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Results for "

helper lipid

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Angiotensin-converting Enzyme (ACE) (1) Bacterial (2) Biochemical Assay Reagents (6) Ceramidase (1) Cholinesterase (ChE) (1) Endogenous Metabolite (13) Environmental Pollutants (2) Ferroptosis (2) Fluorescent Dye (1) Fungal (1) Isotope-Labeled Compounds (3) Keap1-Nrf2 (2) Liposome (15) Reactive Oxygen Species (ROS) (10) Reference Standards (3) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (5) Infection (1) Inflammation/Immunology (9) Metabolic Disease (5) Neurological Disease (3)
Click Chemistry:	DBCO (1)
Oligonucleotides:	Fluorescent Lipids (1) Pegylated Lipids (6) Liposomal Film-forming Agents (1) Emulsifiers (1) Solubilizing Agents (1) Phospholipids (1) Cationic Lipids (4)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

MCE Kits

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112754A

DOTAP chloride 10+ Cited Publications 1,2-Dioleoyl-3-trimethylammonium-propane chloride	Liposome	Cancer
DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid .

HY-112005

DOPE 5+ Cited Publications Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine	Liposome Endogenous Metabolite	Inflammation/Immunology
DOPE (Dioleoylphosphatidylethanolamine) is a neutral **helper lipid** for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA .

HY-B2130

Uric acid Maximum Cited Publications 21 Publications Verification	Environmental Pollutants Endogenous Metabolite Reactive Oxygen Species (ROS)	Cardiovascular Disease Inflammation/Immunology
Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation .

HY-B2130A

Uric acid sodium Maximum Cited Publications 21 Publications Verification Monosodium urate	Reactive Oxygen Species (ROS) Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
Uric acid sodium (Monosodium urate), scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid sodium can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation .

HY-145405

C12-200 Maximum Cited Publications 16 Publications Verification	Liposome	Others
C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B .

HY-D1168

Oil Red O 10+ Cited Publications	Environmental Pollutants Fluorescent Dye	Metabolic Disease
Oil Red O is a fat-soluble diazol dye, with a maximum absorption at 518 nm. Oil Red O stains neutral lipids and cholesteryl esters but not biological membranes. Oil Red O can be used for detecting and quantifying hepatic steatosis in mouse liver biopsies. Oil Red O staining efficiently helps to visualize the radical changes that occur in tissues as metabolic disease occurs and progresses .

HY-B2130S1

Uric acid-15N2	Endogenous Metabolite Reactive Oxygen Species (ROS)	Inflammation/Immunology
Uric acid- ¹⁵N₂ is the ¹⁵N labeled Uric acid . Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation .

HY-N6929

Angelic acid 1 Publications Verification	Ferroptosis Keap1-Nrf2 Reactive Oxygen Species (ROS)	Neurological Disease Cancer
Angelic acid is a ferroptosis inducer, targeting NRF2 degradation. Angelic acid binds to NRF2 protein and promotes NRF2 degradation via ubiquitination-proteasome pathway, relieves the inhibitory effect of NRF2 on oxidative stress and lipid peroxidation. Then, Angelic acid induces ferroptosis in tumor cells. Angelic acid can enhance the accumulation of intracellular reactive oxygen species (ROS), upregulate ferroptosis-related markers CHAC1 and PTGS2, and synergize with ferroptosis inducers to enhance anti-tumor effects. Angelic acid also has the activity of scavenging UVA-induced ROS in vitro, inhibiting skin fibroblast senescence and extracellular matrix degradation. Angelic Acid helps wound healing with sedative activity .

HY-144012

DPPE-PEG2000 ammonium 16:0 PEG2000 PE ammonium; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] ammonium	Liposome	Others
DPPE-PEG2000 ammonium (16:0 PEG5000 PE) is a *polymer-lipid* conjugate and LipoParticle** stabilizer with a PEG chain of 5,000 g/mol molecular weight attached to its polar head, and it can be internalized by biological membranes. DPPE-PEG2000 ammonium enables LipoParticle to maintain colloidal stability after 20-fold dilution in PBS or cell culture medium, and prevents aggregate formation during lyophilization and rehydration. DPPE-PEG2000 ammonium helps enhance the non-cytotoxic property of LipoParticle formulations against human osteoblasts. DPPE-PEG2000 ammonium serves as a PEG lipid functional end group for synthesizing liposomes (LPs), is used in the design of conjugated polymer nanoparticles, and applies to research related to bone and joint infections .

HY-N5139

Lecithins, egg 1 Publications Verification Lecithins, egg yolk; Belovo PL 85	Cholinesterase (ChE) Angiotensin-converting Enzyme (ACE) Bacterial	Infection Neurological Disease Metabolic Disease Inflammation/Immunology
Lecithins, egg (Lecithins, egg yolk; Belovo PL 85) is an orally active natural phospholipid mixture extracted from egg yolks . Lecithins, egg inhibits the activities of acetylcholinesterase (AChE) and angiotensin-converting enzyme (ACE). Lecithins, egg exhibits antibacterial, antioxidant and anti-inflammatory activities, and helps delay cellular senescence. Lecithins, egg enhances nerve conduction, improves memory and cognitive function, and exerts positive effects on delaying neurodegenerative diseases. Lecithins, egg promotes lipid absorption and alleviates diarrhea. Lecithins, egg acts as a high-efficiency drug carrier for the preparation of targeted drug delivery systems such as liposomes .

HY-112754AGL

DOTAP chloride (GMP Like) 1,2-Dioleoyl-3-trimethylammonium-propane chloride (GMP Like)	Liposome	Others
DOTAP chloride (GMP Like) is the GMP Like class DOTAP chloride (HY-112754A). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOTAP chloride is a cationic lipid with good membrane fusion ability and biocompatibility. DOTAP chloride (GMP Like) can be used as an excipient for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) without the use of helper lipid .

HY-B2130S

Uric acid-13C,15N3	Reactive Oxygen Species (ROS) Endogenous Metabolite	Inflammation/Immunology
Uric acid- ¹³C, ¹⁵N₃ is the ¹³C-labeled and ¹⁵N-labeled Uric acid. Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation .

HY-W587552

1,3-Diolein	Liposome Endogenous Metabolite
1,3-Diolein is a phospholipid compound that has the activity of regulating cell membrane fluidity and signal transduction. 1,3-Diolein is widely used in cell biology research to study lipid-mediated signal transduction pathways and membrane protein interactions. 1,3-Diolein can also serve as a functional carrier in compound delivery systems to help improve the bioavailability of compounds.

HY-144012H

DPPE-PEG5000 16:0 PEG5000 PE; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000] ammonium	Liposome	Others
DPPE-PEG5000 (16:0 PEG5000 PE) is a *polymer-lipid* conjugate and LipoParticle** stabilizer with a PEG chain of 5,000 g/mol molecular weight attached to its polar head, and it can be internalized by biological membranes. DPPE-PEG5000 enables LipoParticle to maintain colloidal stability after 20-fold dilution in PBS or cell culture medium, and prevents aggregate formation during lyophilization and rehydration. DPPE-PEG5000 helps enhance the non-cytotoxic property of LipoParticle formulations against human osteoblasts. DPPE-PEG5000 serves as a PEG lipid functional end group for synthesizing liposomes (LPs), is used in the design of conjugated polymer nanoparticles, and applies to research related to bone and joint infections .

HY-W440690

Cholesterol-PEG2000-amine	Liposome	Cancer
Cholesterol-PEG2000-amine is a pegylated lipids which can be used for preparation of liposome or nanoparticle. The lipophilic moiety can encapsulate hydrophobic drugs whereas the hydrophilic PEG chain helps the overal water solubility of the micelles.

HY-126912A

Lauroyl coenzyme A lithium	Biochemical Assay Reagents Endogenous Metabolite	Others
Lauroyl coenzyme A lithium salt is an intermediary in fatty acid synthesis or metabolism, formed by combining long-chain fatty acids (or lauric acid) with coenzyme A. Lauroyl coenzyme A lithium salt is involved in lipid biosynthesis and fatty acid transport, in which coenzyme A acts as a transport molecule to help move and target specific compounds.

HY-N12762

DGTS	Liposome	Others
DGTS, as described, is a structural isomer of DGTA and one of the most common betaine lipids found in microalgae, particularly abundant in Chlorophyceae . DGTS is a helper lipid that is structurally similar to DSPE or DOPE.

HY-164035

DOPE-PEG2000-DBCO	Biochemical Assay Reagents	Others
DOPE-PEG2000-DBCO is a PEG lipid with a DOPE and a DBCO as functional groups. DOPE can be used as a helper lipid in gene transfection. PEG is used in drug delivery system. DBCO can be used for click chemistry .

HY-W440706

Cholesterol-PEG2000-alcohol	Liposome	Cancer
Cholesterol-PEG2000-alcohol is a pegylated lipids which can be used for preparation of liposome or nanoparticle. The lipophilic moiety can encapsulate hydrophobic drugs whereas the hydrophilic PEG chain helps the overal water solubility of the micelles. The amine can react with an activated NHS ester to form a stable amide bond.

HY-B2130R

Uric acid (Standard)	Reference Standards Reactive Oxygen Species (ROS) Endogenous Metabolite	Inflammation/Immunology
Uric acid (Standard) is the analytical standard of Uric acid. This product is intended for research and analytical applications. Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation .

HY-N15841

C25 Ceramide (d18:1/25:0)	Ceramidase	Others
C25 Ceramide (d18:1/25:0) is an endogenous ultra-long-chain ceramide that antagonizes the detrimental effects of long-chain ceramides on insulin sensitivity. C25 Ceramide (d18:1/25:0) is specifically enriched in oxidative skeletal muscle fibers, where it serves dual roles in providing structural support to cell membranes and regulating cellular signaling. By participating in the regulation of lipid homeostasis within muscle fibers, C25 Ceramide (d18:1/25:0) helps maintain normal insulin signaling. C25 Ceramide (d18:1/25:0) is primarily utilized in research concerning metabolic diseases—particularly in mechanistic studies investigating the muscle fiber type-specific aspects of insulin resistance .

HY-P10514

Transportan 10	Small Interfering RNA (siRNA)	Others
Transportan 10 is a derivative of Transportan (HY-P1732) and is an amphiphilic cell penetrating peptide (CPP). Transportan 10 helps molecules penetrate cell membrane barriers by directly interacting with the lipid bilayer. Transportan 10 can be used in gene therapy or siRNA delivery vector research .

HY-112005GL

DOPE (GMP Like) Dioleoylphosphatidylethanolamine (GMP Like); 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (GMP Like)	Liposome Endogenous Metabolite	Inflammation/Immunology
DOPE (GMP Like) is the GMP Like class DOPE (HY-112005), and can be used as pharmaceutical excipients. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOPE is a neutral **helper lipid** for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA .

HY-124187

Pinolenic acid ethyl ester Ethyl pinolenate	Biochemical Assay Reagents	Others
Pinolenic acid is a polyunsaturated fatty acid found in the seed oils of red pine (Pinus orientalis) and maritime pine (Pinus pinaster). Both oils were found to have lipid-lowering properties. A diet containing marine pine nut oil (MPSO) reduces HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to reduce cholesterol efflux in vitro. Korean pine nut oil supplements may help obesity by reducing appetite. People who take this oil experience an increase in the satiety hormones CCK and GLP-1 and a decrease in appetite. The activity of the oil is attributed to pinolenic acid. Pinolenic acid is not metabolized to arachidonic acid and can reduce the level of arachidonic acid in the phosphatidylinositol fraction of HepG2 cells from 15.9% to 7.0%. Pinolenic acid ethyl ester is a neutral, more lipophilic form of the free acid.

HY-N6929R

Angelic acid (Standard)	Reference Standards Ferroptosis Keap1-Nrf2 Reactive Oxygen Species (ROS)	Neurological Disease Cancer
Angelic acid (Standard)) is the analytical standard of Angelic acid (HY-N6929). This product is intended for research and analytical applications. Angelic acid is a ferroptosis inducer, targeting NRF2 degradation. Angelic acid binds to NRF2 protein and promotes NRF2 degradation via ubiquitination-proteasome pathway, relieves the inhibitory effect of NRF2 on oxidative stress and lipid peroxidation. Then, Angelic acid induces ferroptosis in tumor cells. Angelic acid can enhance the accumulation of intracellular reactive oxygen species (ROS), upregulate ferroptosis-related markers CHAC1 and PTGS2, and synergize with ferroptosis inducers to enhance anti-tumor effects. Angelic acid also has the activity of scavenging UVA-induced ROS in vitro, inhibiting skin fibroblast senescence and extracellular matrix degradation. Angelic Acid helps wound healing with sedative activity .

HY-168776

(S)-C12-200	Biochemical Assay Reagents	Others
(S)-C12-200 is the (S)-isomer of C12-200 (HY-145405), an ionizable cationic lipid and helper lipid. (S)-C12-200 can be utilized in the formation of lipid nanoparticles and mRNA delivery .

HY-160275

DOPE-PEG2000-Fluor 555	Liposome	Others
DOPE-PEG2000-Fluor 555 is a PEG-lipid-dye conjugate featuring a DOPE phospholipid and a Fluor 555 dye. DOPE (HY-112005) is a neutral helper lipid for cationic liposome. Fluor 555 is a fluorescent dye .

HY-E70256

12:0 Coenzyme A triammonium Lauroyl coenzyme A triammonium; S-Dodecanoate-CoA triammonium; S-Dodecanoate-CoA triammonium	Biochemical Assay Reagents Endogenous Metabolite	Others
12:0 Coenzyme A (Lauroyl coenzyme A triammonium) is an intermediary in fatty acid synthesis or metabolism, formed by combining long-chain fatty acids (or lauric acid) with coenzyme A. 12:0 Coenzyme A is involved in lipid biosynthesis and fatty acid transport, in which coenzyme A acts as a transport molecule to help move and target specific compounds .

HY-B2130AR

Uric acid sodium (Standard) Monosodium urate (Standard)	Reactive Oxygen Species (ROS) Endogenous Metabolite Reference Standards	Cardiovascular Disease Metabolic Disease
Uric acid (sodium) (Standard) is the analytical standard of Uric acid (sodium). This product is intended for research and analytical applications. Uric acid sodium (Monosodium urate), scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid sodium can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation .

HY-W780166

Uric acid-13C	Reactive Oxygen Species (ROS)	Cardiovascular Disease
Uric acid- ¹³C is the ¹³C-labeled Uric acid (HY-B2130). Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation .

HY-N13221

Apple Cider Vinegar Powder	Bacterial Reactive Oxygen Species (ROS) Fungal	Cardiovascular Disease Metabolic Disease Cancer
Apple Cider Vinegar Powder is a soluble powdered form of apple cider vinegar. Apple Cider Vinegar Powder has anti-bacterial, anti-oxidant, and antibiotic properties and can help maintain the acid-base balance in the blood. Apple Cider Vinegar Powder can lower blood sugar and lipid levels. Apple Cider Vinegar Powder is used in research related to tumors, diabetes, and cardiovascular diseases .

HY-W1130458

503O8,12	Liposome	Inflammation/Immunology
503O8,12 is an ionizable cationic lipidoid that enables mRNA delivery to the spleen and lungs in mice when formulated into lipid nanoparticles with neutral helper lipid DOPE[1].

HY-112754AS

DOTAP-d9 chloride	Isotope-Labeled Compounds Liposome	Cancer
DOTAP-d₉ chloride is the deuterium labeled DOTAP chloride (HY-112754A). DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid .

HY-112005S

DOPE-d62 Dioleoylphosphatidylethanolamine-d₆₂; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-d₆₂	Isotope-Labeled Compounds	Inflammation/Immunology
DOPE-d₆₂ (Dioleoylphosphatidylethanolamine-d₆₂) is the deuterium labeled DOPE (HY-112005). DOPE (Dioleoylphosphatidylethanolamine) is a neutral **helper lipid** for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA .

HY-W1130459

(R)-C12-200	Liposome	Cancer
(R)-C12-200 is the (R)-isomer of C12-200 (HY-145405), an ionizable cationic lipid and helper lipid. (R)-C12-200 enables functional mRNA delivery to head and neck squamous cell carcinoma xenograft tumor cells in NU/J immunocompromised mice, with minimal off-target delivery to liver or spleen. (R)-C12-200 can be utilized in the formation of lipid nanoparticles and mRNA delivery .

HY-167810

1,3-Dipentadecanoin(C15:0)	Endogenous Metabolite Biochemical Assay Reagents
1,3-Dipentadecanoin(C15:0) is a long-chain triglyceride with substrate activity for lipid metabolism studies. 1,3-Dipentadecanoin(C15:0) is used as a model compound for studying the hydrolysis of triglycerides by lipase. 1,3-Dipentadecanoin(C15:0) can help understand the metabolic mechanism of triglycerides in chemical research.

HY-151994S

1,3-Diolein-d66	Isotope-Labeled Compounds Endogenous Metabolite	Others
1,3-Diolein-d₆₆ is deuterium labeled 1,3-Diolein. 1,3-Diolein is a phospholipid compound that has the activity of regulating cell membrane fluidity and signal transduction. 1,3-Diolein is widely used in cell biology research to study lipid-mediated signal transduction pathways and membrane protein interactions. 1,3-Diolein can also serve as a functional carrier in compound delivery systems to help improve the bioavailability of compounds .

Bile Acids Library	61 compounds
Bile acids are a class of amphiphilic molecules derived from the metabolic breakdown of cholesterol, primarily synthesized in the liver, and play a crucial role in the intestines. Based on their structural characteristics, bile acids are mainly divided into two categories: free bile acids (including Cholic acid, Deoxycholic acid, Chenodeoxycholic acid) and conjugated bile acids (including Glycocholic acid, Glycochenodeoxycholic acid, Taurocholic acid, etc.). Bile acids play a significant role in the pathophysiological research of liver and gastrointestinal diseases and are closely associated with the occurrence of metabolic diseases such as obesity, type II diabetes, non-alcoholic fatty liver disease, and atherosclerosis. Bile acids maintain metabolic balance within the body by regulating sugar metabolism, lipid metabolism, and amino acid metabolism, and they influence the activity of metabolism-related enzymes and transporters. In addition, Bile acids can also be used to construct a bile acid metabolism research platform, which helps to delve into the metabolic pathways and dynamic changes of bile acids in living organisms and aids in identifying new biomarkers for certain diseases. MCE included 61 bile acids, including Cholic acid, Deoxycholic acid, Glycocholic acid, etc., which are effective tools for the study of liver and gallbladder diseases.

Glutamine Metabolism Compound Library	1,690 compounds
Glutamine is an important metabolic fuel that helps rapidly proliferating cells meet the increased demand for ATP, biosynthetic precursors, and reducing agents. Glutamine Metabolism pathway involves the initial deamination of glutamine by glutaminase(GLS), yielding glutamate and ammonia. Glutamate is converted to the TCA cycle intermediate α-ketoglutarate (α-KG) by either glutamate dehydrogenase (GDH) or by the alanine or aspartate transaminases (TAs), to produce both ATP and anabolic carbons for the synthesis of amino acids, nucleotides and lipids. During periods of hypoxia or mitochondrial dysfunction, α-KG can be converted to citrate in a reductive carboxylation reaction catalyzed by IDH2. The newly formed citrate exits the mitochondria where it is used to synthesize fatty acids and amino acids and produce the reducing agent, NADPH. Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in glutamine metabolic processes could provide novel approaches to improve cancer treatment. MCE owns a unique collection of 1,690 compounds targeting the mainly proteins and enzymes involved in glutamine metabolism pathway. Glutamine Metabolism compound library is a useful tool for intervention in glutamine metabolic processes.

Oil Red O 10+ Cited Publications	Fluorescent Dyes
Oil Red O is a fat-soluble diazol dye, with a maximum absorption at 518 nm. Oil Red O stains neutral lipids and cholesteryl esters but not biological membranes. Oil Red O can be used for detecting and quantifying hepatic steatosis in mouse liver biopsies. Oil Red O staining efficiently helps to visualize the radical changes that occur in tissues as metabolic disease occurs and progresses .

DOTAP chloride (GMP Like) 1,2-Dioleoyl-3-trimethylammonium-propane chloride (GMP Like)	Fluorescent Dyes
DOTAP chloride (GMP Like) is the GMP Like class DOTAP chloride (HY-112754A). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOTAP chloride is a cationic lipid with good membrane fusion ability and biocompatibility. DOTAP chloride (GMP Like) can be used as an excipient for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) without the use of helper lipid .

DOPE (GMP Like) Dioleoylphosphatidylethanolamine (GMP Like); 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (GMP Like)	Fluorescent Dyes
DOPE (GMP Like) is the GMP Like class DOPE (HY-112005), and can be used as pharmaceutical excipients. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOPE is a neutral **helper lipid** for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA .

DOTAP chloride 10+ Cited Publications 1,2-Dioleoyl-3-trimethylammonium-propane chloride	Biochemical Assay Reagents
DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B2130

Uric acid Maximum Cited Publications 21 Publications Verification	Structural Classification Classification of Application Fields Endocrine diseases Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Inflammation/Immunology Disease Research Fields Cancer Source Classification	Environmental Pollutants Endogenous Metabolite Reactive Oxygen Species (ROS)
Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation .

HY-B2130A

Uric acid sodium Maximum Cited Publications 21 Publications Verification Monosodium urate	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Reactive Oxygen Species (ROS) Endogenous Metabolite
Uric acid sodium (Monosodium urate), scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid sodium can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation .

HY-N6929

Angelic acid 1 Publications Verification	Structural Classification Ketones, Aldehydes, Acids Umbelliferae Plants Echinacea angustifolia DC. Source Classification	Ferroptosis Keap1-Nrf2 Reactive Oxygen Species (ROS)
Angelic acid is a ferroptosis inducer, targeting NRF2 degradation. Angelic acid binds to NRF2 protein and promotes NRF2 degradation via ubiquitination-proteasome pathway, relieves the inhibitory effect of NRF2 on oxidative stress and lipid peroxidation. Then, Angelic acid induces ferroptosis in tumor cells. Angelic acid can enhance the accumulation of intracellular reactive oxygen species (ROS), upregulate ferroptosis-related markers CHAC1 and PTGS2, and synergize with ferroptosis inducers to enhance anti-tumor effects. Angelic acid also has the activity of scavenging UVA-induced ROS in vitro, inhibiting skin fibroblast senescence and extracellular matrix degradation. Angelic Acid helps wound healing with sedative activity .

HY-N12762

DGTS	Structural Classification Microorganisms Lipid Source Classification	Liposome
DGTS, as described, is a structural isomer of DGTA and one of the most common betaine lipids found in microalgae, particularly abundant in Chlorophyceae . DGTS is a helper lipid that is structurally similar to DSPE or DOPE.

HY-B2130R

Uric acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Cancer Source Classification	Reference Standards Reactive Oxygen Species (ROS) Endogenous Metabolite
Uric acid (Standard) is the analytical standard of Uric acid. This product is intended for research and analytical applications. Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation .

HY-N15841

C25 Ceramide (d18:1/25:0)	Structural Classification Lipid	Ceramidase
C25 Ceramide (d18:1/25:0) is an endogenous ultra-long-chain ceramide that antagonizes the detrimental effects of long-chain ceramides on insulin sensitivity. C25 Ceramide (d18:1/25:0) is specifically enriched in oxidative skeletal muscle fibers, where it serves dual roles in providing structural support to cell membranes and regulating cellular signaling. By participating in the regulation of lipid homeostasis within muscle fibers, C25 Ceramide (d18:1/25:0) helps maintain normal insulin signaling. C25 Ceramide (d18:1/25:0) is primarily utilized in research concerning metabolic diseases—particularly in mechanistic studies investigating the muscle fiber type-specific aspects of insulin resistance .

HY-N6929R

Angelic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Umbelliferae Plants Echinacea angustifolia DC. Source Classification	Reference Standards Ferroptosis Keap1-Nrf2 Reactive Oxygen Species (ROS)
Angelic acid (Standard)) is the analytical standard of Angelic acid (HY-N6929). This product is intended for research and analytical applications. Angelic acid is a ferroptosis inducer, targeting NRF2 degradation. Angelic acid binds to NRF2 protein and promotes NRF2 degradation via ubiquitination-proteasome pathway, relieves the inhibitory effect of NRF2 on oxidative stress and lipid peroxidation. Then, Angelic acid induces ferroptosis in tumor cells. Angelic acid can enhance the accumulation of intracellular reactive oxygen species (ROS), upregulate ferroptosis-related markers CHAC1 and PTGS2, and synergize with ferroptosis inducers to enhance anti-tumor effects. Angelic acid also has the activity of scavenging UVA-induced ROS in vitro, inhibiting skin fibroblast senescence and extracellular matrix degradation. Angelic Acid helps wound healing with sedative activity .

HY-B2130AR

Uric acid sodium (Standard) Monosodium urate (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reactive Oxygen Species (ROS) Endogenous Metabolite Reference Standards
Uric acid (sodium) (Standard) is the analytical standard of Uric acid (sodium). This product is intended for research and analytical applications. Uric acid sodium (Monosodium urate), scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid sodium can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation .

Cat. No.	Product Name	Chemical Structure

HY-B2130S1

Uric acid-15N2
Uric acid- ¹⁵N₂ is the ¹⁵N labeled Uric acid . Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation .

HY-B2130S

Uric acid-13C,15N3
Uric acid- ¹³C, ¹⁵N₃ is the ¹³C-labeled and ¹⁵N-labeled Uric acid. Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation .

HY-W780166

Uric acid-13C
Uric acid- ¹³C is the ¹³C-labeled Uric acid (HY-B2130). Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation .

HY-112754AS

DOTAP-d9 chloride
DOTAP-d₉ chloride is the deuterium labeled DOTAP chloride (HY-112754A). DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid .

HY-112005S

DOPE-d62
DOPE-d₆₂ (Dioleoylphosphatidylethanolamine-d₆₂) is the deuterium labeled DOPE (HY-112005). DOPE (Dioleoylphosphatidylethanolamine) is a neutral **helper lipid** for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA .

HY-151994S

1,3-Diolein-d66

1,3-Diolein-d₆₆ is deuterium labeled 1,3-Diolein. 1,3-Diolein is a phospholipid compound that has the activity of regulating cell membrane fluidity and signal transduction. 1,3-Diolein is widely used in cell biology research to study lipid-mediated signal transduction pathways and membrane protein interactions. 1,3-Diolein can also serve as a functional carrier in compound delivery systems to help improve the bioavailability of compounds .

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112754AGL

DOTAP chloride (GMP Like) 1,2-Dioleoyl-3-trimethylammonium-propane chloride (GMP Like)	Liposome	Others
DOTAP chloride (GMP Like) is the GMP Like class DOTAP chloride (HY-112754A). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOTAP chloride is a cationic lipid with good membrane fusion ability and biocompatibility. DOTAP chloride (GMP Like) can be used as an excipient for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) without the use of helper lipid .

HY-112005GL

DOPE (GMP Like) Dioleoylphosphatidylethanolamine (GMP Like); 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (GMP Like)	Liposome Endogenous Metabolite	Inflammation/Immunology
DOPE (GMP Like) is the GMP Like class DOPE (HY-112005), and can be used as pharmaceutical excipients. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOPE is a neutral **helper lipid** for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA .

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helper lipid

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Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

MCE Kits

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

GMP Molecules

Natural
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