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Cat. No.: HY-137831

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TLBC

TLBC, a boronic-chalcone derivative, shows a dose-dependent inhibition with IC₅₀ values of 5.5-25.5 μM in various glioma cell lines. TLBC induces apoptosis independent of changes to the tumor suppressor p53.

For research use only. We do not sell to patients.

CAS No.: 562823-84-1
Formula: C₁₅H₁₂BIO₃
Molecular Weight:377.97

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

TLBC Chemical Structure

CAS No.: 562823-84-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
MCF-10A	IC₅₀	75 μM Compound: 3a	Inhibitory activity against MCF-10A human breast cell line Inhibitory activity against MCF-10A human breast cell line	[PMID: 12825923]
MCF-12A	IC₅₀	63 μM Compound: 3a	Inhibitory activity against MCF-12A human breast cell line Inhibitory activity against MCF-12A human breast cell line	[PMID: 12825923]
MCF7	IC₅₀	7 μM Compound: 3a	Inhibitory activity against Wt-MCF7 human breast cell line Inhibitory activity against Wt-MCF7 human breast cell line	[PMID: 12825923]
MDA-MB-231	IC₅₀	8.8 μM Compound: 3a	Inhibitory activity against MDA-MB-231 human breast cell line Inhibitory activity against MDA-MB-231 human breast cell line	[PMID: 12825923]
MDA-MB-435	IC₅₀	10 μM Compound: 3a	Inhibitory activity against MDA-MB-435 human breast cell line Inhibitory activity against MDA-MB-435 human breast cell line	[PMID: 12825923]

Chemical Information

CAS No. 562823-84-1
Molecular Weight 377.97
Formula C₁₅H₁₂BIO₃
SMILES

OB(C1=CC=C(C(/C=C/C2=CC=C(I)C=C2)=O)C=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Takashi Sasayama, et al. Trans-4-lodo,4'-boranyl-chalcone induces antitumor activity against malignant glioma cell lines in vitro and in vivo. J Neurooncol. 2007 Nov;85(2):123-32. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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