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Results for "

mRNA+delivery

" in MedChemExpress (MCE) Product Catalog:

45

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14

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1

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35

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-145405
    C12-200
    Maximum Cited Publications
    16 Publications Verification

    		 Liposome Others
    C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B .
    C12-200
  • HY-138171
    Lipid 5
    3 Publications Verification

    		 Liposome Others
    Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects .
    Lipid 5
  • HY-148842
    C14-4

    		Liposome Others
    C14-4 is an ionizable lipid utilized for the synthesis of lipid nanoparticles (LNPs). C14-4 enhances mRNA delivery, enabling the effective transport of mRNA to primary human T cells, which in turn induces functional protein expression. C14-4 demonstrates high transfection efficiency while maintaining low cytotoxicity .
    C14-4
  • HY-151507
    306Oi10
    1 Publications Verification

    		 Liposome Others
    306Oi10 is a branched ionizable lipid that can be used to construct lipid nanoparticles (LNPs) for delivering messenger RNA. The surface ionization of lipid nanoparticles is related to the effectiveness of mRNA delivery. The tail of 306Oi10 has a one-carbon branch, which provides it with stronger surface ionization compared to lipids with linear tails, thereby enhancing its mRNA delivery efficacy. 306Oi10 can be used in research related to mRNA delivery .
    306Oi10
  • HY-167036
    DMG-PEG2000-Mal

    		Biochemical Assay Reagents Others
    DMG-PEG2000-Mal is a pegylated lipid with a molecular weight of 2000. DMG-PEG-Mal serves as a component of lipid nanoparticles for mRNA delivery .
    DMG-PEG2000-Mal
  • HY-171306
    MK16

    		Liposome Others
    MK16 is a lipid material that can be used to construct blood-brain barrier penetrable lipid nanoparticles for mRNA delivery. MK16 facilitates blood-brain barrier crossing via γ-secretase-mediated and caveolae-mediated transcytosis. MK16 can be used for drug delivery research .
    MK16
  • HY-142977
    6-Oxohexyl 2-hexyldecanoate, 80% (ELSD)

    		Drug Intermediate Others
    6-Oxohexyl 2-hexyldecanoate, 80% (ELSD) is an intermediate in the synthesis of ALC-0315. 6-Oxohexyl 2-hexyldecanoate, 80% (ELSD) can be used in research on drug delivery, such as mRNA delivery .
    6-Oxohexyl 2-hexyldecanoate, 80% (ELSD)
  • HY-145795
    OF-02

    		Liposome Others
    OF-02 is an ionizable lipid for mRNA delivery and a key component of lipid nanoparticles (LNPs). OF-02 is protonated in the acidic endosomal environment to promote endosomal escape of mRNA and efficiently induce protein expression in target cells. OF-02 relies on the pH-responsive membrane fusion properties to form a complex with mRNA and destroy the endosomal membrane structure to achieve mRNA release in the cytoplasm. OF-02 is mainly used in the development of mRNA vaccines, gene editing, and protein replacement therapy[1][2][3].
    OF-02
  • HY-N16040
    DMG-pSar25

    		Liposome Others
    DMG-pSar25 is a double lipid-tailed polysarcosine lipid with 25 sarcosine moieties, serving as a PEG lipid substitute in lipid nanoparticle formulations for mRNA delivery. DMG-pSar25 supports mRNA delivery in lipid nanoparticle formulations .
    DMG-pSar25
  • HY-148049
    TT3

    		Liposome Others
    TT3 is an ionizable lipid-like material and a lipid nanoparticle (LLNs)-based mRNA delivery vector. TT3 exhibits liver and spleen specificity and excellent delivery efficiency .
    TT3
  • HY-159726
    C10-200

    		Liposome Others
    C10-200 is an ionizable cationic lipid that can be used to generate lipid nanoparticles (LNPs). C10-200 is used in the study of mRNA delivery .
    C10-200
  • HY-151509
    A2-Iso5-2DC18

    		Liposome Cancer
    A2-Iso5-2DC18 is a dihydroimidazole-linked lipid, served as potent mRNA delivery vehicle. A2-Iso5-2DC18 can be used for antitumor research, including B16F10 melanoma. .
    A2-Iso5-2DC18
  • HY-153879
    C12-TLRa

    		Liposome Toll-like Receptor (TLR) Infection Inflammation/Immunology
    C12-TLRa is an ionized adjuvant lipid. C12-TLRa targets TLR7/8 receptors in endosomes. C12-TLRa enhances mRNA delivery as a structural component of LNPs. C12-TLRa enhances innate immune responses. C12-TLRa can be used for the research of SARS-CoV-2 mRNA vaccine .
    C12-TLRa
  • HY-170704
    DSPE-PEG2000-TCO

    		Liposome Metabolic Disease Cancer
    DSPE-PEG2000-TCO is a click chemistry coupling partner. DSPE-PEG2000-TCO undergoes a reverse electron-demand Diels-Alder click reaction to form a covalent linkage with tetrazine-modified Cetuximab (HY-P9905). DSPE-PEG2000-TCO maintains the stability of lipid nanoparticles (LNPs) and has high mRNA encapsulation efficiency, which supports cellular uptake and mRNA transfection. DSPE-PEG2000-TCO is used to prepare EGFR-targeted and APN-targeted mRNA-loaded LNPs, mediating receptor-dependent endocytosis, mRNA delivery, and intestinal epithelial transcytosis .
    DSPE-PEG2000-TCO
  • HY-W590683
    9A1P9

    		Liposome Others
    9A1P9 is a multi-tail ionizable cationic phospholipid. 9A1P9 induces membrane destabilization. 9A1P9 can be used for mRNA delivery t .
    9A1P9
  • HY-153372
    93-O17S

    		Liposome Others
    93-O17S is an ionizable lipid. 93-O17S is involved in the construction of LNP. 93-O17S can achieve mRNA delivery to the spleen .
    93-O17S
  • HY-164190
    m7(3'Ma-Biotin)Gppp(2'OMe)ApG ammonium solution (25mM)

    		DNA/RNA Synthesis Others
    m7(3'Ma-Biotin)Gppp(2'OMe)ApG ammonium is a Biotin-labled cap analogue that can be used for mRNA synthesis. The efficiency of mRNA delivery can be determined by the detection of Biotin by flow cytometry, which can be used to track mRNA in cells and in living animals and to screen delivery lipid ratios.
    m7(3'Ma-Biotin)Gppp(2'OMe)ApG ammonium solution (25mM)
  • HY-151511
    A12-Iso5-2DC18

    		Liposome Cancer
    A12-Iso5-2DC18, an ionizable cationic lipid, is a potent mRNA delivery lipid vehicle .
    A12-Iso5-2DC18
  • HY-143700
    18:0 DAP

    		Biochemical Assay Reagents Others
    18:0 DAP is a cationic or ionizable lipid with no unsaturated bonds in its hydrocarbon chain. The mRNA encapsulation efficiency of 18:0 DAP is 0%. 18:0 DAP cannot form functional lipid nanoparticles suitable for mRNA delivery .
    18:0 DAP
  • HY-156448
    80-O14B
    1 Publications Verification

    		 Liposome Cancer
    80-O14B is a cationic lipid-like compound. 80-O14B can be used in mRNA delivery studies .
    80-O14B
  • HY-151512
    A12-Iso5-4DC19

    		Liposome Inflammation/Immunology Cancer
    A12-Iso5-4DC19 is an ionizable cationic lipid. A12-Iso5-4DC19 can facilitate mRNA delivery and be used for the research of RNA vaccines .
    A12-Iso5-4DC19
  • HY-145798
    N1,N3,N5-Tris(4-dodecylhexadecyl)benzene-1,3,5-tricarboxamide

    		Liposome Others
    N1,N3,N5-Tris(4-dodecylhexadecyl)benzene-1,3,5-tricarboxamide is an analogue of TT3 (HY-148049). TT3 is an ionizable lipid-like materials for mRNA delivery .
    N1,N3,N5-Tris(4-dodecylhexadecyl)benzene-1,3,5-tricarboxamide
  • HY-171898
    Lipid I97

    		Liposome Inflammation/Immunology Cancer
    Lipid I97 is an ionizable lipid derived from vitamin B5 (pKa = 6.23). Lipid I97 can be used to generate lipid nanoparticles (LNPs) for mRNA delivery in vivo. Lipid I97 can be studied in research for enhancing mRNA transfection efficiency and long-term stability as well as formulation of mRNA vaccines .
    Lipid I97
  • HY-171896
    A28-C6B2

    		Liposome Inflammation/Immunology Cancer
    A28-C6B2 is an ionizable cationic lipid with a pKa of 6.43, and can be used to generate lipid nanoparticles (LNPs) for mRNA delivery in vivo. A28-C6B2 can be studied in research for enhancing the selective delivery of mRNA to the spleen, particularly to antigen-presenting cells .
    A28-C6B2
  • HY-164189
    m7(3'Ma-Cy3)Gppp(2'OMe)ApG ammonium

    		DNA/RNA Synthesis Others
    m7(3'Ma-Cy3)Gppp(2'OMe)ApG ammonium is a Cy3-labled cap analogue that can be used for mRNA synthesis. The efficiency of mRNA delivery can be determined by the detection of Cy3 by flow cytometry, which can be used to track mRNA in cells and in living animals and to screen delivery lipid ratios.
    m7(3'Ma-Cy3)Gppp(2'OMe)ApG ammonium
  • HY-153138
    FTT5 LLNs

    		Biochemical Assay Reagents Others
    FTT5 LLNs are functionalized lipid-like nanoparticles for in vivo mRNA delivery and base editing .
    FTT5 LLNs
  • HY-159735
    Lipid 23

    		Liposome Others
    Lipid 23 is an ionizable cationic amino lipid that can be used to generate lipid nanoparticles (LNP). Lipid 23 can be used for mRNA delivery .
    Lipid 23
  • HY-168776
    (S)-C12-200

    		Biochemical Assay Reagents Others
    (S)-C12-200 is the (S)-isomer of C12-200 (HY-145405), an ionizable cationic lipid and helper lipid. (S)-C12-200 can be utilized in the formation of lipid nanoparticles and mRNA delivery .
    (S)-C12-200
  • HY-151513
    Iso5-2DC18

    		Others Cancer
    Iso5-2DC18 is a lipid that can be used for the synthesis of amine containing lipids. These amine containing lipids can be used for mRNA delivery, activate the stimulator of interferon genes (STING) pathway, and exhibit anti-tumor immunity .
    Iso5-2DC18
  • HY-177344
    IAJD-97

    		Biochemical Assay Reagents Cancer
    IAJD-97 is a single-component ionizable amphiphilic Janus dendrimer carrier targeting mRNA delivery, which self-assembles into dendrimersomes (DNPs) via pH-responsive mechanisms to efficiently encapsulate and protect mRNA, while facilitating cellular uptake and endosomal escape through ionizable amine groups. IAJD-97 is promising for research of cancers .
    IAJD-97
  • HY-171897
    E10i-494

    		Liposome Inflammation/Immunology Cancer
    E10i-494 is an ionizable cationic branched endosomal disruptor (BEND) lipid. E10i-494 can be used to generate lipid nanoparticles (LNPs) for mRNA delivery in vitro. E10i-494 can enhance transfection efficiency .
    E10i-494
  • HY-P11453
    R9H6

    		Biochemical Assay Reagents Cancer
    R9H6 is a peptide containing nine arginine peptides and six histidine peptides. The LP(R9H6)m nanocomplex containing R9H6 exhibits high efficiency in mRNA delivery. R9H6 can be used in the research of anaplastic thyroid cancer .
    R9H6
  • HY-164191
    m7(3'Ma-Peg5-FAM)Gppp(2'OMe)ApG ammonium

    		DNA/RNA Synthesis Others
    m7(3'Ma-Peg5-FAM)Gppp(2'OMe)ApG ammonium is a FAM-labled cap analogue that can be used for mRNA synthesis. The efficiency of mRNA delivery can be determined by the detection of FAM by flow cytometry, which can be used to track mRNA in cells and in living animals and to screen delivery lipid ratios.
    m7(3'Ma-Peg5-FAM)Gppp(2'OMe)ApG ammonium
  • HY-172329
    Q1-ALC-0315 iodide

    		Liposome Others
    Q1-ALC-0315 iodide is a cationic quaternary ammonium lipid derivative of the ionizable cationic lipid ALC-0315 (HY-138170). Q1-ALC-0315-based LNPs can be used for lung-targeted mRNA delivery, which demonstrates high-performing firefly luciferase protein expression in the lungs .
    Q1-ALC-0315 iodide
  • HY-164188
    m7(3'Ma-Cy5)Gppp(2'OMe)ApG triammonium

    		DNA/RNA Synthesis Others
    m7(3'Ma-Cy5)Gppp(2'OMe)ApG ammonium is a Cy5-labled cap analogue that can be used for mRNA synthesis. The efficiency of mRNA delivery can be determined by the detection of Cy5 by flow cytometry, which can be used to track mRNA in cells and in living animals and to screen delivery lipid ratios.
    m7(3'Ma-Cy5)Gppp(2'OMe)ApG triammonium
  • HY-164187
    m7(3'Ma-Cy7)Gppp(2'OMe)ApG ammonium

    		DNA/RNA Synthesis Others
    m7(3'Ma-Cy7)Gppp(2'OMe)ApG ammonium is a Cy7-labled cap analogue that can be used for mRNA synthesis. The efficiency of mRNA delivery can be determined by the detection of Cy7 by flow cytometry, which can be used to track mRNA in cells and in living animals and to screen delivery lipid ratios.
    m7(3'Ma-Cy7)Gppp(2'OMe)ApG ammonium
  • HY-169480
    Lipid C2

    		Liposome Infection Cancer
    Lipid C2 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNP) for mRNA delivery in vivo. LNPs containing Lipid C2 and encapsulating an mRNA reporter selectively accumulate in the liver and spleen but not the heart, lungs, or kidneys in mice. LNP containing Lipid C2 and encapsulating mRNA encoding the Epstein-Barr virus (EBV) protein latent membrane protein 2 (LMP-2), in combination with an anti-programmed cell death protein 1 (PD-1) antibody, decrease tumor volume and reverse T cell exhaustion, as well as increase the percentage of CD3 +CD8 + central and CD3 +CD8 + effector memory T cells and decrease the percentage of CD3 + T cells expressing Pd-1, in the spleen in a CT26 murine EBV-infected colon cancer model .
    Lipid C2
  • HY-W1130452
    Lipid C16-C

    		Liposome Cancer
    Lipid C16-C is an ionizable cationic lipid that can be used to prepare lipid nanoparticles (LNPs) for mRNA delivery. Lipid C16-C mediates ApoE-independent macropinocytosis-based mRNA delivery to macrophages, with endosomal acidification enabling endosomal escape and release of mRNA cargo into the cytosol .
    Lipid C16-C
  • HY-175049
    ALC-0315 N-oxide

    		Endogenous Metabolite Others
    ALC-0315 N-oxide is an impurity of ALC-0315 ( HY-138170). ALC-0315 is an ionisable aminolipid for mRNA delivery .
    ALC-0315 N-oxide
  • HY-W1130459
    (R)-C12-200

    		Liposome Cancer
    (R)-C12-200 is the (R)-isomer of C12-200 (HY-145405), an ionizable cationic lipid and helper lipid. (R)-C12-200 enables functional mRNA delivery to head and neck squamous cell carcinoma xenograft tumor cells in NU/J immunocompromised mice, with minimal off-target delivery to liver or spleen. (R)-C12-200 can be utilized in the formation of lipid nanoparticles and mRNA delivery .
    (R)-C12-200
  • HY-175409
    Lipid 35 hydrochloride

    		Liposome Cancer
    Lipid 35 hydrochloride is an ionizable lipid that can be used for the generation of lipid nanoparticles (LNPs). Lipid 35 hydrochloride can be used for lung-specific mRNA delivery for metastatic lung tumors research .
    Lipid 35 hydrochloride
  • HY-W1130458
    503O8,12

    		Liposome Inflammation/Immunology
    503O8,12 is an ionizable cationic lipidoid that enables mRNA delivery to the spleen and lungs in mice when formulated into lipid nanoparticles with neutral helper lipid DOPE[1].
    503O8,12
  • HY-171784
    Lipid PPz-2R1

    		Liposome Cancer
    Lipid PPz-2R1 is a lung-targeted lipid. Lipid PPz-2R1 is formulated into lipid nanoparticles (LNPs) for mRNA delivery. Lipid PPz-2R1 can be used for in situ lung cancer research .
    Lipid PPz-2R1
  • HY-185284
    MeDZ lipid

    		Liposome Others
    MeDZ lipid is a zwitterion-type ionizable endosomal membrane destabilizer and anti-inflammatory agent that promotes endosomal escape. When incorporated into LNP formulations, MeDZ lipid enhances mRNA expression in lymph node antigen-presenting cells and promotes cytotoxic T cell activation. MeDZ lipid is compatible with existing targeted nanoparticle formulations to improve mRNA delivery efficiency .
    MeDZ lipid
  • HY-169478
    Lipid N2-3L

    		Liposome Cancer
    Lipid N2-3L is an ionizable cationic lipid (pKa = 8.99) that can be used to generate supramolecular lipid nanoparticles (SMLNPs) for mRNA delivery. Lipid nanoparticles formed by encapsulating a luciferase reporter gene with Lipid N2-3L were detected to accumulate in the lymph nodes of mice, indicating that they can effectively enter the mouse immune system. Lipid nanoparticles formed by encapsulating ovalbumin mRNA and the TLR7/8 agonist Resiquimod (HY-13740) with Lipid N2-3L were able to reduce tumor volume and increase survival in the MC-38-OVA mouse colon cancer model. Lipid N2-3L can be used in the research of drug delivery for cancer-related therapies .
    Lipid N2-3L

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