT/GPX4 pathway. Ferroptosis inducer-13 exhibits potent anti-proliferative effects in vitro, and inhibits tumour growth in a NSCLC mouse model. Ferroptosis inducer-13 can be used for NSCLC research[1].

IC50 & Target[1]

GPX4

 

In Vitro

Ferroptosis inducer-13 (compound 4a) (72 h) exhibits potent broad-spectrum antiproliferative activity against cancer cells, with IC50 values of 2.11 μM (PC9), 2.17 μM (MDA-MB-231), 3.81 μM (SMMC-7721), and 4.10 μM (SGC-7901)[1].
Ferroptosis inducer-13 (0-40 μM; 24-72 h) exhibits significant anti-proliferative effects on NSCLC cells (PC9 and H1975) in a time- and concentration-dependent manner[1].
Ferroptosis inducer-13 (20 μM; 24 h) induces ferroptosis in NSCLC cells (PC9 and H1975)[1].
Ferroptosis inducer-13 (0-40 μM; 24 h) leads to GSH depletion and increases Fe2+, ROS and LPO levels, and induces ferroptosis through modulation of the Nrf2/xCT/GPX4 signaling pathway in PC9 and H1975 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ferroptosis inducer-13 Related Antibodies

Cell Viability Assay[1]

Cell Line: PC9, H1975
Concentration: 0, 2.5, 5, 10, 20, 40 μM
Incubation Time: 24, 48, 72 h
Result: Gradually decreased cell viability of PC9 and H1975 cells in a concentration manner.
Exhibited significant anti-proliferative effects on NSCLC cells (PC9 and H1975) in a time- and concentration-dependent manner.

Cell Viability Assay[1]

Cell Line: PC9, H1975
Concentration: 20 μM
Incubation Time: 12 h
Result: Significantly enhanced cell viability by approximately 20% when combined with ferroptosis inhibitor.

Immunofluorescence[1]

Cell Line: PC9, H1975
Concentration: 20 μM
Incubation Time: 24 h
Result: Moderately reversed the GPX expression when combined with ferroptosis inhibitor.

Western Blot Analysis[1]

Cell Line: PC9, H1975
Concentration: 0, 5, 10, 20, 40 μM
Incubation Time: 24 h
Result: Significantly decreased Nrf2 levels in both cytoplasmic and nuclear fractions while reducing xCT and GPX4 expression.
In Vivo

Ferroptosis inducer-13 (2 and 5 mg/kg; i.p.; every 3 days for 18 days) suppresses tumor growth in a PC9 xenograft mouse model with favorable safety profiles[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Balb/c nude mice (16-20 g) subcutaneously injected with PC9 cells[1]
Dosage: 2, 5 mg/kg
Administration: i.p.; every 3 days for 18 days
Result: Exhibited tumor growth suppression with minimal impact on body weight.
Caused no significant organ toxicity in mice.
Significantly downregulated the protein expression of xCT and GPX4 in tumor tissues compared with the control group.
Molecular Weight

337.41

Formula

C21H23NO3
CAS No.
SMILES

COC1=CC(OC)=C(C=C1C(/C=C/C2=NC=CC=C2)=O)C/C=C(C)\C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ferroptosis inducer-13 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ferroptosis inducer-133085517-19-4Ferroptosis inducer13Ferroptosis inducer 13FerroptosisKeap1-Nrf2Glutathione PeroxidaseReactive Oxygen Species (ROS)ferroptosisanticancer agentsNrf2/xCT/GPX4 axisInhibitorinhibitorinhibit

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