4-DMA-3'-OH-Chalcone
4-DMA-3'-OH-Chalcone (compound 24) is a synthetic chalcone derivative and selective cytotoxic agent.4-DMA-3'-OH-Chalcone reduces viability of endometriotic cells, while preserving or enhancing viability of eutopic endometrial cells.4-DMA-3'-OH-Chalcone can be used for the research of endometriosis.
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- CAS No.: 946437-21-4
- Formule: C17H17NO2
- Masse moléculaire:267.32
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L929 | CC50 |
200 μM
Compound: 2
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Cytotoxicity in mouse NCTC-929 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity in mouse NCTC-929 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 31000155] |
In Vitro
4-DMA-3'-OH-Chalcone (compound 24) (200 μM; 24 h) selectively reduces 12Z endometriotic cell viability to 48.65% while increasing Ishikawa eutopic endometrial cell viability to 109.23%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Ishikawa (eutopic endometrial) epithelial cell line, 12Z (endometriotic) epithelial cell line
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Concentration:200 μM
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Incubation Time:24 h
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Result:Increased Ishikawa cell viability to 109.23% relative to untreated control cells.
Reduced 12Z cell viability to 48.65% relative to untreated control cells.
Induced a statistically significant 60.58 percentage point difference in viability between the two cell lines.
Chemical Information
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CAS No. 946437-21-4
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Masse moléculaire 267.32
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Formule C17H17NO2
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SMILES
O=C(C1=CC=CC(O)=C1)/C=C/C2=CC=C(N(C)C)C=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
4-DMA-3'-OH-Chalcone Related Classifications
HY-181637 Related Classifications
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