Design, synthesis, and evaluation of novel boronic-chalcone derivatives as antitumor agents
- J Med Chem. 2003 Jul 3;46(14):2813-5. doi: 10.1021/jm030213+.
Affiliations
- 1. Division of Experimental Therapeutics, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA.
PMID: 12825923
DOI: 10.1021/jm030213+
Abstract
A series of boronic-chalcone derivatives were synthesized and tested for antitumor activity against human Breast Cancer cell lines. The results show the boronic-chalcones are more toxic to Breast Cancer cells compared to normal breast cells than other known Chalcones.